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Browsing Internal Medicine by Author "Tintinger, Gregory Ronald"
Now showing items 21-30 of 30
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Nel, Jan Gert; Theron, Annette J.; Durandt, Chrisna; Tintinger, Gregory Ronald; Pool, Roger; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Wiley, 2016-06)The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood neutrophils ...
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Nel, Jan Gert; Durandt, Chrisna; Theron, Annette J.; Tintinger, Gregory Ronald; Pool, Roger; Richards, Guy A.; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Elsevier, 2017-06)OBJECTIVES: Platelets orchestrate the inflammatory activities of neutrophils, possibly contributing to pulmonary and myocardial damage during severe pneumococcal infection. This study tested the hypothesis that the ...
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Nel, Jan Gert; Durandt, Chrisna; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald; Tintinger, Gregory Ronald (Springer, 2016-08)This study has explored the role of the pneumococcal toxin, pneumolysin (Ply), in activating human platelets. Following exposure to Ply [10–80 nanograms (ng)/ml], platelet activation and cytosolic Ca2+ concentrations ...
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Tintinger, Gregory Ronald; Theron, Annette J.; Steel, Helen C.; Cockeran, Riana; Pretorius, Lynette; Anderson, Ronald (BioMed Central, 2009-10)BACKGROUND: The role of protein kinase C (PKC) in regulating the activity of phospholipase C (PLC) in neutrophils activated with the chemoattractant, platelet-activating factor (PAF, 20 and 200 nM), was probed in the current ...
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Rapoport, Bernardo Leon; Shannon, Vickie R.; Cooksley, Tim; Johnson, Douglas B.; Anderson, Lindsay; Blidner, Ada Gabriela; Tintinger, Gregory Ronald; Anderson, Ronald (Frontiers Media, 2021-10)The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, with agents such as nivolumab, pembrolizumab, and cemiplimab targeting programmed cell death protein-1 (PD-1) and durvalumab, ...
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Tintinger, Gregory Ronald; Theron, Annette J.; Anderson, Ronald; Potjo, Moliehi (Elsevier, 2007-06-15)Please refer to abstract in article
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Tintinger, Gregory Ronald; Laubscher, C.; Fickl, H.; Anderson, Ronald (Health and Medical Publishing Group, 2010-07)OBJECTIVES: The study was designed to evaluate the role of soluble triggering receptor expressed on myeloid cells (s-TERM-1) measured in samples of endotracheal aspirates from critically ill, intubated patients as a marker ...
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Tintinger, Gregory Ronald; Van der Merwe, J.J.; Ficki, H.; Rheeder, Paul; Feldman, Charles; Anderson, Ronald (Springer, 2012-01)Soluble triggering receptor expressed on myeloid cells is upregulated on the surface of inflammatory cells in the presence of bacterial infections apparently excluding those due to Mycobacterium tuberculosis. Therefore, ...
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Tintinger, Gregory Ronald; Theron, Annette J.; Steel, Helen C.; Cholo, Moloko C.; Nel, Jan Gert; Feldman, Charles; Anderson, Ronald (MDPI, 2021-02-26)Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB), concerns remain about the cardiotoxic potential of this agent, albeit by unexplored mechanisms. Accordingly, we have investigated ...
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Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Tikly, Mohammed; Tintinger, Gregory Ronald; Winchow, Lai Ling; Steel, Helen C.; Anderson, Ronald (Hindawi Publishing, 2019)Microbial lipopolysaccharides (LPS) have been implicated in the pathogenesis of rheumatoid arthritis (RA), possibly driving a systemic inflammatory response that may trigger the development and/or exacerbation of the ...
Now showing items 21-30 of 30