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dc.contributor.author | Peterlongo, Paolo![]() |
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dc.contributor.author | Chang-Claude, Jenny![]() |
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dc.contributor.author | Moysich, K.B.![]() |
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dc.contributor.author | Rudolph, A.![]() |
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dc.contributor.author | Schmutzler, Rita Katharina![]() |
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dc.contributor.author | Simard, Jacques![]() |
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dc.contributor.author | Soucy, Penny![]() |
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dc.contributor.author | Eeles, Rosalind A.![]() |
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dc.contributor.author | Easton, Douglas F.![]() |
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dc.contributor.author | Hamann, Ute![]() |
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dc.contributor.author | Wilkening, S.![]() |
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dc.contributor.author | Chen, B.![]() |
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dc.contributor.author | Rookus, Matti A.![]() |
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dc.contributor.author | Schmidt, Marjanka K.![]() |
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dc.contributor.author | Van Der Baan, F.H.![]() |
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dc.contributor.author | Spurdle, Amanda B.![]() |
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dc.contributor.author | Walker, L.C.![]() |
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dc.contributor.author | Lose, F.![]() |
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dc.contributor.author | Maia, A-T.![]() |
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dc.contributor.author | Montagna, Marco![]() |
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dc.contributor.author | Matricardi, L.![]() |
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dc.contributor.author | Lubinski, Jan![]() |
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dc.contributor.author | Jakubowska, Anna![]() |
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dc.contributor.author | Garcia, E.B.G.![]() |
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dc.contributor.author | Olopade, Olufunmilayo I.![]() |
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dc.contributor.author | Nussbaum, R.L.![]() |
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dc.contributor.author | Nathanson, Katherine L.![]() |
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dc.contributor.author | Domchek, Susan M.![]() |
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dc.contributor.author | Rebbeck, Timothy R.![]() |
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dc.contributor.author | Arun, Banu K.![]() |
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dc.contributor.author | Karlan, Beth Y.![]() |
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dc.contributor.author | Orsulic, Sandra![]() |
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dc.contributor.author | Lester, Jenny![]() |
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dc.contributor.author | Chung, Wendy K.![]() |
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dc.contributor.author | Miron, Alexander![]() |
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dc.contributor.author | Southey, Melissa C.![]() |
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dc.contributor.author | Goldgar, David E.![]() |
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dc.contributor.author | Buys, Saundra S.![]() |
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dc.contributor.author | Janavicius, Ramunas![]() |
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dc.contributor.author | Jansen van Rensburg, Elizabeth![]() |
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dc.contributor.author | Ding, Yuan Chun![]() |
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dc.contributor.author | Neuhausen, Susan L.![]() |
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dc.contributor.author | Hansen, Thomas V.O.![]() |
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dc.contributor.author | Gerdes, Anne-Marie![]() |
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dc.contributor.author | Ejlertsen, Bent![]() |
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dc.contributor.author | Jønson, L.![]() |
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dc.contributor.author | Osorio, Ana![]() |
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dc.contributor.author | Martínez-Bouzas, C.![]() |
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dc.contributor.author | Benitez, Javier![]() |
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dc.contributor.author | Conway, E.E.![]() |
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dc.contributor.author | Blazer, K.R.![]() |
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dc.contributor.author | Weitzel, Jeffrey N.![]() |
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dc.contributor.author | Manoukian, Siranoush![]() |
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dc.contributor.author | Peissel, Bernard![]() |
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dc.contributor.author | Zaffaroni, D.![]() |
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dc.contributor.author | Scuvera, G.![]() |
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dc.contributor.author | Barile, Monica![]() |
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dc.contributor.author | Ficarazzi, F.![]() |
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dc.contributor.author | Mariette, F.![]() |
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dc.contributor.author | Fortuzzi, S.![]() |
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dc.contributor.author | Viel, Alessandra![]() |
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dc.contributor.author | Gianotti, Giacomo![]() |
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dc.contributor.author | Papi, Laura![]() |
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dc.contributor.author | Martayan, A.![]() |
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dc.contributor.author | Tibiletti, Maria Grazia![]() |
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dc.contributor.author | Radice, Paolo![]() |
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dc.contributor.author | Fostira, Florentia![]() |
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dc.contributor.author | Garber, Judy![]() |
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dc.contributor.author | Donaldson, Alan![]() |
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dc.contributor.author | Brewer, Carole![]() |
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dc.contributor.author | Foo, Claire![]() |
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dc.contributor.author | Evans, D.G.R.![]() |
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dc.contributor.author | Frost, Debra![]() |
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dc.contributor.author | Eccles, Diana M.![]() |
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dc.contributor.author | Brady, A.![]() |
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dc.contributor.author | Cook, Jackie![]() |
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dc.contributor.author | Tischkowitz, Marc![]() |
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dc.contributor.author | Adlard, Julian![]() |
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dc.contributor.author | Barwell, J.![]() |
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dc.contributor.author | Walker, L.![]() |
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dc.contributor.author | Izatt, Louise![]() |
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dc.contributor.author | Side, Lucy E.![]() |
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dc.contributor.author | Kennedy, M.J.![]() |
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dc.contributor.author | Rogers, Mark T.![]() |
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dc.contributor.author | Porteous, Mary E.![]() |
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dc.contributor.author | Morrison, Patrick J.![]() |
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dc.contributor.author | Platte, Radka![]() |
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dc.contributor.author | Davidson, Richard S.![]() |
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dc.contributor.author | Hodgson, Shirley V.![]() |
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dc.contributor.author | Ellis, Steve![]() |
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dc.contributor.author | Cole, T.![]() |
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dc.contributor.author | Godwin, Andrew K.![]() |
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dc.contributor.author | Claes, Kathleen![]() |
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dc.contributor.author | Van Maerken, T.![]() |
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dc.contributor.author | Meindl, Alfons![]() |
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dc.contributor.author | Gehrig, Andrea![]() |
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dc.contributor.author | Sutter, Christian![]() |
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dc.contributor.author | Engel, Christoph![]() |
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dc.contributor.author | Niederacher, Dieter![]() |
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dc.contributor.author | Steinemann, Doris![]() |
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dc.contributor.author | Plendl, Hansjoerg![]() |
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dc.contributor.author | Kast, Karin![]() |
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dc.contributor.author | Rhiem, Kerstin![]() |
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dc.contributor.author | Ditsch, Nina![]() |
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dc.contributor.author | Arnold, Norbert![]() |
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dc.contributor.author | Varon-Mateeva, Raymonda![]() |
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dc.contributor.author | Wappenschmidt, Barbara![]() |
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dc.contributor.author | Wang-Gohrke, S.![]() |
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dc.contributor.author | Bressac-De Paillerets, B.![]() |
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dc.contributor.author | Buecher, B.![]() |
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dc.contributor.author | Delnatte, Capucine![]() |
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dc.contributor.author | Houdayer, Claude![]() |
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dc.contributor.author | Stoppa-Lyonnet, Dominique![]() |
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dc.contributor.author | Damiola, Francesca![]() |
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dc.contributor.author | Coupier, Isabelle![]() |
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dc.contributor.author | Barjhoux, Laure![]() |
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dc.contributor.author | Venat-Bouvet, Laurence![]() |
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dc.contributor.author | Golmard, Lisa![]() |
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dc.contributor.author | Boutry-Kryza, N.![]() |
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dc.contributor.author | Sinilnikova, Olga M.![]() |
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dc.contributor.author | Caron, O.![]() |
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dc.contributor.author | Pujol, Pascal![]() |
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dc.contributor.author | Mazoyer, Sylvie![]() |
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dc.contributor.author | Belotti, Muriel![]() |
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dc.contributor.author | Piedmonte, Marion![]() |
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dc.contributor.author | Friedlander, Michael L.![]() |
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dc.contributor.author | Rodriguez, Gustavo C.![]() |
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dc.contributor.author | Copeland, L.J.![]() |
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dc.contributor.author | De la Hoya, Miguel![]() |
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dc.contributor.author | Segura, P.P.![]() |
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dc.contributor.author | Nevanlinna, Heli![]() |
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dc.contributor.author | Aittomäki, K.![]() |
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dc.contributor.author | Van Os, Theo A.M.![]() |
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dc.contributor.author | Meijers-Heijboer, Hanne E.J.![]() |
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dc.contributor.author | Van der Hout, Annemarie H.![]() |
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dc.contributor.author | Vreeswijk, Maaike P.G.![]() |
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dc.contributor.author | Hoogerbrugge, N.![]() |
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dc.contributor.author | Ausems, Margreet G.E.M.![]() |
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dc.contributor.author | Van Doorn, H.C.![]() |
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dc.contributor.author | Collee, J.M.![]() |
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dc.contributor.author | Olah, Edith![]() |
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dc.contributor.author | Diez, Orland![]() |
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dc.contributor.author | Blanco, Ignacio![]() |
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dc.contributor.author | Lazaro, Conxi![]() |
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dc.contributor.author | Brunet, Joan![]() |
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dc.contributor.author | Feliubadalo, Lidia![]() |
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dc.contributor.author | Cybulski, C.![]() |
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dc.contributor.author | Gronwald, Jacek![]() |
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dc.contributor.author | Durda, Katarzyna![]() |
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dc.contributor.author | Jaworska-Bieniek, K.![]() |
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dc.contributor.author | Sukiennicki, G.![]() |
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dc.contributor.author | Arason, Adalgeir![]() |
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dc.contributor.author | Chiquette, J.![]() |
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dc.contributor.author | Teixeira, M.R.![]() |
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dc.contributor.author | Olswold, Curtis![]() |
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dc.contributor.author | Couch, Fergus J.![]() |
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dc.contributor.author | Lindor, Noralane M.![]() |
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dc.contributor.author | Wang, Xianshu![]() |
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dc.contributor.author | Szabo, Csilla I.![]() |
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dc.contributor.author | Offit, Kenneth![]() |
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dc.contributor.author | Corines, Marina J.![]() |
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dc.contributor.author | Jacobs, L. (Liesel)![]() |
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dc.contributor.author | Robson, Mark E.![]() |
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dc.contributor.author | Zhang, L.![]() |
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dc.contributor.author | Joseph, V.![]() |
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dc.contributor.author | Berger, Andreas![]() |
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dc.contributor.author | Singer, Christian F.![]() |
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dc.contributor.author | Rappaport, Christine![]() |
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dc.contributor.author | Kaulich, D.G.![]() |
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dc.contributor.author | Pfeiler, Georg![]() |
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dc.contributor.author | Tea, Muy-Kheng M.![]() |
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dc.contributor.author | Phelan, Catherine M.![]() |
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dc.contributor.author | Greene, Mark H.![]() |
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dc.contributor.author | Mai, Phuong L.![]() |
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dc.contributor.author | Rennert, Gad![]() |
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dc.contributor.author | Mulligan, Anna Marie![]() |
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dc.contributor.author | Glendon, Gord![]() |
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dc.contributor.author | Tchatchou, S.![]() |
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dc.contributor.author | Andrulis, Irene L.![]() |
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dc.contributor.author | Toland, Amanda Ewart![]() |
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dc.contributor.author | Bojesen, Anders![]() |
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dc.contributor.author | Pedersen, Inge Sokilde![]() |
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dc.contributor.author | Thomassen, Mads![]() |
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dc.contributor.author | Jensen, Uffe Birk![]() |
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dc.contributor.author | Laitman, Yael![]() |
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dc.contributor.author | Rantala, J.![]() |
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dc.contributor.author | Von Wachenfeldt, A.![]() |
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dc.contributor.author | Ehrencrona, Hans![]() |
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dc.contributor.author | Askmalm, M.S.![]() |
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dc.contributor.author | Borg, Ake![]() |
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dc.contributor.author | Kuchenbaecker, Karoline B.![]() |
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dc.contributor.author | McGuffog, Lesley![]() |
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dc.contributor.author | Barrowdale, Daniel![]() |
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dc.contributor.author | Healey, Sue![]() |
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dc.contributor.author | Lee, Adam![]() |
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dc.contributor.author | Pharoah, Paul D.P.![]() |
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dc.contributor.author | Chenevix-Trench, Georgia![]() |
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dc.contributor.author | Antoniou, Antonis C.![]() |
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dc.contributor.author | Friedman, Eitan![]() |
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dc.contributor.upauthor | Dorfling, Cecilia Maria | |
dc.date.accessioned | 2015-02-04T11:03:54Z | |
dc.date.available | 2015-02-04T11:03:54Z | |
dc.date.issued | 2015-01 | |
dc.description.abstract | BACKGROUND: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes. METHODS: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach. RESULTS: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments. CONCLUSION: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers. | en_ZA |
dc.description.embargo | 2016-01-31 | en_ZA |
dc.description.librarian | hb2015 | en_ZA |
dc.description.uri | http://cebp.aacrjournals.org | en_ZA |
dc.identifier.citation | Peterlongo, P, Chang-Claude, J, Moysich, K.B et al. 2015, 'Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no.1, pp. 308-316. | en_ZA |
dc.identifier.issn | 1055-9965 (print) | |
dc.identifier.issn | 1538-7755 (online) | |
dc.identifier.other | 10.1158/1055-9965 | |
dc.identifier.uri | http://hdl.handle.net/2263/43541 | |
dc.language.iso | en | en_ZA |
dc.publisher | American Association for Cancer Research | en_ZA |
dc.rights | © 2014 American Association for Cancer Research | en_ZA |
dc.subject | Candidate genetic modifiers | en_ZA |
dc.subject | Breast and ovarian cancer | en_ZA |
dc.subject | Risk | en_ZA |
dc.subject | BRCA1 | en_ZA |
dc.subject | BRCA2 | en_ZA |
dc.subject | Mutation carriers | en_ZA |
dc.title | Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers | en_ZA |
dc.type | Postprint Article | en_ZA |