Browsing Pharmacology by Author "Lilley, Kathryn S."

Browsing Pharmacology by Author "Lilley, Kathryn S."

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  • A draft map of the mouse pluripotent stem cell spatial proteome 
    Christoforou, Andy; Mulvey, Claire M.; Breckels, Lisa M.; Geladaki, Aikaterini; Hurrell, Tracey; Hayward, Penelope C.; Naake, Thomas; Gatto, Laurent; Viner, Rosa; Arias, Alfonso Martinez; Lilley, Kathryn S. (Nature Publising Group, 2016-01)
    Knowledge of the subcellular distribution of proteins is vital for understanding cellular mechanisms. Capturing the subcellular proteome in a single experiment has proven challenging, with studies focusing on specific ...
  • Proteomic comparison of various hepatic cell cultures for preclinical safety pharmacology 
    Hurrell, Tracey; Segeritz, Charis-Patricia; Vallier, Ludovic; Lilley, Kathryn S.; Cromarty, Allan Duncan (Oxford University Press, 2018-07)
    Experimental drugs need to be screened for safety within time constraints. Hepatotoxicity is one concerning contributor to the failure of investigational new drugs and a major rationale for postmarketing withdrawal decisions. ...
  • Proteomic responses of HepG2 cell monolayers and 3D spheroids to selected hepatotoxins 
    Hurrell, Tracey; Lilley, Kathryn S.; Cromarty, Allan Duncan (Elsevier, 2019-01)
    Despite the importance of hepatotoxicity testing in the development of new potential pharmaceuticals, standardized methods for preclinical in vitro hepatotoxicity is complicated by the perceived adequacy of approach, ...
  • A proteomic time course through the differentiation of human induced pluripotent stem cells into hepatocyte-like cells 
    Hurrell, Tracey; Segeritz, Charis-Patricia; Vallier, Ludovic; Lilley, Kathryn S.; Cromarty, Allan Duncan (Nature Publishing Group, 2019-03-01)
    Numerous in vitro models endeavour to mimic the characteristics of primary human hepatocytes for applications in regenerative medicine and pharmaceutical science. Mature hepatocyte-like cells (HLCs) derived from human ...