Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the Haematology unit of a South African academic hospital

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dc.contributor.author Mudau, Maanda
dc.contributor.author Jacobson, Rachael
dc.contributor.author Minenza, Nadia
dc.contributor.author Kuonza, Lazarus R.
dc.contributor.author Morris, Vida
dc.contributor.author Engelbrecht, Heather
dc.contributor.author Nicol, Mark P.
dc.contributor.author Bamford, Colleen
dc.contributor.editor Cornelis, Pierre
dc.date.accessioned 2013-05-17T09:12:31Z
dc.date.available 2013-05-17T09:12:31Z
dc.date.issued 2013-03-14
dc.description.abstract OBJECTIVE: To describe an outbreak of multi-resistant Pseudomonas aeruginosa bloodstream infections (MRPA-BSI) that occurred in the haematology ward of a tertiary academic hospital in Cape Town, South Africa, and determine risk factors for acquisition of MRPA-BSI. METHODS: The outbreak investigation included a search for additional cases, review of patient records, environmental and staff screening, molecular typing using pulsed-field gel electrophoresis (PFGE) and Multi-locus sequencing (MLST) and a retrospective case-control study. RESULTS: Ten MRPA-BSI cases occurred in the haematology ward between January 2010 and January 2011. The case fatality rate was 80%. Staff screening specimens were negative for MRPA and an environmental source was not identified. PFGE showed that 9/10 isolates were related. MLST showed that 3 of these 9 isolates belonged to Sequence type (ST) 233 while the unrelated isolate belonged to ST260. CONCLUSION: We have described an outbreak of MRPA-BSI occurring over an extended period of time among neutropenic haematology patients. Molecular typing confirms that the outbreak was predominantly due to a single strain. The source of the outbreak was not identified, but the outbreak appears to have been controlled following intensive infection control measures. en_US
dc.description.librarian am2013 en_US
dc.description.sponsorship Nadia Minenza received financial support from the National Research Foundation, South Africa and from the University of Cape Town, South Africa (both unrestricted educational grants). en_US
dc.description.uri http://www.plosone.org en_US
dc.identifier.citation Mudau M, Jacobson R, Minenza N, Kuonza L, Morris V, Engelbrecht, H, Nicol,MP &Bamford,C 2013, 'Outbreak of Multi-Drug Resistant Pseudomonas aeruginosa Bloodstream Infection in the Haematology Unit of a South African Academic Hospital', PLoS ONE, vol. 8, no. 3,: e55985. DOI: 10.1371/journal.pone.0055985 en_US
dc.identifier.issn 1932-6203
dc.identifier.other 10.1371/journal.pone.0055985
dc.identifier.uri http://hdl.handle.net/2263/21507
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.rights © 2013 Mudau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_US
dc.subject Pseudomonas aeruginosa en_US
dc.subject Multi-drug resistance en_US
dc.subject South African Academic Hospital en_US
dc.subject Bloodstream Infection
dc.title Outbreak of multi-drug resistant Pseudomonas aeruginosa bloodstream infection in the Haematology unit of a South African academic hospital en_US
dc.type Article en_US


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