dc.contributor.author |
Mudau, Maanda
|
|
dc.contributor.author |
Jacobson, Rachael
|
|
dc.contributor.author |
Minenza, Nadia
|
|
dc.contributor.author |
Kuonza, Lazarus R.
|
|
dc.contributor.author |
Morris, Vida
|
|
dc.contributor.author |
Engelbrecht, Heather
|
|
dc.contributor.author |
Nicol, Mark P.
|
|
dc.contributor.author |
Bamford, Colleen
|
|
dc.contributor.editor |
Cornelis, Pierre |
|
dc.date.accessioned |
2013-05-17T09:12:31Z |
|
dc.date.available |
2013-05-17T09:12:31Z |
|
dc.date.issued |
2013-03-14 |
|
dc.description.abstract |
OBJECTIVE: To describe an outbreak of multi-resistant Pseudomonas aeruginosa bloodstream infections (MRPA-BSI) that
occurred in the haematology ward of a tertiary academic hospital in Cape Town, South Africa, and determine risk factors for
acquisition of MRPA-BSI.
METHODS: The outbreak investigation included a search for additional cases, review of patient records, environmental and
staff screening, molecular typing using pulsed-field gel electrophoresis (PFGE) and Multi-locus sequencing (MLST) and a
retrospective case-control study.
RESULTS: Ten MRPA-BSI cases occurred in the haematology ward between January 2010 and January 2011. The case fatality
rate was 80%. Staff screening specimens were negative for MRPA and an environmental source was not identified. PFGE
showed that 9/10 isolates were related. MLST showed that 3 of these 9 isolates belonged to Sequence type (ST) 233 while
the unrelated isolate belonged to ST260.
CONCLUSION: We have described an outbreak of MRPA-BSI occurring over an extended period of time among neutropenic
haematology patients. Molecular typing confirms that the outbreak was predominantly due to a single strain. The source of
the outbreak was not identified, but the outbreak appears to have been controlled following intensive infection control
measures. |
en_US |
dc.description.librarian |
am2013 |
en_US |
dc.description.sponsorship |
Nadia Minenza received financial support from the National Research Foundation, South Africa and from the University of Cape Town, South Africa
(both unrestricted educational grants). |
en_US |
dc.description.uri |
http://www.plosone.org |
en_US |
dc.identifier.citation |
Mudau M, Jacobson R, Minenza N, Kuonza L, Morris V, Engelbrecht, H, Nicol,MP &Bamford,C 2013, 'Outbreak of Multi-Drug Resistant Pseudomonas aeruginosa Bloodstream Infection in the Haematology Unit of a South African Academic Hospital', PLoS ONE, vol. 8, no. 3,: e55985. DOI: 10.1371/journal.pone.0055985 |
en_US |
dc.identifier.issn |
1932-6203 |
|
dc.identifier.other |
10.1371/journal.pone.0055985 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/21507 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Public Library of Science |
en_US |
dc.rights |
© 2013 Mudau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
en_US |
dc.subject |
Pseudomonas aeruginosa |
en_US |
dc.subject |
Multidrug-resistant (MDR) |
en_US |
dc.subject |
South African academic hospital |
en_US |
dc.subject |
Bloodstream infection |
|
dc.title |
Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the Haematology unit of a South African academic hospital |
en_US |
dc.type |
Article |
en_US |