Browsing Pharmacology by Title

Browsing Pharmacology by Title

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  • Joint pain and ageing 
    Marais, Andre (Plus 50 Media (Pty) Ltd, 2016-06)
    To wake up every day with some kind of body pain or stiff muscles is a common occurrence as one grows older. This can be attributed to a variety of conditions; some are related to an increase in age, while others may have ...
  • Knowledge, attitude and practices of self-medication including antibiotics among health care professionals during the COVID-19 pandemic in Pakistan : findings and implications 
    Mustafa, Zia Ul; Iqbal, Shahid; Asif, Hafiz Rahil; Salman, Muhammad; Jabbar, Sehar; Mallhi, Tauqeer Hussain; Khan, Yusra Habib; Sono, Tiyani Milta; Schellack, Natalie; Meyer, Johanna C.; Godman, Brian (MDPI, 2023-02)
    Since the emergence of COVID-19, several different medicines including antimicrobials have been administered to patients to treat COVID-19. This is despite limited evidence of the effectiveness of many of these, fueled by ...
  • Limitations of the 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay when compared to three commonly used cell enumeration assays 
    Van Tonder, Alet; Joubert, Annie M.; Cromarty, Allan Duncan (BioMed Central, 2013-02-20)
    BACKGROUND : The tetrazolium-based MTT assay has long been regarded as the gold standard of cytotoxicity assays as it is highly sensitive and has been miniaturised for use as a high-throughput screening assay. However, ...
  • Local tolerability of two low-molecular-weight heparins, nadroparin and enoxaparin 
    Mathijs, Sophie; Van Tonder, J.J.; Dippenaar, Johannes Marthinus (Tinus) (MedPharm Publications, 2020-09)
    Subcutaneous administration of low-molecular-weight heparins is associated with localised injection site reactions such as acute pain, bruising, induration, and haematomas. Repeated exposure to such painful procedures may ...
  • Macromolecular antiproliferative agents featuring dicarboxylato-chelated platinum 
    Komane, L.L.; Mukaya, E.H.; Neuse, E.W.; Jansen van Rensburg, Connie E. (Springer, 2008)
    Cancerous diseases, together with cardiac afflictions, account for the predominant causes of death among the adult population of the Western world. The classical platinum drugs, with cisplatin as their parent, have established ...
  • Magnesium : effects on physical and mental performance 
    Outhoff, Kim (MedPharm Publications, 2016)
    Magnesium is a chemical element used by every organ in the body, especially the brain, skeletal muscles and the heart. It functions as a cofactor in approximately 600 enzyme systems that regulate many different biochemical ...
  • Malaria : know your enemy 
    Marais, Andre (Plus 50 Media (Pty) Ltd, 2019-04)
    The 25th April is World Malaria Day and in this article ANDRé MARAIS tells us more about this disease, its cause and its prevention. Malaria is a common and potentially life-threatening disease in tropical and subtropical ...
  • Malaria prevention in travelling children 
    Mathijs, Sophie (South African Academy of Family Practice/Primary Care, 2012)
    Preventing malaria in children is often neglected. Prevention is very important, as malaria is still a significant cause of childhood mortality. Parents must be aware that the same measures must be taken by children to ...
  • Management of acute upper respiratory tract infection : the role of early intervention 
    Wang, De Yun; Eccles, Ronald; Bell, John; Chua, Antonio Hao; Salvi, Sundeep; Schellack, Natalie; Marks, Paulette; Wong, Yong Chiat (Taylor and Francis, 2021)
    INTRODUCTION : Upper respiratory tract infection (URTI) is an illness caused by an acute infection by viruses or bacteria of the nose, sinuses, pharynx, and larynx. Most URTIs are short, mild, and self-limiting, but some ...
  • The management of worsening heart failure 
    Ker, James A.; Outhoff, Kim (Medpharm Publications, 2020-07)
    Heart failure is a heterogeneous progressive syndrome of symptoms and signs, a culmination of structural and/or functional abnormalities of the heart. There is an elevated intracardiac pressure or reduced cardiac output ...
  • The many possible causes of dizziness 
    Marais, Andre (Plus 50 Media (Pty) Ltd, 2018-08)
    Dizziness or vertigo is a common complaint, which affects 15% to 20% of adults every year. The incidence increases with age and 70% of individuals aged 65 years and above will probably consult their general practitioner ...
  • Mass spectrometric proteomic profiling of acute wound healing processes in the porcine model 
    Sheva, Kim Lisa (University of Pretoria, 2019)
    Wounds are a common occurrence and generally heal well within a short time depending on whether tissue needs to be replaced or not. Although there is an understanding of the physiological processes taking place during wound ...
  • A matter of urgency : a brief update on the aetiology and treatment of uncomplicated urinary tract infections 
    Brand, S.J. (Sarel) (Medpharm Publications, 2020)
    Health professionals in general practice regularly encounter women suffering from symptoms associated with urinary tract infections (UTIs). Uncomplicated UTIs have a high incidence and are commonly associated with recurrence. ...
  • Mechanisms facilitating the uptake of carboxyl-polythene glycol-functionalized gold nanoparticles into multicellular spheroids 
    Fobian, Seth-Frerich; Petzer, Melissa; Vetten, Melissa; Steenkamp, Vanessa; Gulumian, Mary; Cordier, Werner (Oxford University Press, 2022-09)
    OBJECTIVES : Nanomedicines represent theragnostic alternatives to traditional candidate drugs, with increased targeting and delivery potential due to their size and functional tailorability. Biological activity typically ...
  • Mechanisms of potential novel antimalarials and proteomics of Plasmodium falciparum resistance 
    Steyn, Denise (University of Pretoria, 2016)
    Introduction: Plasmodium falciparum is the dominant cause of severe malaria in humans, with the highest number of global deaths occurring in Africa and Southeast Asia. Even though artemisinin-derivative combination therapies ...
  • A mechanistic study of organochlorine hepatotoxicity 
    Schroeder, Ilka Elizma (University of Pretoria, 2011)
    Pentachlorophenol, (PCP) is an organochlorine compound which was first developed in the 1930’s. PCP is said to be the most toxic of the chlorophenols and is classified as a hazardous substance and a probable human carcinogen. ...
  • The medical management of glaucoma 
    Marais, Andre; Osuch, Elzbieta (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor and Francis Group, 2017)
    Glaucoma is one of the leading causes of blindness worldwide. The main characteristic features include optic disc cupping, visual field loss, and in most instances a raised intraocular pressure. Primary open angle glaucoma ...
  • Medication : your heart's worst enemy? 
    Marais, Andre (Plus 50 Media (Pty) Ltd., 2016-08)
    Current life expectancy, as determined by the World Health Organization in 2015, estimates males to live for about 71 years and females for approximately 73 years. On average, South Africa has lower life expectancy, with ...
  • Medicinal applications and toxicological activities of Aloe products 
    Steenkamp, Vanessa; Stewart, M.J. (Taylor & Francis, 2007)
    Aloe (Lilliaceae) has long been used as a remedy in many cultures. Aloe products, which include the latex, gel, and whole leaf, are used, among other reasons, as laxatives, in creams for skin ailments, and as a treatment ...
  • Medicinal plants with cholinesterase inhibitory activity : a review 
    Adewusi, Emmanuel Adekanmi; Moodley, N.; Steenkamp, Vanessa (Academic Journals, 2010-12)
    Alzheimer’s disease (AD), a common neurodegenerative disease, is characterized by low levels in the brain of the neurotransmitter, acetylcholine (ACh). Clinical treatment of this disease is palliative and relies mostly ...