Browsing Neurology by Subject "Parkinson’s disease (PD)"

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Clinical findings and genetic screening for copy number variation mutations in a cohort of South African patients with Parkinson’s disease

Mahne, A.C.; Carr, J.A.; Bardien, S.; Schutte, Clara-Maria (Health and Medical Publishing Group, 2016-06)

BACKGROUND. Parkinson’s disease (PD), with a prevalence of up to 4% in Western countries, appears to be less common in Africa, possibly in part because of genetic factors. African studies investigating the genetic causation ...
Eryptosis as a marker of Parkinson’s disease

Pretorius, Etheresia; Swanepoel, A.C. (Albe Carina); Buys, A.V. (Antonia Vergina); Vermeulen, Natasha; Duim, Wiebren; Kell, Douglas B. (Impact Journals, 2014-10)

A major trend in recent Parkinson’s disease (PD) research is the investigation of biological markers that could help in identifying at‐risk individuals or to track disease progression and response to therapies. Central ...
Frequency of the LRRK2 G2019S mutation in South African patients with Parkinson’s disease

Du Toit, Nicola; Van Coller, Riaan; Anderson, David G.; Carr, Jonathan; Bardien, Soraya (Springer, 2019-10)

G2019S in LRRK2 is the most common mutation associated with Parkinson’s disease (PD). Highest frequencies are in North African Arabic (30–41%) and Ashkenazi Jewish (6–30%) populations, mostly due to founder effects. Here, ...
A putative founder effect for Parkinson's disease in South African Afrikaners

Carr, Jonathan; Van Coller, Riaan (Health and Medical Publishing Group, 2014-06)

Neurodegenerative diseases are important causes of disability and death, with prominent examples including Alzheimer’s disease, Parkinson’s disease (PD) and motor neuron disease. Although familial clustering of these ...
Screening of the glucocerebrosidase (GBA) gene in South Africans of African ancestry with Parkinson's disease

Mahungu, Amokelani C.; Anderson, David G.; Rossouw, Anastasia C.; Van Coller, Riaan; Carr, Jonathan A.; Ross, Owen A.; Bardien, Soraya (Elsevier, 2020-04)

Sequence variants in glucocerebrosidase (GBA) are a major genetic risk factor for Parkinson's disease (PD), and display ethnic-dependent frequencies, for example, variants such as p.N370S and 84insGG are common in Ashkenazi ...
South African guideline on deep brain stimulation for Parkinson’s disease

Anderson, D.G.; Van Coller, Riaan; Carr, J. (Health and Medical Publishing Group, 2017-11)

BACKGROUND : Parkinson’s disease (PD) is a common neurodegenerative disease, associated with severe impairment of quality of life. Although the motor aspects of the illness are typically successfully treated with medications ...

Now showing items 1-6 of 6

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Browsing Neurology by Subject "Parkinson’s disease (PD)"

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