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Browsing Pharmacology by Author "Cordier, Werner"
Now showing items 1-20 of 22
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Lepule, Keagile Hilda; Cordier, Werner; Steenkamp, Paul; Nell, Margo Judith; Steenkamp, Vanessa (Elsevier, 2019-11)Parkinson’s disease, characterised by loss of dopaminergic neurons in the substantia nigra of the brain, is attributed to oxidative stress and mitochondrial dysfunction. As no cure is available, and dopamine-replacement ...
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Yahaya, Ewura Seidu; Cordier, Werner; Steenkamp, Paul Anton; Steenkamp, Vanessa (Wiley, 2018-01)OBJECTIVES : Whole plants of Boerhavia diffusa L. are widely used medicine in Ghana and other tropical countries, for the treatment of wounds and other ailments. The aim of the study was to determine the ability of sequential ...
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Cordier, Werner; Gulumian, Mary; Cromarty, Allan Duncan; Steenkamp, Vanessa (BioMed Central, 2013-05-28)BACKGROUND: Oxidative stress has been implicated in the progression of various diseases, which may result in the depletion of endogenous antioxidants. Exogenous supplementation with antioxidants could result in ...
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Van der Westhuizen, Carl Johan; Van Greunen, D.G. (Divan); Cordier, Werner; Nell, Margo Judith; Steenkamp, Vanessa; Stander, Andre; Panayides, Jenny-Lee; Riley, Darren L. (ARKAT, 2020-04)β-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer’s disease, and transition-state isosteres such as hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors. A computational ...
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Cordier, Werner; Steenkamp, Vanessa (Elsevier, 2018-01)INTRODUCTION : Traditional remedies remain a prominent form of therapy in developing countries, such as South Africa. Boophone disticha, or the poison bulb, is used for the treatments of wounds. There is generally a lack ...
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Josiah, Andrea Jess; Pillai, Sreejarani Kesavan; Cordier, Werner; Nell, Margo Judith; Twilley, Danielle; Lall, Namrita; Ray, Suprakas Sinha (American Chemical Society, 2021-10-21)This study investigated a unique one-pot microwave- assisted green synthesis method of gold (Au) and silver (Ag) nanoparticles (NPs) using cannabidiol (CBD) as a capping and reducing agent. Furthermore, Au and Ag NPs ...
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Yahaya, Ewura Seidu; Cordier, Werner; Steenkamp, P.A.; Steenkamp, Vanessa (Elsevier, 2018-09)The inhibition of reactive oxygen species (ROS) and the migration of fibroblasts are key processes involved in wound healing. In this study, the ability of aqueous ethnomedicinal plant extracts prepared from Aspilia africana ...
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Cordier, Werner (University of Pretoria, 2013-01-07)Free radicals have been implicated in the progression of various diseases, such as cancers and cardiomyopathies. When the body is overburdened with free radicals and endogenous antioxidants become depleted, oxidative stress ...
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Cordier, Werner; Cromarty, Allan Duncan; Botha, Elsabie M.D.; Steenkamp, Vanessa (SAGE, 2012-03)The use of herbal preparations for staunching blood flow and reducing the risk of vascular thrombosis is common worldwide. In this study, aqueous and methanolic extracts of plants used to treat blood-associated complaints ...
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Cordier, Werner; Steenkamp, Paul; Steenkamp, Vanessa (Elsevier, 2020-03)Moringa oleifera Lam. has received much praise over its potential benefits to health and nutrition, however, not much literature is available to support claims of hepatic safety. The liver, as primary xenobiotic metaboliser, ...
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Cordier, Werner; Steenkamp, Vanessa (Routledge, 2012-04)CONTEXT: Herbal remedies are used to treat a large variety of diseases, including blood-related disorders. However, a number of herbal preparations have been reported to cause variations in clotting time, this is mainly ...
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Ndlovu, Gugulethu; Fouche, Gerda; Tselanyane, Malefa; Cordier, Werner; Steenkamp, Vanessa (BioMed Central, 2013-11-05)BACKGROUND: Aging is an inevitable process for all living organisms. During this process reactive oxygen species generation is increased which leads to the activation of hyaluronidase, collagenase and elastase, which can ...
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Cordier, Werner (University of Pretoria, 2016)Herbal remedies are an important and often-used commodity in developing countries, such as those in Africa. There is a long-standing belief that these medicinal preparations are more effective and safe than allopathic ...
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Cordier, Werner (Medpharm Publications, 2021-08)Hand hygiene practices have been bolstered during the COVID-19 pandemic to curb the spread of SARS-CoV-2. Unfortunately, such prevention strategies come with a risk of excessive physical damage to the skin and exposure ...
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Fobian, Seth-Frerich; Petzer, Melissa; Vetten, Melissa; Steenkamp, Vanessa; Gulumian, Mary; Cordier, Werner (Oxford University Press, 2022-09)OBJECTIVES : Nanomedicines represent theragnostic alternatives to traditional candidate drugs, with increased targeting and delivery potential due to their size and functional tailorability. Biological activity typically ...
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Josiah, Andrea Jess; Pillai, Sreejarani K.; Cordier, Werner; Nell, Margo Judith; Lall, Namrita; Twilley, Danielle; Ray, Suprakas Sinha (Wiley, 2024-02)Please read abstract in the article.
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Yahaya, Ewura Seidu; Cordier, Werner; Steenkamp, Paul A.; Steenkamp, Vanessa (Academic Association of Pharmacuetical Sciences from Antofagasta, 2020-02)CONTEXT : Erythrina senegalensis (ES) DC. is used traditionally in the management of various free radical-related diseases, including wound healing. AIMS : To evaluate sequentially prepared leaf extracts of ES for the ...
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Burger, Trevor; Mokoka, Tsholofelo; Fouche, Gerda; Steenkamp, Paul; Steenkamp, Vanessa; Cordier, Werner (BioMed Central, 2018-05-02)BACKGROUND : Solanum aculeastrum fruits are used by some cancer sufferers as a form of alternative treatment. Scientific literature is scarce concerning its anticancer activity, and thus the aim of the study was to assess ...
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Kakono, Tsungirirai V.; Mathye, Desmond; Brand, S.J. (Sarel); Cordier, Werner (AOSIS Open Journals, 2023-06-23)BACKGROUND : The extension of medicine prescription rights to other healthcare providers was proposed to reduce pharmacotherapeutic service delivery challenges in the South African healthcare sector. The scope of practice ...
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Cordier, Werner; Lubbe, J.C. (Irene) (Health and Medical Publishing Group, 2021-09)The COVID-19 pandemic placed educators in unique circumstances, not only due to their discipline- and student-specific considerations, but also their personal and professional milieu. Given a series of sudden ...
Now showing items 1-20 of 22