Browsing Immunology by Title

Browsing Immunology by Title

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  • Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus : putative underlying mechanistic cascade 
    Singh, Ankur; Lal, Bechan; Parkash, Jyoti; Millar, Robert P. (Elsevier, 2021-10)
    Unlike mammals, two kisspeptins genes encoding, kiss1 and kiss2 are detected in fishes with highly varied and contradictory difference in their reproductive activities. The present study was undertaken to examine the direct ...
  • Gender and sexual diversity – changing paradigms in an ever-changing world 
    Pepper, Michael Sean (Health and Medical Publishing Group, 2015-09)
    Enshrined in the Bill of Rights of South Africa's Constitution are a number of rights that affirm the democratic values of human dignity, equality and freedom. Section 9(3) states that 'The state may not unfairly discriminate ...
  • Gene and cell therapy in South Africa : current status and future prospects 
    Ely, Abdullah; Bloom, Kori; Maepa, Mohube Betty; Mahlangu, John N.; Pepper, Michael Sean; Arbuthnot, P. (Health and Medical Publishing Group, 2019-08)
    South Africa has a high disease burden resulting from communicable and non-communicable diseases. Current therapeutic interventions rarely result in a cure and the associated lifelong treatment places a considerable strain ...
  • The genetics of obesity : the role of the melanocortin 4 receptor 
    Logan, M.G.; Pepper, Michael Sean (Health and Medical Publishing Group, 2010)
    Obesity, which is described clinically by a body mass index (BMI) of > 30 kg/m2 is increasing at an alarming rate, and is recognised as a chronic disease by the World Health Organization (WHO). This epidemic decreases ...
  • Genome technologies, precision medicine and innovative therapies 
    Pepper, Michael Sean (Lynnwood Ridge: Academy of Science South Africa, 2018-09)
    We all share a common ancestry, and nowhere is this more apparent than in our genomes. Despite our differences, most of the information contained in our genomes is highly similar, if not identical. Yet it is the differences ...
  • Genomic sovereignty and the African promise : mining the African genome for the benefit of Africa 
    De Vries, Jantina; Pepper, Michael Sean (BMJ Publishing Group, 2012)
    Scientific interest in genomics in Africa is on the rise with a number of funding initiatives aimed specifically at supporting research in this area. Genomics research on material of African origin raises a number of ...
  • Gingival recession and localized aggressive periodontitis among HIV-infected children and adolescents receiving antiretroviral therapy 
    Blignaut, Elaine; Rossouw, Theresa M.; Becker, Piet J.; Mavuso, Diana S.; Feucht, Ute Dagmar (Lippincott Williams and Wilkins, 2019-06)
    BACKGROUND : Limited information is available on gingival recession or localized aggressive periodontitis among HIV-infected children and adolescents. This study reports on the prevalence of these conditions among children ...
  • A global comparative overview of the legal regulation of stem cell research and therapy : lessons for South Africa 
    Nothling-Slabbert, Melodie; Pepper, Michael Sean (Health and Medical Publishing Group, 2015-08)
    Stem cell research and its potential translation to regenerative medicine, tissue engineering and cell and gene therapy, have led to controversy and debates similar to the calls nearly 25 years ago for a ban involving ...
  • Glucocorticoids with or without fludrocortisone in septic shock : a narrative review from a biochemical and molecular perspective 
    Nethathe, Gladness D.; Lipman, Jeffrey; Anderson, Ronald; Fuller, Peter J.; Feldman, Charles (Elsevier, 2024-01)
    Two randomised controlled trials have reported a reduction in mortality when adjunctive hydrocortisone is administered in combination with fludrocortisone compared with placebo in septic shock. A third trial did not support ...
  • GnRH antagonists produce differential modulation of the signaling pathways mediated by GnRH receptors 
    Sperduti, Samantha; Limoncella, Silvia; Lazzaretti, Clara; Paradiso, Elia; Riccetti, Laura; Turchi, Sara; Ferrigno, Ilaria; Bertacchini, Jessika; Palumbo, Carla; Potì, Francesco; Longobardi, Salvatore; Millar, Robert P.; Simoni, Manuela; Newton, Claire L.; Casarini, Livio (MDPI Publishing, 2019-11-07)
    Commercial gonadotropin-releasing hormone (GnRH) antagonists di er by 1–2 amino acids and are used to inhibit gonadotropin production during assisted reproduction technologies (ART). In this study, potencies of three ...
  • Guideline for the diagnosis and treatment of chronic pancreatitis 
    Bornman, P.C.; Botha, J.F.; Ramos, J.M.; Smith, M.D.; Van der Merwe, S.; Watermeyer, G.A.; Ziady, C.C.M. (Health and Medical Publishing Group, 2010-12)
    BACKGROUND: Chronic pancreatitis (CP) is defined as a continuing inflammatory disease of the pancreas characterised by irreversible morphological changes, often associated with pain and with the loss of exocrine and/or ...
  • Guidelines for antiretroviral therapy in adults by the Southern African HIV clinicians society 
    Meintjes, Graeme; Maartens, Gary; Boulle, Andrew; Conradie, Francesca; Goemaere, Eric; Hefer, Eric; Johnson, Dave; Mathe, Moeketsi; Moosa, Yunus; Osih, Regina; Rossouw, Theresa M.; Van Cutsem, Gilles; Variava, Ebrahim; Venter, Francois; Spencer, Dave (Health and Medical Publishing Group, 2012-09)
    These guidelines are intended as an update to those published in the Southern African Journal of HIV Medicine in January 2008. Since the release of the previous guidelines, the scaleup of antiretroviral therapy (ART) ...
  • Haematopoietic stem cell transplantation in South Africa : current limitations and future perspectives 
    Grobbelaar, Simone; Mercier, Anne Elisabeth; Verburgh, Estelle; Brittain, David; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. HSCT provides life-changing and potentially curative therapy for a ...
  • Harmful interactions of non-essential heavy metals with cells of the innate immune system 
    Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (2012-04-16)
    In trace amounts, some heavy metals are essential for optimum health, while exposure to others, which are non-essential, presents the potential hazard of acute or chronic organ toxicity. Cadmium, mercury, lead, ...
  • HBV/HIV co-infection : the dynamics of HBV in South African patients with AIDS 
    Mayaphi, Simnikiwe Horatious; Rossouw, Theresa M.; Masemola, Difuro P.; Olorunju, Steve A.S.; Mphahlele, M. Jeffrey; Martin, Desmond J. (Health and Medical Publishing Group, 2012-03)
    OBJECTIVE: As sub-Saharan Africa is highly endemic for hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections, and their co-infection requires special management, we aimed to assess the serological and ...
  • HCV genotype 5 : epidemiology and spread of an uncommon genotype 
    Verbeeck, J.; Peigue-Lafeuille, H.; Ross, R.S.; Abergel, A.; Nevens, Frederik; Van der Merwe, Schalk Willem; Van Ranst, Marc; Henquell, C. (Elsevier, 2008-02)
  • Helicobacter pylori and gastric cancer 
    Fritz, Elongo Lekunze; Van der Merwe, Schalk Willem (Health and Medical Publishing Group, 2009-05)
    Gastric cancer is one of the most common forms of cancer worldwide, with an estimated 930 000 new cases diagnosed each year. It is thought to be more prevalent in men than in women. In South Africa the latest cancer ...
  • Hemangiomas - current therapeutic strategies 
    Mabeta, Peaceful Lucy; Pepper, Michael Sean (UBC Press, 2011-07)
    Hemangiomas are benign neoplasms of the vasculature frequently encountered in children. Several studies have shown that these tumors are characterized by excessive angiogenesis. Although benign, the lesions can present ...
  • Heterogeneity of cell therapy products 
    Wolmarans, Elize; Mellet, Juanita; Ambele, Melvin Anyasi; Durandt, Chrisna; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    Cellular therapy has become a billion-dollar industry and is set to become one of the therapeutic pillars of healthcare in the 21st century. Adult stem cells, which include haematopoietic stem and progenitor cells (HSPCs) ...
  • Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations 
    Ambele, Melvin Anyasi; Pepper, Michael Sean; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus (Wiley, 2019-05)
    BACKGROUND : Oral field cancerization describes a multifocal development process involving many cells at once in response to prolong exposure to carcinogens. This case demonstrated differential p16 expression in different ...