Browsing Internal Medicine by Subject "Cell cycle"

Browsing Internal Medicine by Subject "Cell cycle"

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  • Efavirenz and lopinavir/ritonavir alter cell cycle regulation in lung cancer 
    Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Frontiers Media, 2020-08)
    Highly active anti-retroviral treatment (HAART) is currently the most effective treatment for HIV/AIDS. Additionally, HIV positive patients receiving HAART have a better health-related quality of life (HRQoL). Cancers ...
  • Efavirenz induces DNA damage response pathway in lung cancer 
    Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Impact Journals, 2020-10)
    The cell-cycle related genes are potential gene targets in understanding the effects of efavirenz (EFV) in lung cancer. The present study aimed at investigating the expression changes of cell-cycle related genes in ...
  • Pathway mapping reveals antiretroviral treatments' targeted cell cycle regulation in lung cancer 
    Marima, Rahaba; Hull, Rodney; Kandhavelu, Jeyalakshmi; Dlamini, Zodwa; Penny, Clement (Elsevier, 2020)
    The human cell cycle is a tightly regulated process with checkpoints in place to ensure genomic integrity. Cyclin/cyclin dependent kinases (CDKs) complexes drive the progression of the cell cycle while CDK-inhibitors (CDKIs) ...