Dose-dependent effects of gamma irradiation on the materials properties and cell proliferation of electrospun polycaprolactone tissue engineering scaffolds
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Date
Authors
Augustine, Robin
Saha, Abhijit Saha
Jayachandran, V.P.
Thomas, Sabu
Kalarikkal, Nandakumar
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor and Francis
Abstract
Electrospun membranes of polycaprolactone are widely used for biomedical
applications like wound dressings and tissue engineering scaffolds. It is important to sterilize
this material using the most accepted method, the gamma irradiation. In this study, we have
evaluated the sterilizability of electrospun polycaprolactone membranes with gamma
radiation of varying doses. The irradiated materials were assessed for the changes in
morphology, crystallinity, surface degradation, hydrophilicity, mechanical property, sterility
and the cell proliferation. Our results demonstrate that electrospun polycaprolactone can be
effectively sterilized by gamma irradiation, however a higher dose of radiation affect the materials properties. The irradiated membranes showed improved hydrophilicity and
fibroblast cell proliferation.
Description
Keywords
Cell proliferation, Electrospinning, Gamma radiation, Polycaprolactone, Sterilization
Sustainable Development Goals
Citation
Robin Augustine, Abhijit Saha, V.P. Jayachandran, Sabu Thomas & Nandakumar Kalarikkal (2015) Dose- Dependent Effects of Gamma Irradiation on the Materials Properties and Cell Proliferation of Electrospun Polycaprolactone Tissue Engineering Scaffolds, International Journal of Polymeric Materials and Polymeric Biomaterials, 64:10, 526-533, DOI:10.1080/00914037.2014.977900.