Cardiomyopathy of ruminants induced by the litter of poultry fed on rations containing the ionophore antibiotic, maduramicin. 1. Epidemiology, clinical signs and clinical pathology

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dc.contributor.author Fourie, Nicole
dc.contributor.author Bastianello, Stella S.
dc.contributor.author Nel, P.W.
dc.contributor.author Kellerman, T. Stephanus
dc.contributor.editor Verwoerd, Daniel Wynand
dc.contributor.upauthor Prozesky, Leon
dc.date.accessioned 2014-08-19T06:03:56Z
dc.date.available 2014-08-19T06:03:56Z
dc.date.created 2013
dc.date.issued 1991
dc.description The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. en
dc.description.abstract The epidemiological, clinical and clinical pathological findings in 20 cattle and 4 sheep from 15 outbreaks of poultry litter toxicity in South Africa over the past 6 years are documented. In 6 outbreaks, the litter emanated from batteries where maduramicin had been incorporated into rations of broilers. According to circumstantial evidence the litter involved in the 9 other outbreaks was also derived from broilers which had been fed on rations containing an ionophore. The litter was fed ad libitum to the affected stock or constituted 30-80% by volume of their rations. The principal sign manifested was sudden mortality of up to 70% of the herd or flock, usually within 20-40 days of commencement of feeding of poultry litter. A few cattle developed signs of congestive heart failure, and stiffness was commonly seen in sheep. In a dosing trial with poultry litter involving 1 steer and 6 sheep, the steer and a sheep died suddenly and a second sheep was destroyed in extremis. Tachycardia and/or cardiac arrythmia were recorded in 5 sheep, and the activity of aspartate transaminase (AST) and/or lactate dehydrogenase (LD) in the sera of 4 was elevated. Since the cardiac lesions in field cases were similar to those of ionophore poisoning and broiler rations containing maduramicin was a common factor in several outbreaks, toxic litter from some of these outbreaks were tested for the presence of this compound. Analysis by high performance liquid chromatography of litter from 2 specimens of outbreaks revealed that they contained 2,5ppm and 6,1ppm maduramicin. Sheep in a trial fed rations incorporating c 2,5ppm and 5ppm maduramicin, developed clinical signs and lesions consistent with those of the field cases. en
dc.description.librarian mn2014
dc.identifier.citation Fourie, N, Bastianello, SS, Prozesky, L, Nel, PW & Kellerman, TS 1991, 'Cardiomyopathy of ruminants induced by the litter of poultry fed on rations containing the ionophore antibiotic, maduramicin. 1. Epidemiology, clinical signs and clinical pathology’, Onderstepoort Journal of Veterinary Research, vol. 58, no. 4, pp. 291-296. en
dc.identifier.issn 0330-2465
dc.identifier.uri http://hdl.handle.net/2263/41420
dc.language.iso en en
dc.publisher Published by the Agricultural Research Council, Onderstepoort Veterinary Institute. en
dc.rights ©South Africa. Dept. of Agricultural Technical Services. ©University of Pretoria. Dept. of Library Services (digital). en
dc.subject Veterinary medicine en
dc.subject.lcsh Veterinary medicine -- South Africa
dc.title Cardiomyopathy of ruminants induced by the litter of poultry fed on rations containing the ionophore antibiotic, maduramicin. 1. Epidemiology, clinical signs and clinical pathology en
dc.type Article en


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