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Browsing Research Articles (Internal Medicine) by UP Author "Anderson, Ronald"
Now showing items 1-20 of 36
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Van der Mescht, Mieke Adri; De Beer, Zelda; Steel, Helen C.; Anderson, Ronald; Masenge, Andries; Moore, Penny L.; Bastard, Paul; Casanova, Jean-Laurent; Abdullah, Fareed; Ueckermann, Veronica; Rossouw, Theresa M. (Elsevier, 2024-09)The African continent reported the least number of COVID-19 cases and deaths of all the continents, although the exact reasons for this are still unclear. In addition, little is known about the immunological profiles ...
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Nel, Jan Gert; Tintinger, Gregory Ronald (MDPI Publishing, 2020-12)This study probed the di erential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 50-diphosphate (ADP, 100 mol L1) ...
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Anderson, Ronald; Tintinger, Gregory Ronald; Cockeran, Riana; Potjo, Moliehi; Feldman, Charles (Molecular Diversity Preservation International, 2010-05)In general antibiotics interact cooperatively with host defences, weakening and decreasing the virulence of microbial pathogens, thereby increasing vulnerability to phagocytosis and eradication by the intrinsic antimicrobial ...
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Cockeran, Riana; Mutepe, Ndiafhi Daphney; Theron, Annette J.; Tintinger, Gregory Ronald; Steel, Helen C.; Stivaktas, Paraskevi Irene; Richards, Guy A.; Feldman, Charles; Anderson, Ronald (Oxford University Press, 2012)OBJECTIVES: Tigecycline is the prototype of the recently introduced, intravenously administered glycylcycline class of antibiotics, developed in response to the increasing problem of antibiotic resistance in Gram-positi ...
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Cigarette smoke condensate attenuates phorbol ester-mediated neutrophil extracellular trap formation Bokaba, Refilwe Philadelphia; Anderson, Ronald; Theron, Annette J.; Tintinger, Gregory Ronald (Makerere University Medical School, 2017-09)BACKGROUND : Neutrophil extracellular traps (NETs) constitute a network of chromatin fibres containing histone and antimicrobial peptides that are released by activated neutrophils. NETs protect the host against infection ...
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Ally, Mahmood Moosa Tar Mahomed; Hodkinson, Bridget; Meyer, Pieter Willem Adriaan; Musenge, Eustasius; Tintinger, Gregory Ronald; Tikly, Mohammed; Anderson, Ronald (BioMed Central, 2015-05-29)BACKGROUND : To measure circulating anti-citrullinated peptide antibodies (ACPA) and cytokines pre- and 6 months post-therapy as a strategy to predict and optimize responses to traditional disease-modifying antirheumatic ...
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Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
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Van der Mescht, Mieke Adri; Steel, Helen C.; De Beer, Zelda; Abdullah, Fareed; Ueckermann, Veronica; Anderson, Ronald; Rossouw, Theresa (Frontiers Media, 2023-08-14)INTRODUCTION : SARS-CoV-2 elicits a hyper-inflammatory response that contributes to increased morbidity and mortality in patients with COVID-19. In the case of HIV infection, despite effective anti-retroviral therapy, ...
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Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Hodkinson, Bridget; Anderson, Ronald; Tikly, Mohammed (Springer, 2018-06)PURPOSE : A retrospective comparison of the prevalence and diagnostic value of anti-Sa, anti-CEP-1, and anti-MCV autoantibodies relative to those of the established autoantibodies, composite RF and anti-CCP-IgG used routinely ...
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Richards, G.A.; Theron, Annette J.; Van den Bout, Jan Iman; Anderson, Ronald; Feldman, Charles; Van Zyl Smit, Richard; Chang, Ju-Wei; Tintinger, Gregory (European Respiratory Society, 2023-05)BACKGROUND : Electronic cigarettes (ECs) are electronic aerosol delivery systems composed of nicotine and various chemicals, which are widely used to facilitate smoking cessation. Although ECs are considered safer than ...
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Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Hodkinson, Bridget; Anderson, Ronald; Tikly, Mohammed (Makerere University Medical School, 2018-06)BACKGROUND : The immunoglobulin A isotypes of anti-cyclic citrullinated peptide antibodies (ACPA) and rheumatoid factor (RF) are associated with disease severity and progression in Caucasian rheumatoid arthritis (RA) ...
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Madzime, Morris; Theron, Annette J.; Anderson, Ronald; Tintinger, Gregory; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Nel, Jan Gert; Feldman, Charles; Rossouw, Theresa M. (Taylor and Francis, 2022)Please read abstract in the article.
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Richards, Guy A.; Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (MDPI Publishing, 2018-05-14)Dabigatran is an oral direct thrombin inhibitor, and rivaroxaban, a factor Xa inhibitor. Dabigatran has been implicated in the etiology of acute coronary syndromes and as these occur following inflammatory changes in the ...
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Potjo, Moliehi; Cockeran, Riana; Theron, Annette J.; Feldman, Charles; Anderson, Ronald (Molecular Diversity Preservation International, 2010)Moxifloxacin is useful in the treatment of respiratory infections, including community-acquired pneumonia, and also shows promise in the treatment of tuberculosis, a clinical setting which necessitates extended administration ...
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Theron, Annette J.; Feldman, Charles; Richards, Guy A.; Tintinger, Gregory Ronald; Anderson, Ronald (AME Publishing Company, 2019-12)Although the usage of electronic (e)-cigarettes (EC) and similar devices has gained in popularity as an apparent smoking cessation strategy, serious concerns are emerging in relation to both the efficacy of this strategy, ...
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Hodkinson, Bridget; Musenge, Eustasius; Ally, Mahmood Moosa Tar Mahomed; Meyer, Pieter Willem Adriaan; Anderson, Ronald; Tikly, Mohammed (Informa Healthcare, 2012-10)BACKGROUND: The severity and predictors of functional disability and health-related quality of life (HRQoL) in a cohort of South Africans with early RA were investigated. METHODS: Changes in the Health Assessment ...
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Tintinger, Gregory Ronald; Feldman, Charles; Theron, Annette J.; Anderson, Ronald (Hindawi Publishing Corporation, 2010-12-14)The prototype cysteinyl leukotriene receptor antagonist, montelukast, is generally considered to have a niche application in the therapy of exercise- and aspirin-induced asthma. It is also used as add-on therapy in patients ...
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Gravett, Cornelia M.; Tintinger, Gregory Ronald; Theron, Annette J.; Anderson, Ronald; Feldman, Charles; Green, Robin J. (Libertas Academica, 2010)The prototype cysteinyl leukotriene receptor antagonist, montelukast, is generally considered to have a niche application in the chemotherapy of exercise-induced asthma. It has also been used as add-on therapy in patients ...
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Nel, Jan Gert; Theron, Annette J.; Pool, Roger; Durandt, Chrisna; Tintinger, Gregory Ronald; Anderson, Ronald (AOSIS OpenJournals, 2016-01)The human innate immune system is indispensable for protection against potentially invasive microbial and viral pathogens, either neutralising them or containing their spread until effective mobilisation of the slower, adaptive ...
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Nel, Jan Gert; Theron, Annette J.; Durandt, Chrisna; Tintinger, Gregory Ronald; Pool, Roger; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Wiley, 2016-06)The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood neutrophils ...
Now showing items 1-20 of 36