Browsing Research Articles (Paediatrics and Child Health) by Title

Browsing Research Articles (Paediatrics and Child Health) by Title

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  • Dealing with spirometry in children under six years of age : challenges and opportunities in asthmatics 
    De Campos, Katya; Masekela, Refiloe (Allergy Society of South Africa, 2014-03)
    Pulmonary function tests are essential in the diagnosis of asthma but these are seldom performed in preschool children. Although pulmonary function tests are critical to the diagnosis and follow up of asthmatics, there ...
  • Decreased severity of disease during the first global Omicron variant COVID-19 outbreak in a large hospital in Tshwane, South Africa 
    Abdullah, Fareed; Myers, J.; Basu, Debashis; Tintinger, Gregory; Ueckermann, Veronica; Mathebula, M.; Ramlall, R.; Spoor, S.; De Villiers, T.; Van der Walt, Z.; Cloete, Jeane; Soma-Pillay, Priya; Rheeder, Paul; Paruk, Fathima; Engelbrecht, Adel; Lalloo, Vidya; Myburg, M.; Kistan, J.; Van Hougenhouck-Tulleken, Wesley G.; Boswell, Michael T.; Gray, G.; Welch, R.; Blumberg, Lucille Hellen; Jassat, W. (Elsevier, 2022-03)
    INTRODUCTION : The coronavirus disease 2019 (COVID-19) first reported in Wuhan, China in December 2019 is a global pandemic that is threatening the health and wellbeing of people worldwide. To date there have been more ...
  • Development of a subaortic aneurysm secondary to disseminated tuberculosis in a child 
    Takawira, Farirai F.; Joshi, Jayneel A.; Du Plessis, Dirk J. (Elsevier, 2010-08)
    Subvalvular aneurysms of the left ventricle are very rare and often the cause is uncertain. Most of the cases of subvalvular left ventricular aneurysms described in the literature are due to congenital weakness of the ...
  • Diagnosing and managing childhood asthma effectively with limited resources 
    Van Niekerk, Andre; Weinberg, Eugene G. (Allergy Society of South Africa, 2023-03)
    Childhood asthma must be diagnosed and managed correctly. It is the most common and potentially fatal chronic noncommunicable disease in children. The prevalence of asthma is increasing in both resource-limited and ...
  • Diagnosing childhood-onset inborn errors of metabolism by next generation sequencing 
    Ghosh, Arunabha; Schlecht, Helene; Heptinstall, Lesley E.; Bassett, John K.; Cartwright, Eleanor; Bhaskar, Sanjeev; Urquhart, Jill; Broomfield, Alexander; Morris, Andrew A.M.; Jameson, Elisabeth; Schwahn, Bernd C.; Walter, John H.; Douzgou, Sofia; Murphy, Helen; Hendriksz, Christian J.; Sharma, Reena; Wilcox, Gisela; Crushell, Ellen; Monavari, Ardeshir A.; Martin, Richard; Doolan, Anne; Senniappan, Senthil; Ramsden, Simon C.; Jones, Simon A.; Banka, Siddharth (BMJ Publishing Group, 2017-11)
    BACKGROUND : Inborn errors of metabolism (IEMs) underlie a substantial proportion of paediatric disease burden but their genetic diagnosis can be challenging using the traditional approaches. METHODS : We designed and ...
  • Diagnosis and management of community-acquired pneumonia in children : South African Thoracic Society guidelines 
    Zar, Heather J.; Moore, D.P.; Andronikou, S.; Argent, A.C.; Avenant, Theunis Johannes; Cohen, C.; Green, Robin J.; Itzikowitz, G.; Jeena, P.; Masekela, R.; Nicol, M.P.; Pillay, A.; Reubenson, G.; Madhi, S.A. (South African Medical Association, 2020-09)
    BACKGROUND: Pneumonia remains a major cause of morbidity and mortality amongst South African children. More comprehensive immunisation regimens, strengthening of HIV programmes, improvement in socioeconomic conditions and ...
  • The diagnosis and management of congenital pulmonary valve stenosis 
    Mitchell, Belinda J.; Mhlongo, M. (South African Heart Association, 2018)
    Congenital pulmonary stenosis (PS) is one of the most prevalent congenital cardiac abnormalities. A thorough assessment is needed to determine which of the many patients born with PS, will need intervention and further ...
  • The diagnosis of asthma in children : an evidence-based approach to a common clinical dilemma 
    Masekela, R.; Risenga, S.M.; Kitchin, Omolemo P.; White, D.A.; Davis, G.; Goussard, P.; Manjra, Ahmed I.; Kritzinger, F.E.; Levin, M.; Zar, Heather J.; Green, Robin J. (Health and Medical Publishing Group, 2018-07)
    BACKGROUND : Asthma is a heterogeneous condition characterised by chronic inflammation and variable expiratory airflow limitation, as well as airway reversibility. The diagnosis of asthma in young children is limited by ...
  • Diagnosis of atopic dermatitis : from bedside to laboratory 
    Sinclair, Werner; Aboobaker, J.; Green, Robin J.; Levin, M.E. (Health and Medical Publishing Group, 2014-10)
    Atopic dermatitis (AD) is essentially diagnosed clinically. In babies and young children, the diagnosis is usually straightforward. Dry, very pruritic dermatitis starts on the cheeks, with the neck and trunk often involved, ...
  • Diagnosis of community-acquired pneumonia in children : South African Thoracic Society guidelines (part 2) 
    Zar, Heather J.; Moore, D.P.; Itzikowitz, G.; Green, Robin J.; Argent, A.C.; Avenant, Theunis Johannes; Cohen, C.; Jeena, P.; Masekela, R.; Pillay, A.; Reubenson, G.; Madhi, S.A.; Andronikou, S.; Nicol, M.P. (Health and Medical Publishing Group, 2020-07)
    BACKGROUND. Accurate diagnosis and attribution of the aetiology of pneumonia are important for measuring the burden of disease, implementing appropriate treatment strategies and developing more effective interventions. ...
  • Diagnosis of food allergy : history, examination and in vivo and in vitro tests 
    Van der Spuy, D.A.; Terblanche, Alta J.; Karabus, S.; Kriel, M.; Manjra, Ahmed I.; Goddard, E.; Gray, Claudia L.; Lang, A.C.; Risenga, Samuel Malamulele; Levin, M.E. (Health and Medical Publishing Group, 2015-01)
    One cannot depend on one single test to diagnose food allergy. A detailed history is an essential initial step in cases of suspected food allergy. Aspects of the history should be gathered separately for each food being ...
  • Diagnosis, monitoring and treatment of tuberous sclerosis complex : a South African consensus response to international guidelines 
    De Vries, P.J.; Leclezio, L.; Wilmshurst, J.M.; Fieggen, G.; Gottlich, E.; Jacklin, L.; Naiker, I.P.; Newaj, R.; Shamley, D.; Schlegel, B.; Venter, A. (Health and Medical Publishing Group, 2017-05)
    Tuberous sclerosis complex (TSC) is a genetic disorder with multi-system manifestations and a high burden of disease. In 2013, an international panel of TSC experts revised the guidelines for the diagnosis, surveillance ...
  • A diagnostic approach to recurrent respiratory tract infections in childhood : could it be primary immunodeficiency? 
    Van Niekerk, Andre; Esser, M. (Allergy Society of South Africa, 2015-12)
    The recurrence of respiratory tract infections is a common problem in paediatric practice. Parental concerns around recurrent respiratory infections (RRTI) contribute significally towards doctor visits. This a a surprising ...
  • Diagnostic testing practices for diarrhoeal cases in South African public hospitals 
    Johnstone, Siobhan; Page, Nicola Anne; Groome, Michelle J.; Du Plessis, Nicolette Marie; Thomas, Juno (BMC, 2022-11-09)
    BACKGROUND : Stool samples submitted for diagnostic testing represent a proportion of diarrhoeal cases seeking healthcare, and an even smaller proportion of diarrhoeal cases in the community. Despite this, surveillance ...
  • Diagnostic tests for Niemann-pick disease type C (NP-C) : a critical review 
    Hendriksz, Christian J.; Vanier, Marie T.; Bauer, Peter; Coll, Maria J.; Burlina, Alberto; Latour, Philippe; Goizet, Cyril; Welford, Richard W.D.; Marquardt, Thorsten; Kolb, Stefan A.; Bauer, Peter (Elsevier, 2016-08)
    Niemann-Pick disease type C (NP-C) is a neurovisceral lysosomal cholesterol trafficking and lipid storage disorder caused by mutations in one of the two genes, NPC1 or NPC2. Diagnosis has often been a difficult task, due ...
  • Differences in Niemann-Pick disease type C symptomatology observed in patients of different ages 
    Mengel, Eugen; Pineda, Mercedes; Hendriksz, Christian J.; Walterfang, Mark; Torres, Juan V.; Kolb, Stefan A. (Elsevier, 2017-03)
    BACKGROUND : Niemann-Pick disease Type C (NP-C) is a genetic lipid storage disorder characterised by progressive neurovisceral symptomatology. Typically, disease progression ismore pronounced in patientswith early onset ...
  • The dilemma of diagnosing coenzyme Q10 deficiency in muscle 
    Louw, Roan; Smuts, Izelle; Wilsenach, Kimmey-Li; Jonck, Lindi-Maryn; Schoonen, Maryke; Van der Westhuizen, Francois H. (Elsevier, 2018-09)
    BACKGROUND : Coenzyme Q10 (CoQ10) is an important component of the mitochondrial respiratory chain (RC) and is critical for energy production. Although the prevalence of CoQ10 deficiency is still unknown, the general ...
  • The Diploma in Allergology - levels of competence required and new developments 
    Green, Robin J.; Kling, Sharon (Allergy Society of South Africa, 2011-08)
    This article describes the history of the Diploma in Allergy, provides an outline of the requirements and its purpose and discusses future developments.
  • Disagreement between common measures of asthma control in children 
    Green, Robin J.; Klein, Max; Becker, Piet J.; Halkas, Andrew; Lewis, Humphrey; Kitchin, Omolemo P.; Moodley, Teshni; Masekela, Refiloe (American College of Chest Physicians, 2013-01)
    BACKGROUND: Asthma is a worldwide problem. It cannot be prevented or cured, but it is possible, at least in principle, to control asthma with modern management. Control usually is assessed by history of symptoms, physical ...
  • Disclosure of a putative biosignature for respiratory chain disorders through a metabolomics approach 
    Smuts, Izelle; Van der Westhuizen, Francois Hendrikus; Louw, Roan; Mienie, Lodewyk J.; Engelke, Udo F.H.; Wevers, Ron A.; Mason, Shayne; Koekemoer, Gerhard; Reinecke, Carolus J. (Springer, 2013-04)
    The diagnosis of respiratory chain deficiencies (RCDs) is complicated and the need for a diagnostic biomarker or biosignature has been widely expressed. In this study, the metabolic profile of a selected group of 29 ...