SAG-2 oral rabies vaccine

Show simple item record Schumacher, C.L. Coulon, Patrice Lafay, F. Benejean, J. Aubert, M.F.A. Barrat, J. Aubert, A. Flamand, Anne Rabies in Southern and Eastern Africa. Workshop. (1993, Pretoria, South Africa)
dc.contributor.editor Verwoerd, Daniel Wynand 2014-08-15T08:18:48Z 2014-08-15T08:18:48Z 2013 1993
dc.description The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. en
dc.description.abstract The live modified rabies virus vaccine strain SAG-2 was selected from SAD Berne in a two step process employing anti-rabies glycoprotein monoclonal antibodies. The first two nucleotides coding for the amino acid in position 333 of the rabies glycoprotein are mutated. Arginine at position 333, which is associated with rabies pathogenicity, was substituted first by lysine and then by glutamic acid. The two nucleotide differences at position 333 in SAG-2 to any of six possible arginine triplets translated into excellent genetic stability and apathogenicity for adult mice, foxes, cats and dogs. The vaccination of foxes and dogs by the oral route provided protection against a lethal challenge with rabies virus. en
dc.description.librarian mn2014
dc.identifier.citation Schumacher, CL, Coulon, P, Lafay, F, Benejean, J, Aubert, MFA, Barrat, J, Aubert, A & Flamand, A 1993, 'SAG-2 oral rabies vaccine’, Onderstepoort Journal of Veterinary Research, vol. 60, no. 4, pp. 459-462. en
dc.identifier.issn 0330-2465
dc.language.iso en en
dc.publisher Published by the Agricultural Research Council, Onderstepoort Veterinary Institute en
dc.rights © ARC-Onderstepoort (original). © University of Pretoria. Dept of Library Services (digital). en
dc.subject Veterinary medicine en
dc.subject Rabies in southern and eastern Africa. Proceedings of a workshop held at the Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa, 3-5 May 1993 en
dc.subject.lcsh Veterinary medicine -- South Africa
dc.subject.lcsh Rabies in animals en
dc.title SAG-2 oral rabies vaccine en
dc.type Article en

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