Browsing Internal Medicine by Subject "Calcium fluxes"

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Dolutegravir potentiates platelet activation by a calcium-dependent, ionophore-like mechanism

Madzime, Morris; Theron, Annette J.; Anderson, Ronald; Tintinger, Gregory; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Nel, Jan Gert; Feldman, Charles; Rossouw, Theresa M. (Taylor and Francis, 2022)

Please read abstract in the article.
Submission for special issue : The role of platelet activation in the pathophysiology of HIV, tuberculosis, and pneumococcal disease. Bedaquiline suppresses ADP-mediated activation of human platelets in vitro via interference with phosphatidylinositol 3-kinase

Tintinger, Gregory Ronald; Theron, Annette J.; Steel, Helen C.; Cholo, Moloko C.; Nel, Jan Gert; Feldman, Charles; Anderson, Ronald (MDPI, 2021-02-26)

Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB), concerns remain about the cardiotoxic potential of this agent, albeit by unexplored mechanisms. Accordingly, we have investigated ...

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