dc.contributor.author |
Augustine, Robin
|
|
dc.contributor.author |
Saha, Abhijit Saha
|
|
dc.contributor.author |
Jayachandran, V.P.
|
|
dc.contributor.author |
Thomas, Sabu
|
|
dc.contributor.author |
Kalarikkal, Nandakumar
|
|
dc.date.accessioned |
2015-03-27T06:16:24Z |
|
dc.date.available |
2015-03-27T06:16:24Z |
|
dc.date.issued |
2015 |
|
dc.description.abstract |
Electrospun membranes of polycaprolactone are widely used for biomedical
applications like wound dressings and tissue engineering scaffolds. It is important to sterilize
this material using the most accepted method, the gamma irradiation. In this study, we have
evaluated the sterilizability of electrospun polycaprolactone membranes with gamma
radiation of varying doses. The irradiated materials were assessed for the changes in
morphology, crystallinity, surface degradation, hydrophilicity, mechanical property, sterility
and the cell proliferation. Our results demonstrate that electrospun polycaprolactone can be
effectively sterilized by gamma irradiation, however a higher dose of radiation affect the materials properties. The irradiated membranes showed improved hydrophilicity and
fibroblast cell proliferation. |
en_ZA |
dc.description.embargo |
2016-01-31 |
en_ZA |
dc.description.librarian |
hb2015 |
en_ZA |
dc.description.sponsorship |
Department of Biotechnology (DBT), Government of India,
New Delhi.MSUB IPLSARE program. |
en_ZA |
dc.description.uri |
http://www.tandfonline.com/loi/gpom20 |
en_ZA |
dc.identifier.citation |
Robin Augustine, Abhijit Saha, V.P. Jayachandran, Sabu Thomas & Nandakumar Kalarikkal (2015) Dose- Dependent Effects of Gamma Irradiation on the Materials Properties and Cell Proliferation of Electrospun Polycaprolactone Tissue Engineering Scaffolds, International Journal of Polymeric Materials and Polymeric Biomaterials, 64:10, 526-533, DOI:10.1080/00914037.2014.977900. |
en_ZA |
dc.identifier.issn |
0091-4037 (print) |
|
dc.identifier.issn |
1563-535X (online) |
|
dc.identifier.other |
10.1080/00914037.2014.977900 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/44190 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Taylor and Francis |
en_ZA |
dc.rights |
© 2015 Taylor & Francis Group, LLC. This is an electronic version of an article published in International Journal of Polymeric Materials and Polymeric Biomaterials, vol.64, no.10, pp. 526-533, 2015. doi :10.1080/00914037.2014.977900. International Journal of Polymeric Materials and Polymeric Biomaterials is available online at : http://www.tandfonline.com/loi/gpom20. |
en_ZA |
dc.subject |
Cell proliferation |
en_ZA |
dc.subject |
Electrospinning |
en_ZA |
dc.subject |
Gamma radiation |
en_ZA |
dc.subject |
Polycaprolactone |
en_ZA |
dc.subject |
Sterilization |
en_ZA |
dc.title |
Dose-dependent effects of gamma irradiation on the materials properties and cell proliferation of electrospun polycaprolactone tissue engineering scaffolds |
en_ZA |
dc.type |
Postprint Article |
en_ZA |