Browsing Nuclear Medicine by Title

Browsing Nuclear Medicine by Title

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  • [68ga]ga-pentixafor for pet imaging of vascular expression of cxcr-4 as a marker of arterial inflammation in hiv-infected patients : a comparison with18f[fdg] pet imaging 
    Lawal, Ismaheel Opeyemi; Popoola, Gbenga O.; Mahapane, Johncy; Kaufmann, Jens; Davis, Cindy; Ndlovu, Honest; Maserumule, Letjie C.; Mokoala, Kgomotso M.G.; Bouterfa, Hakim; Wester, Hans-Jurgen; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2020-12)
    People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we ...
  • 89Zr-Leukocyte labelling for cell trafficking : in vitro and preclinical investigations 
    Kahts, Maryke; Guo, Hua; Kommidi, Harikrishna; Yang, Yanping; Sayman, Haluk Burcak; Summers, Beverley; Ting, Richard; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Aras, Omer (SpringerOpen, 2023-11-06)
    BACKGROUND : The non-invasive imaging of leukocyte trafficking to assess inflammatory areas and monitor immunotherapy is currently generating great interest. There is a need to develop more robust cell labelling and ...
  • Aberrant vascular anatomy associated with artifactual focal avidity in the liver on PSMA PET 
    Lawal, Ismaheel Opeyemi; Pectasides, Melina; Parihar, Ashwin Singh; Shah, Hardik U.; Halkar, Raghuveer K.; Jani, Ashesh B.; Schuster, David M. (Lippincott Williams and Wilkins, 2023-09)
    68Ga–prostate-specific membrane antigen (PSMA) PET/CT is a valuable tool for staging and restaging of prostate cancer. Prostate-specific membrane antigen expression is not specific to prostate cancer, as it is expressed ...
  • Accuracy of bone SPECT/CT for identifying hardware loosening in patients who underwent lumbar fusion with pedicle screws 
    Hudyana, Hendrah; Maes, Alex; Vandenberghe, Thierry; Fidlers, Luc; Sathekge, Mike Machaba; Nicolai, Daniel; Van de Wiele, Christophe (Springer, 2016-02)
    BACKGROUND : The aim of this retrospective study was to evaluate the accuracy of bone SPECT (single photon emission computed tomography)/CT (computed tomography) in diagnosing loosening of fixation material in patients ...
  • The added value of [F-18]FDG PET/CT in the management of invasive fungal infections 
    Ankrah, Alfred O.; Creemers-Schild, Dina; De Keizer, Bart; Klein, Hans C.; Dierckx, Rudi A.J.O.; Kwee, Thomas C.; Span, Lambert F.R.; De Jong, Pim A.; Sathekge, Mike Machaba; Glaudemans, Andor W.J.M. (MDPI, 2021-01-17)
    Anatomy-based imaging methods are the usual imaging methods used in assessing invasive fungal infections (IFIs). [18F]FDG PET/CT has also been used in the evaluation of IFIs. We assessed the added value of [18F]FDG PET/CT ...
  • Adjunctive use of statins for COVID-19 
    Sathekge, Mike Machaba; Byttebier, Geert; De Spiegeleer, Bart; Saxberg, Bo; Ueckermann, Veronica; Belmans, Luc; Alexander, Myriam; Fedson, David (MDPI, 2021-04-01)
    The interaction between obesity, cardiometabolic disorders and COVID-19 represents a syndemic that requires both social intervention and a multipharmacological approach. The risks associated with diabetes, obesity and ...
  • Advances in imaging of tuberculosis: the role of 18 F-FDG PET and PET/CT 
    Vorster, Mariza; Sathekge, Mike Machaba; Bomanji, Jamshed (Lippincott Williams and Wilkins, 2014-05)
    PURPOSE OF REVIEW : To review the main applications, advantages and limitations of 18F-FDG PET and PET/computed tomography (CT), and some other tracers in imaging of tuberculosis (TB). RECENT FINDINGS : In pulmonary TB, ...
  • Advances in PSMA alpha theragnostics 
    Vorster, Mariza; Sathekge, Mike Machaba (Elsevier, 2024-07)
    Alpha theranostics offer an attractive alternative form of therapy, which has best been investigated and documented with 225Ac-PSMA in patients with prostate cancer. Advantages offered by targeted alpha therapy include ...
  • Advances in radioligand theranostics in oncology 
    Lawal, Ismaheel Opeyemi; Abubakar, Sofiullah O.; Ndlovu, Honest; Mokoala, Kgomotso M.G.; More, Stuart; Sathekge, Mike Machaba (Springer, 2024-05)
    Please read abstract in the article.
  • Analytical characterization of NOTA-modified somatropins 
    Bracke, Nathalie; Wynendaele, Evelien; D’Hondt, Matthias; Haselberg, Rob; Somsen, Govert W.; Pauwels, Ewald; Van de Wiele, Christophe; De Spiegeleer, Bart (Elsevier, 2014-08)
    Chemical modification of biomolecules like the introduction of metal-chelators into proteins can lead to heterogeneous product formation. The nature and extend of the modification is important in interpreting the biological ...
  • Antibiotic-derived radiotracers for positron emission tomography : nuclear or “unclear” infection imaging? 
    Gouws, Arno Christiaan; Kruger, Hendrik Gerhardus; Gheysens, Olivier; Zeevaart, Jan Rijn; Govender, Thavendran; Naicker, Tricia; Ebenhan, Thomas (Wiley, 2022-11)
    The excellent features of non-invasive molecular imaging, its progressive technology (real-time, whole-body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography ...
  • Antimicrobial peptides : their role as infection-selective tracers for molecular imaging 
    Ebenhan, Thomas; Gheysens, Olivier; Kruger, Hendrik G.; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (Hindawi Publishing, 2014-08)
    Antimicrobial peptides (AMPs) are a heterogeneous class of compounds found in a variety of organisms including humans and, so far, hundreds of these structures have been isolated and characterised. They can be described ...
  • Appropriate indications for positron emission tomography/computed tomography : college of nuclear physicians of the colleges of medicine of South Africa 
    Sathekge, Mike Machaba; Warwick, J.M.; Doruyter, A.; Vorster, Mariza (Health and Medical Publishing Group, 2015-11)
    Individualised patient treatment approaches demand precise determination of initial disease extent combined with early, accurate assessment of response to treatment, which is made possible by positron emission tomography/computed ...
  • Appropriate indications for positron emission tomography/computed tomography, 2015 
    Vorster, Mariza; Doruyter, A.; Brink, A.; Mkhize, S.; Holness, J.; Malan, N.; Nyakale, Nozipho E.; Warwick, J.M.; Sathekge, Mike Machaba (Health and Medical Publishing Group, 2016-01)
    These recommendations are intended to serve an important and relevant role in advising referring physicians on the appropriate use of 18F-fluorodeoxyglucose (18F-FDG) and non-18F-FDG positron emission tomography/computed ...
  • Article towards facile radiolabeling and preparation of gallium-68-/bismuth-213-dota-[thi8, met(O2)11]-substance p for future clinical application : first experiences 
    Suthiram, Janine; Ebenhan, Thomas; Marjanovic-Painter, Biljana; Sathekge, Mike Machaba; Zeevaart, Jan Rijn (MDPI, 2021-08)
    Please read abstract in the article.
  • Association between plasma homocysteine and myocardial SPECT abnormalities in patients referred for suspected myocardial ischaemia 
    Ankrah, Alfred O.; Buscombe, John Richard; Sathekge, Mike Machaba (Clinics Cardiv, 2012-07)
    BACKGROUND: Elevated plasma homocysteine level has emerged as a relatively newly recognised risk factor for coronary artery disease (CAD). However, reduction of plasma homocysteine levels in large prospective studies did ...
  • An automated synthesis method for 68Ga-labelled ubiquicidin 29–41 
    Le Roux, Jannie; Rubow, Sietke; Ebenhan, Thomas; Wagener, Carl (Springer, 2020-01)
    Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated ...
  • Barriers and enablers for implementation of digital-linked diagnostics models at point-of-care in South Africa : stakeholder engagement 
    Moetlhoa, Boitumelo; Nxele, Siphesihle Robin; Maluleke, Kuhlula; Mathebula, Evans Mantiri; Marange, Musa; Chilufya, Maureen; Dzinamarira, Tafadzwa; Duah, Evans; Dzobo, Matthias; Kekana, Mable; Jaya, Ziningi Nobuhle; Thabane, Lehana; Dlangalala, Thobeka; Nyasulu, Peter S.; Hlongwana, Khumbulani;; Dlungwane, Thembelihle; Kgatle, Mankgopo; Gxekea, Nobuhle; Mashamba‑Thompson, Tivani Phosa (BMC, 2024-02)
    The integration of digital technologies holds significant promise in enhancing accessibility to disease diagnosis and treatment at point-of-care (POC) settings. Effective implementation of such interventions necessitates ...
  • Biodistribution and pharmacokinetics of I-131 labelled 4-Iodophenylacetic acid 
    Zeevaart, Jan Rijn; Szucs, Zoltan; Pulker, Tamsyn A.; Sello, Thato; Bracher, Jacqueline; Sathekge, Mike Machaba (Bentham Science, 2012-10-11)
    Phenylacetate has been reported to have a potent anti-proliferative and anti-differentiating effect in haematological malignancies and in solid tumours at non-toxic concentrations. This study is a preliminary investigation ...
  • Biological characterisation of somatropin-derived cryptic peptides 
    Tack, Liesa; Bracke, Nathalie; Verbeke, Frederick; Wynendaele, Evelien; Pauwels, Ewald; Maes, Alex; Van de Wiele, Christophe; Sathekge, Mike Machaba; De Spiegeleer, Bart (Springer, 2019-09)
    Little is known about possible cryptic peptides of the recombinant growth hormone (somatropin). In this study, six synthetic somatropin-derived peptides (SDPs) were selected based on their sequences which correspond to the ...