Biotransformation : can we apply this to allergy and immunology?

dc.contributor.authorEls, Carla
dc.date.accessioned2014-08-22T06:36:38Z
dc.date.available2014-08-22T06:36:38Z
dc.date.issued2014-03
dc.description.abstractDuring medical training all doctors are taught the importance of the cytochrome P450 (CYP) system and the detoxification functions of the liver. An important challenge for pharmaceutical companies is launching new pharmaceutical entities that have an acceptable safety profile and this usually entails finding molecules with a limited effect on the CYP system. Biotransformation seems to be a novel concept in allergy and immunology but ironically it has been used extensively in the medical field over many decades. This article is aimed at providing a differential diagnosis to those patients that do not quite fit the allergic picture/profile, using the concept of biotransformation to analyse them and ideally find a new solution to their disease profile. Examples of these extraordinary patients include those with numerous drug reactions but with no common ‘allergic’ trigger, recurring upper airway infections or chronic otitis media and common variable immunodeficiency, difficult to control asthmatics with concomitant inflammatory diseases like ulcerative colitis and the ‘allergic’ rhinitic with no obvious causative allergen.en_US
dc.description.librarianam2014en_US
dc.description.urihttp://www.allergysa.org/journal.htmen_US
dc.identifier.citationEls, C 2014, 'Biotransformation : can we apply this to allergy and immunology?', Current Allergy & Clinical Immunology, vol. 27, no. 1, pp. 32-35.en_US
dc.identifier.issn1609-3607
dc.identifier.urihttp://hdl.handle.net/2263/41534
dc.language.isoenen_US
dc.publisherAllergy Society of South Africaen_US
dc.rightsAllergy Society of South Africaen_US
dc.subjectCYP systemen_US
dc.subjectBiotransformationen_US
dc.subjectAllergy and immunologyen_US
dc.subjectCytochrome P450 (CYP)en_US
dc.subjectUpper airway infectionsen_US
dc.subjectChronic otitis mediaen_US
dc.subjectVariable immunodeficiencyen_US
dc.subjectAsthmaticsen_US
dc.subjectConcomitant inflammatory diseasesen_US
dc.titleBiotransformation : can we apply this to allergy and immunology?en_US
dc.typeArticleen_US

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