Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine,
in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis
(TB) has contributed to improved outcomes, ...
Theron, Annette J.; Anderson, Ronald; Madzime, Morris; Rossouw, Theresa M.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Cholo, Moloko C.; Kwofie, Luyanda Laura Illicia; Feldman, Charles; Tintinger, Gregory(MDPI, 2022-12-19)
There is increasing awareness of an association between the uptake of the HIV integrase inhibitor,
dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development
of the metabolic syndrome, ...
Tintinger, Gregory Ronald; Theron, Annette J.; Steel, Helen C.; Cholo, Moloko C.; Nel, Jan Gert; Feldman, Charles; Anderson, Ronald(MDPI, 2021-02-26)
Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB),
concerns remain about the cardiotoxic potential of this agent, albeit by unexplored
mechanisms. Accordingly, we have investigated ...
