Browsing Immunology by Title

Browsing Immunology by Title

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  • Stem cell tourism in South Africa : a legal update 
    Nothling-Slabbert, Melodie; Pepper, Michael Sean; Mahomed, S. (Health and Medical Publishing Group, 2015-08)
    The past few years have seen a sharp rise in the propagation of unproven stem cell ‘treatments’, also known as ‘stem cell tourism’. Patients suffering from a variety of diseases unresponsive to conventional medical therapy ...
  • Step-by-step assembly and testing of a low-cost bioprinting solution for research and educational purposes 
    Honiball, John Robert; Pepper, Michael Sean; Prinsloo, Earl (Elsevier, 2021)
    Bioprinting is a rapidly expanding technology with the ability to fabricate in vitro three-dimensional (3D) tissues in a layer-by-layer manner to ultimately produce a living tissue which physiologically resembles native ...
  • Study on causes of fever in primary healthcare center uncovers pathogens of public health concern in Madagascar 
    Guillebaud, Julia; Bernardson, Barivola; Randriambolamanantsoa, Tsiry Hasina; Randrianasolo, Laurence; Randriamampionona, Jane Lea; Marino, Cesare Augusto; Rasolofo, Voahangy; Randrianarivelojosia, Milijaona; Vigan-Womas, Ines; Stivaktas, Voul; Venter, Marietjie; Piola, Patrice; Heraud, Jean-Michel (Public Library of Science, 2018-07-16)
    BACKGROUND : The increasing use of malaria diagnostic tests reveals a growing proportion of patients with fever but no malaria. Clinicians and health care workers in low-income countries have few tests to diagnose ...
  • Supportive care in patients with cancer during the COVID-19 pandemic 
    Aapro, Matti; Lyman, G.H.; Bokemeyer, C.; Rapoport, Bernardo Leon; Mathieson, N.; Koptelova, N.; Cornes, P.; Anderson, Ronald; Gascon, P.; Kuderer, N.M. (Elsevier, 2021)
    Cancer care has been profoundly impacted by the global pandemic of severe acute respiratory syndrome coronavirus 2 disease (coronavirus disease 2019, COVID-19), resulting in unprecedented challenges. Supportive care is an ...
  • Sustaining essential healthcare in Africa during the COVID-19 pandemic 
    Ongole, J.J.; Rossouw, Theresa M.; Fourie, P.B. (Petrus Bernardus); Stoltz, Anton Carel; Hugo, Johannes F.M.; Marcus, Tessa S. (International Union Against Tuberculosis and Lung Disease, 2020-06)
    No abstract available.
  • Synergies, tensions and challenges in HIV prevention, treatment and cure research : exploratory conversations with HIV experts in South Africa 
    Moodley, Keynthri; Rossouw, Theresa M.; Staunton, Ciara; Colvin, Christopher J. (BioMed Central, 2016-04-30)
    BACKGROUND : The ethical concerns associated with HIV prevention and treatment research have been widely explored in South Africa over the past 3 decades. However, HIV cure research is relatively new to the region ...
  • Systemic immune activation profiles of HIV-1 subtype C-infected children and their mothers 
    Makhubele, Tinyiko G.; Steel, Helen C.; Anderson, Ronald; Van Dyk, Gisela; Theron, Annette J.; Rossouw, Theresa M. (Hindawi Publishing, 2016)
    Little is known about immune activation profiles of children infected with HIV-1 subtype C. The current study compared levels of selected circulating biomarkers of immune activation in HIV-1 subtype C-infected untreated ...
  • Systemic immune dysregulation in early breast cancer is associated with decreased plasma levels of both soluble co-inhibitory and co-stimulatory immune checkpoint molecules 
    Rapoport, Bernardo Leon; Steel, Helen C.; Hlatshwayo, Nomsa; Theron, Annette J.; Meyer, Pieter Willem Adriaan; Nayler, Simon; Benn, Carol-Ann; Smit, Teresa; Kwofie, Luyanda Laura Illicia; Heyman, Liezl; Anderson, Ronald (Fronties Media SA, 2022-05-23)
    Breast cancer cells exploit the up-regulation or down-regulation of immune checkpoint proteins to evade anti-tumor immune responses. To explore the possible involvement of this mechanism in promoting systemic immunosuppression, ...
  • Systemic levels of the soluble co-inhibitory immune checkpoints, CTLA-4, LAG-3, PD-1/PD-L1 and TIM-3 are markedly increased in basal cell carcinoma 
    Malinga, Nonkululeko Z.; Siwele, Shalate C.; Steel, Helen C.; Kwofie, Luyanda Laura Illicia; Meyer, Pieter Willem Adriaan; Smit, Teresa; Anderson, Ronald; Rapoport, Bernardo Leon; Kgokolo, C.M. (Elsevier, 2022-05)
    Although co-inhibitory immune checkpoint proteins are primarily involved in promoting cell-cell interactions that suppress adaptive immunity, especially tumor immunity, the soluble cell-free variants of these molecules ...
  • T cell responses to SARS-CoV-2 spike cross-recognize Omicron 
    Keeton, Roanne; Tincho, Marius B.; Ngomti, Amkele; Baguma, Richard; Benede, Ntombi; Suzuki, Akiko; Khan, Khadija; Cele, Sandile; Bernstein, Mallory; Karim, Farina; Madzorera, Sharon V.; Moyo-Gwete, Thandeka; Mennen, Mathilda; Skelem, Sango; Adriaanse, Marguerite; Mutithu, Daniel; Aremu, Olukayode; Stek, Cari; Du Bruyn, Elsa; Van der Mescht, Mieke Adri; De Beer, Zelda; De Villiers, Talita R.; Bodenstein, Annie; Van den Berg, Gretha; Mendes, Adriano; Strydom, Amy; Venter, Marietjie; Giandhari, Jennifer; Naidoo, Yeshnee; Pillay, Sureshnee; Tegally, Houriiyah; Grifoni, Alba; Weiskopf, Daniela; Sette, Alessandro; Wilkinson, Robert J.; De Oliveira, Tulio; Bekker, Linda‑Gail; Gray, Glenda; Ueckermann, Veronica; Rossouw, Theresa; Boswell, M.T.; Bhiman, Jinal N.; Moore, Penny L.; Sigal, Alex; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Riou, Catherine (Nature Research, 2022-03-17)
    The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations1,2 that contribute to viral escape from antibody neutralization3–6 and reduce vaccine protection from infection7,8. The extent to which other ...
  • Tachykinin receptor-selectivity of the potential glioblastoma-targeted therapy, DOTA-[Thi8,Met(O2)11]-substance P 
    Suthiram, Janine; Pieters, Ane; Moosa, Zulfiah Mohamed; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Ebenhan, Thomas; Anderson, Ross Calley; Newton, Claire L. (MDPI, 2023-01)
    Please read abstract in article.
  • The tale of TILs in breast cancer : a report from the International Immuno-Oncology Biomarker Working Group 
    El Bairi, Khalid; Haynes, Harry R.; Blackley, Elizabeth; Fineberg, Susan; Shear, Jeffrey; Turner, Sophia; De Freitas, Juliana Ribeiro; Sur, Daniel; Amendola, Luis Claudio; Gharib, Masoumeh; Kallala, Amine; Arun, Indu; Azmoudeh-Ardalan, Farid; Fujimoto, Luciana; Sua, Luz F.; Liu, Shi-Wei; Lien, Huang-Chun; Kirtani, Pawan; Balancin, Marcelo; Attar, Hicham El; Guleria, Prerna; Yang, Wenxian; Shash, Emad; Chen, I-Chun; Bautista, Veronica; Do Prado Moura, Jose Fernando; Rapoport, Bernardo Leon; Castaneda, Carlos; Spengler, Eunice; Acosta-Haab, Gabriela; Frahm, Isabel; Sanchez, Joselyn; Castillo, Miluska; Bouchmaa, Najat; Zin, Reena R. Md; Shui, Ruohong; Onyuma, Timothy; Yang, Wentao; Husain, Zaheed; Willard-Gallo, Karen; Coosemans, An; Perez, Edith A.; Provenzano, Elena; Ericsson, Paula Gonzalez; Richardet, Eduardo; Mehrotra, Ravi; Sarancone, Sandra; Ehinger, Anna; Rimm, David L.; Bartlett, John M.S.; Viale, Giuseppe; Denkert, Carsten; Hida, Akira I.; Sotiriou, Christos; Loibl, Sibylle; Hewitt, Stephen M.; Badve, Sunil; Symmans, William Fraser; Kim, Rim S.; Pruneri, Giancarlo; Goel, Shom; Francis, Prudence A.; Inurrigarro, Gloria; Yamaguchi, Rin; Garcia-Rivello, Hernan; Horlings, Hugo; Afqir1, Said; Salgado, Roberto; Adams, Sylvia; Kok, Marleen; Vittoria Dieci, Maria; Michiels, Stefan; Demaria, Sandra; Loi, Sherene (Nature Research, 2021-12-01)
    The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes ...
  • Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion 
    Jackson, Carlo Stephan; Durandt, Chrisna; Janse van Rensburg, IIse; Praloran, Vincent; De la Grange, Philippe Brunet; Pepper, Michael Sean (Elsevier, 2017-05)
    Culture conditions used for the expansion of hematopoietic stemand progenitor cells (HSCs andHPCs, collectively HSPCs) should ideally favor the self renewal of long-termHSCs. At 20% O2, the synthesis of HIF-1α is balanced by ...
  • The role of Pref-1 in in vitro adipogenic differenctiation of mesenchymal stromal/stem cells 
    Da Silva, Carina Corte-Real (University of Pretoria, 2019)
    Obesity is characterized by an excessive amount of body fat which can negatively affect health as it is a risk factor for various non-communicable diseases such as cardiovascular disease and diabetes, amongst others. A ...
  • “They come and knock at the gate until the neighbours see”. Perceived barriers and benefits of implementing HIV care at the community level in Tshwane district : a qualitative study 
    Ngcobo, Sanele; Rossouw, Theresa M. (Public Library of Science, 2020-10)
    Little is known about the barriers and benefits of home-based HIV services offered by community health workers. These are especially important as the South African government embarks on scaling up community-based health ...
  • Tobacco-derived Lipopolysaccharide, not microbial translocation, as a potential contributor to the pathogenesis of rheumatoid arthritis 
    Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Tikly, Mohammed; Tintinger, Gregory Ronald; Winchow, Lai Ling; Steel, Helen C.; Anderson, Ronald (Hindawi Publishing, 2019)
    Microbial lipopolysaccharides (LPS) have been implicated in the pathogenesis of rheumatoid arthritis (RA), possibly driving a systemic inflammatory response that may trigger the development and/or exacerbation of the ...
  • Transcriptional analysis of the host response to HIV-1 infection in CD4+ T lymphocytes monocytes and macrophages 
    Wickham, Catherine Heather (University of Pretoria, 2019)
    The human immunodeficiency virus (HIV) is the causative agent of acquired immune deficiency syndrome (AIDS), a condition characterized by depletion of CD4+ T cells and other immune system dysfunctions. Due to its widespread ...
  • Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility 
    Gocz, Balazs; Rumpler, Eva; Sarvari, Miklos; Skrapits, Katalin; Takacs, Szabolcs; Farkas, Imre; Csillag, Veronika; Trinh, Sarolta H.; Bardoczi, Zsuzsanna; Solymosi, Norbert; Poliska, Szilard; Bartoloni, Lucia; Zouaghi, Yassine; Messina, Andrea; Pitteloud, Nelly; Anderson, Ross Calley; Millar, Robert P.; Quinton, Richard; Manchishi, Stephen M.; Colledge, William H.; Hrabovszky, Erik (National Academy of Sciences, 2022-06-28)
    Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian estrogen feedback regulating mammalian fertility. To reveal molecular mechanisms underlying this signaling, we thoroughly characterized ...
  • Transforming growth factor-β1 and soluble co-inhibitory immune checkpoints as putative drivers of immune suppression in patients with basal cell carcinoma 
    Kgokolo, C.M.; Malinga, Nonkululeko Z.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Smit, Teresa; Anderson, Ronald; Rapoport, Bernardo Leon (Elsevier, 2024-04)
    The current study compared the levels and possible associations between systemic soluble immune checkpoints (sICPs, n = 17) and a group of humoral modulators of immune suppressor cells ( n = 7) in a cohort of patients with ...
  • The transmission of Helicobacter pylori : the effects of analysis method and study population on inference 
    Delport, Wayne; Van der Merwe, Schalk Willem (Elsevier, 2007-04)
    Although much is known about the virulence of Helicobacter pylori, the transmission pathways for this bacterium are still unresolved. Transmission has been addressed through: (1) prevalence within families; (2) detection ...