Browsing Immunology by Title

Browsing Immunology by Title

Sort by: Order: Results:

  • A pivotal role for pneumolysin in the immunopathogenesis, treatment and prevention of pneumococcal disease 
    Feldman, Charles; Anderson, Ronald (Health & Medical Publishing Group, 2007-11)
    The pneumococcus remains an extremely important cause of morbidity and mortality worldwide. While the micro-organism has a number of significant virulence mechanisms, many recent studies have focused on pneumolysin, which ...
  • Plasma biomarkers of human immunodeficiency virus-related systemic inflammation and immune activation in Sub-Saharan Africa before and during suppressive antiretroviral therapy 
    Kroeze, Stefanie; Wit, Ferdinand W.; Rossouw, Theresa M.; Steel, Helen C.; Kityo, Cissy M.; Siwale, Margaret; Akanmu, Sulaimon; Mandaliya, Kishor; De Jager, Marleen; Ondoa, Pascale; Reiss, Peter; Rinke de Wit, Tobias F.; Kootstra, Neeltje; Hamers, Raph L. (Oxford University Press, 2019-09)
    We evaluated immune biomarker profiles in human immunodeficiency virus (HIV)–infected adults (n = 398) from 5 African countries. Although all biomarkers decreased after antiretroviral therapy (ART) initiation, levels of ...
  • Platelets and their role in the pathogenesis of cardiovascular events in patients with community-acquired pneumonia 
    Feldman, Charles; Anderson, Ronald (Frontiers Media, 2020-09)
    Community-acquired pneumonia (CAP) remains an important cause of morbidity and mortality throughout the world with much recent and ongoing research focused on the occurrence of cardiovascular events (CVEs) during the ...
  • Pneumococcal virulence factors in community-acquired pneumonia 
    Feldman, Charles; Anderson, Ronald (Lippincott, Williams & Wilkins, 2020-05)
    PURPOSE OF THE REVIEW: This manuscript reviews the recent literature related to new developments in the understanding of existing and novel virulence factors of the pneumococcus that are of potential importance in the ...
  • Pneumolysin as a potential therapeutic target in severe pneumococcal disease 
    Anderson, Ronald; Feldman, Charles (Elsevier, 2017-06)
    Acute pulmonary and cardiac injury remain significant causes of morbidity and mortality in those afflicted with severe pneumococcal disease, with the risk for early mortality often persisting several years beyond clinical ...
  • Pneumonia as a systemic illness 
    Feldman, Charles; Anderson, Ronald (Lippincott Williams and Wilkins, 2018-05)
    PURPOSE OF REVIEW : The manuscript reviews the recent literature describing the occurrence, risk factors, recognition and treatment of sepsis, respiratory failure, and multiple organ dysfunction in patients with ...
  • Polymerase chain reaction amplifying mycobacterial DNA from aspirates obtained by endoscopic ultrasound allows accurate diagnosis of mycobacterial disease in HIV-positive patients with abdominal lymphadenopathy 
    Nieuwoudt, Martin J.; Lameris, Roeland; Corcoran, Craig; Rossouw, Theresa M.; Slavik, Tomas; Du Plessis, Johannie; Omoshoro-Jones, Jones A.O.; Stivaktas, Paraskevi Irene; Potgieter, Fritz; Van der Merwe, Schalk Willem (Elsevier, 2014-09)
    Abdominal lymphadopathy in Human Immunodeficiency Virus (HIV) infection remains a diagnostic challenge. We performed a prospective cohort study recruiting thirty-one symptomatic HIV+ patients with abdominal lymphadenopathy ...
  • Practical approach to diagnosis and management of primary immunodeficiency diseases 
    Rossouw, Theresa M.; Theron, Annette J.; Anderson, Ronald (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor and Francis Group, 2018)
    The occurrence of primary immunodeficiency diseases (PIDs) is low compared to that of immune-mediated disorders of autoimmune or atopic origin. However, progress in basic and clinical immunology over the past 3–4 decades ...
  • Precision global health : a roadmap for augmented action 
    Sheat, Danny J.; De Castaneda, Rafael Ruiz.; Bempong, Nefti-Eboni; Raviglione, Mario; Machalaba, Catherine; Pepper, Michael Sean; Vayena, Effy; Ray, Nicolas; Wernli, Didier; Escher, Gerard; Grey, Francois; Elger, Bernice S.; Kleineberg, Kaj-Kolja; Beran, David; Miranda, J. Jaime; Huffman, Mark D.; Hersch, Fred; Andayi, Fred; Thumbi, Samuel M.; D’Acremont, Valerie; Hartley, Mary-Anne; Zinsstag, Jakob; Larus, James; Martínez, María Rodríguez; Guerin, Philippe J.; Merson, Laura; Ngyuen, Vinh-Kim; Rühli, Frank; Geissbuhler, Antoine; Salathé, Marcel; Bolon, Isabelle; Boehme, Catharina; Berkley, Seth; Valleron, Alain-Jacques; Keiser, Olivia; Kaiser, Laurent; Eckerle, Isabella; Utzinger, Jurg; Flahault, Antoine (AME Publishing Company, 2020-03)
    With increased complexity in various global health challenges comes a need for increased precision and the adoption of more tailored health interventions. Building on precision public health, we propose precision global ...
  • Pregnancy outcomes and birth defects from an antiretroviral drug safety study of women in South Africa and Zambia 
    Liu, K. Cherry; Farahani, Mansour; Mashamba, Tshililo; Mawela, Muthuhadini; Joseph, Jessica; Van Schaik, Nienke; Honey, Engela M.; Gill, Michelle; Jassat, Waasila; Stringer, Elizabeth M.; Chintu, Namiwnga; Marlink, Richard G. (Lippincott Williams and Wilkins, 2014-09)
    OBJECTIVE : To evaluate the safety of combination antiretroviral therapy (ART) in conception and pregnancy in different health systems. DESIGN : A pilot ART registry to measure the prevalence of birth defects and ...
  • Prerequisites for establishing a public human UCB SCB; assessment of public acceptance and resistance of UCB to HIV 
    Meissner-Roloff, Madelein (University of Pretoria, 2012)
    South Africa is in dire need of a public umbilical cord blood stem cell bank (UCB SCB). A severe shortage of genetically compatible samples for BM transplantation precludes the majority of South Africans from receiving the ...
  • Prevalence of scientific misconduct among a group of researchers in Nigeria 
    Okonta, Patrick; Rossouw, Theresa M. (Wiley-Blackwell, 2013-12)
    BACKGROUND : There is a dearth of information on the prevalence of scientific misconduct from Nigeria. OBJECTIVES : This study aimed at determining the prevalence of scientific misconduct in a group of researchers in ...
  • The prevalence of smoking and the knowledge of smoking hazards and smoking cessation strategies among HIV-positive patients in Johannesburg, South Africa 
    Maweru, P.; Anderson, Ronald; Steel, Helen C.; Venter, Willem Daniel Francois; Murdoch, D.; Feldman, Charles (Health and Medical Publishing Group, 2013-11)
    BACKGROUND. While the detrimental effects of smoking among HIV-positive patients have been well documented, there is a paucity of data regarding cigarette smoking prevalence among these patients in South Africa ...
  • Primary drug resistance in South Africa : data from 10 years of surveys 
    Manasa, Justen; Katzenstein, David; Cassol, Sharon; Newell, Marie-Louise; De Oliveira, Tulio (Mary Ann Liebert, 2012)
    HIV-1 transmitted drug resistance (TDR) could reverse the gains of antiretroviral rollout. To ensure that current first-line therapies remain effective, TDR levels in recently infected treatment-naive patients need to be ...
  • Primary immunodeficiency in Africa - a review 
    Erjaee, A.; Bagherpour, Morteza; Van Rooyen, Cathy; Van den Berg, Sylvia; Kinnear, C.J.; Green, Robin J.; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    BACKGROUND: Efforts have been made worldwide to improve awareness and treatment of primary immunodeficiency (PID). This has also gained momentum on the African continent albeit at a slower pace. OBJECTIVE: This review ...
  • Priority pharmacogenetics for the African continent : focus on CYP450 
    Alessandrini, Marco; Pepper, Michael Sean (Future Medicine, 2014-02)
    Countries in Africa have a high burden of communicable disease, and are experiencing an increase in non-communicable diseases due to the effects of globalization, industrialization and urbanization. The costs incurred ...
  • Privacy rights of human research participants in South Africa must be taken seriously 
    Staunton, Ciara; Adams, Rachel; Botes, M.; Dove, Edward S.; Horn, Lyn; Labuschaigne, Melodie; Loots, Glaudina; Mahomed, Safia; Olckers, Antonel; Pepper, Michael Sean; Pope, Anne; Ramsay, Michele; Loideain, Nora Ni; De Vries, Jantina (Health and Medical Publishing Group, 2020-03)
    The Protection of Personal Information Act 4 of 2013 (POPIA) was enacted by the South African (SA) parliament in 2013 after a long process of public consultation. To allow all sectors of SA society sufficient time to prepare ...
  • Pro-inflammatory interactions of dolutegravir with human neutrophils in an in vitro study 
    Theron, Annette J.; Anderson, Ronald; Madzime, Morris; Rossouw, Theresa M.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Cholo, Moloko C.; Kwofie, Luyanda Laura Illicia; Feldman, Charles; Tintinger, Gregory (MDPI, 2022-12-19)
    There is increasing awareness of an association between the uptake of the HIV integrase inhibitor, dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development of the metabolic syndrome, ...
  • Pro-tumorigenic and thrombotic activities of platelets in lung cancer 
    Anderson, Ronald; Rapoport, Bernardo Leon; Steel, Helen C.; Theron, Annette J. (MDPI, 2023-07)
    Aside from their key protective roles in hemostasis and innate immunity, platelets are now recognized as having multifaceted, adverse roles in the pathogenesis, progression and outcome of many types of human malignancy. ...
  • Prognostic significance of the neutrophil/lymphocyte ratio in patients undergoing treatment with nivolumab for recurrent non-small-cell lung cancer 
    Rapoport, Bernardo Leon; Theron, Annette J.; Vorobiof, Daniel A.; Langenhoven, Lizanne; Hall, Jacqueline M.; Van Eeden, Ronwyn I.; Smit, Teresa; Chan, Sze-Wai; Botha, Michael C.; Raats, Johann I.; De Necker, Margriet; Anderson, Ronald (MDPI, 2020-06)
    AIM: We investigated the prognostic potential of pretherapy measurement of the neutrophil/lymphocyte ratio (NLR) in patients (n = 56) with non-small-cell lung cancer deemed suitable for treatment with nivolumab. MATERIALS ...