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Browsing Immunology by UP Author "Dodgen, Tyren Mark"
Now showing items 1-6 of 6
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Myburgh, Renier; Hochfeld, Warren Ernst; Dodgen, Tyren Mark; Ker, James A.; Pepper, Michael Sean (Elsevier, 2012-03)Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical ...
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Dodgen, Tyren Mark; Drögemöller, Britt I.; Wright, Galen E.B.; Warnich, Louise; Steffens, Francois E.; Cromarty, Allan Duncan; Alessandrini, Marco; Pepper, Michael Sean (Future Medicine, 2015-08)AIM : To align predicted and measured CYP2C19 phenotype in a South African cohort. MATERIALS AND METHODS : Genotyping of CYP2C19*2, *3, *9, *15, *17, *27 and *28 was performed using PCR-RFLP, and an Activity Score (AS) ...
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Chaudhry, Mamoonah; Alessandrini, Marco; Rademan, Jacobus; Dodgen, Tyren Mark; Steffens, Francois E.; Van Zyl, Danie G.; Gaedigk, Andrea; Pepper, Michael Sean (Future Medicine, 2017-03)AIM : Therapy with low-dose amitriptyline is commonly used to treat painful diabetic peripheral neuropathy. There is a knowledge gap, however, regarding the role of variable CYP2D6-mediated drug metabolism and side effects ...
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Dodgen, Tyren Mark; Hochfeld, Warren Ernst; Fickl, Heidi; Asfaha, Sahle M.; Durandt, Chrisna; Rheeder, Paul; Drögemoller, Britt I.; Wright, Galen E.B.; Warnich, Louise; Labuschagne, Christiaan D.J.; Van Schalkwyk, Antoinette; Gaedigk, Andrea; Pepper, Michael Sean (BioMed Central, 2013-01-29)BACKGROUND: Adverse drug reactions and lack of therapeutic efficacy associated with currently prescribed pharmacotherapeutics may be attributed, in part, to inter-individual variability in drug metabolism. Studies on ...
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Alessandrini, Marco; Chaudhry, Mamoonah; Dodgen, Tyren Mark; Pepper, Michael Sean (Mary Ann Liebert, 2016-10)In a move indicative of the enthusiastic support of precision medicine, the U.S. President Barack Obama announced the Precision Medicine Initiative in January 2015. The global precision medicine ecosystem is, thus, receiving ...
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Dodgen, Tyren Mark; Eloff, Arinda; Mataboge, C.K.; Roos, J.L. (Johannes Louw); Van Staden, C.W. (Werdie); Pepper, Michael Sean (Elsevier, 2015-04)BACKGROUND : Contradictory information exists regarding the influence of CYP2D6 polymorphisms on adverse drug reactions (ADRs) (extrapyramidal symptoms (EPS) and weight gain) related to risperidone treatment. This prompted ...
Now showing items 1-6 of 6