Biotransformation : can we apply this to allergy and immunology?

Show simple item record Els, Carla 2014-08-22T06:36:38Z 2014-08-22T06:36:38Z 2014-03
dc.description.abstract During medical training all doctors are taught the importance of the cytochrome P450 (CYP) system and the detoxification functions of the liver. An important challenge for pharmaceutical companies is launching new pharmaceutical entities that have an acceptable safety profile and this usually entails finding molecules with a limited effect on the CYP system. Biotransformation seems to be a novel concept in allergy and immunology but ironically it has been used extensively in the medical field over many decades. This article is aimed at providing a differential diagnosis to those patients that do not quite fit the allergic picture/profile, using the concept of biotransformation to analyse them and ideally find a new solution to their disease profile. Examples of these extraordinary patients include those with numerous drug reactions but with no common ‘allergic’ trigger, recurring upper airway infections or chronic otitis media and common variable immunodeficiency, difficult to control asthmatics with concomitant inflammatory diseases like ulcerative colitis and the ‘allergic’ rhinitic with no obvious causative allergen. en_US
dc.description.librarian am2014 en_US
dc.description.uri en_US
dc.identifier.citation Els, C 2014, 'Biotransformation : can we apply this to allergy and immunology?', Current Allergy & Clinical Immunology, vol. 27, no. 1, pp. 32-35. en_US
dc.identifier.issn 1609-3607
dc.language.iso en en_US
dc.publisher Allergy Society of South Africa en_US
dc.rights Allergy Society of South Africa en_US
dc.subject CYP system en_US
dc.subject Biotransformation en_US
dc.subject Allergy and immunology en_US
dc.subject Cytochrome P450 (CYP) en_US
dc.subject Upper airway infections en_US
dc.subject Chronic otitis media en_US
dc.subject Variable immunodeficiency en_US
dc.subject Asthmatics en_US
dc.subject Concomitant inflammatory diseases en_US
dc.title Biotransformation : can we apply this to allergy and immunology? en_US
dc.type Article en_US

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