dc.contributor.author |
Swan, Gerry E.
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|
dc.contributor.author |
Du Preez, J.L.
|
|
dc.contributor.editor |
Verwoerd, Daniel Wynand |
|
dc.contributor.upauthor |
Gummow, Bruce
|
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dc.date.accessioned |
2014-01-21T09:15:16Z |
|
dc.date.available |
2014-01-21T09:15:16Z |
|
dc.date.created |
2013 |
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dc.date.issued |
1994 |
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dc.description |
The articles have been scanned in colour with a HP Scanjet 5590; 600dpi.
Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. |
en |
dc.description.abstract |
The bioequivalence of the diminazene formulation Veriben (Centaur) was determined in cattle (n=10) by means of a single-dose, randomized cross-over experiment. The results of nine statistical procedures commonly used for bioequivalence evaluation are discussed. Veriben was found to be equivalent to Berenil (Hoechst) with respect to the area under the plasma concentration versus time curve, but not in terms of the maximum plasma drug concentration and the time to maximum plasma drug concentration. Pharmacokinetic parameters were calculated in which bioequivalence data (n=10)
together with data from an additional four cattle were used. A two-compartment model best described
the pharmacokinetic behaviour of diminazene in cattle. Peak concentrations of diminazene (3,24 ± 0,16μg/ml) were reached 49,8 (± 7,6) min after intramuscular injection of 3,5 mg/kg drug, with absorption proceeding rapidly (t½α=1,93 ± 0,95h). Diminazene was slowly eliminated (t½β=222 h), resulting in a mean residence time of 13,27 d. The safe interval necessary between successive treatments of
diminazene or before live babesia vaccines should be administered, and a recommended pre-slaughter withdrawal period are also discussed. |
en |
dc.description.librarian |
mn2014 |
|
dc.description.sponsorship |
Milborrow Animal Health. |
en |
dc.identifier.citation |
Gummow, B, Swan, GE & Du Preez, JL 1994, 'A bioequivalence and pharmacokinetic evaluation of two commercial diminazene aceturate formulations administered intramuscularly to cattle’, Onderstepoort Journal of Veterinary Research, vol. 61, no. 4, pp. 317-326. |
en |
dc.identifier.issn |
0330-2465 |
|
dc.identifier.other |
7102127047 |
|
dc.identifier.other |
I-7222-2013 |
|
dc.identifier.other |
7003908833 |
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dc.identifier.other |
N-9314-2014 |
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dc.identifier.uri |
http://hdl.handle.net/2263/33049 |
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dc.language.iso |
en |
en |
dc.publisher |
Published by the Agricultural Research Council, Onderstepoort Veterinary Institute |
en |
dc.rights |
© ARC-Onderstepoort (original).
© University of Pretoria. Dept of Library Services (digital). |
en |
dc.subject |
Veterinary medicine |
en |
dc.subject.lcsh |
Veterinary medicine -- South Africa |
|
dc.title |
A bioequivalence and pharmacokinetic evaluation of two commercial diminazene aceturate formulations administered intramuscularly to cattle |
en |
dc.type |
Article |
en |