Browsing Immunology by Title

Browsing Immunology by Title

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  • A global comparative overview of the legal regulation of stem cell research and therapy : lessons for South Africa 
    Nothling-Slabbert, Melodie; Pepper, Michael Sean (Health and Medical Publishing Group, 2015-08)
    Stem cell research and its potential translation to regenerative medicine, tissue engineering and cell and gene therapy, have led to controversy and debates similar to the calls nearly 25 years ago for a ban involving ...
  • Glucocorticoids with or without fludrocortisone in septic shock : a narrative review from a biochemical and molecular perspective 
    Nethathe, Gladness D.; Lipman, Jeffrey; Anderson, Ronald; Fuller, Peter J.; Feldman, Charles (Elsevier, 2024-01)
    Two randomised controlled trials have reported a reduction in mortality when adjunctive hydrocortisone is administered in combination with fludrocortisone compared with placebo in septic shock. A third trial did not support ...
  • GnRH antagonists produce differential modulation of the signaling pathways mediated by GnRH receptors 
    Sperduti, Samantha; Limoncella, Silvia; Lazzaretti, Clara; Paradiso, Elia; Riccetti, Laura; Turchi, Sara; Ferrigno, Ilaria; Bertacchini, Jessika; Palumbo, Carla; Potì, Francesco; Longobardi, Salvatore; Millar, Robert P.; Simoni, Manuela; Newton, Claire L.; Casarini, Livio (MDPI Publishing, 2019-11-07)
    Commercial gonadotropin-releasing hormone (GnRH) antagonists di er by 1–2 amino acids and are used to inhibit gonadotropin production during assisted reproduction technologies (ART). In this study, potencies of three ...
  • Guideline for the diagnosis and treatment of chronic pancreatitis 
    Bornman, P.C.; Botha, J.F.; Ramos, J.M.; Smith, M.D.; Van der Merwe, S.; Watermeyer, G.A.; Ziady, C.C.M. (Health and Medical Publishing Group, 2010-12)
    BACKGROUND: Chronic pancreatitis (CP) is defined as a continuing inflammatory disease of the pancreas characterised by irreversible morphological changes, often associated with pain and with the loss of exocrine and/or ...
  • Guidelines for antiretroviral therapy in adults by the Southern African HIV clinicians society 
    Meintjes, Graeme; Maartens, Gary; Boulle, Andrew; Conradie, Francesca; Goemaere, Eric; Hefer, Eric; Johnson, Dave; Mathe, Moeketsi; Moosa, Yunus; Osih, Regina; Rossouw, Theresa M.; Van Cutsem, Gilles; Variava, Ebrahim; Venter, Francois; Spencer, Dave (Health and Medical Publishing Group, 2012-09)
    These guidelines are intended as an update to those published in the Southern African Journal of HIV Medicine in January 2008. Since the release of the previous guidelines, the scaleup of antiretroviral therapy (ART) ...
  • Haematopoietic stem cell transplantation in South Africa : current limitations and future perspectives 
    Grobbelaar, Simone; Mercier, Anne Elisabeth; Verburgh, Estelle; Brittain, David; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. HSCT provides life-changing and potentially curative therapy for a ...
  • Harmful interactions of non-essential heavy metals with cells of the innate immune system 
    Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (2012-04-16)
    In trace amounts, some heavy metals are essential for optimum health, while exposure to others, which are non-essential, presents the potential hazard of acute or chronic organ toxicity. Cadmium, mercury, lead, ...
  • HBV/HIV co-infection : the dynamics of HBV in South African patients with AIDS 
    Mayaphi, Simnikiwe Horatious; Rossouw, Theresa M.; Masemola, Difuro P.; Olorunju, Steve A.S.; Mphahlele, M. Jeffrey; Martin, Desmond J. (Health and Medical Publishing Group, 2012-03)
    OBJECTIVE: As sub-Saharan Africa is highly endemic for hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections, and their co-infection requires special management, we aimed to assess the serological and ...
  • HCV genotype 5 : epidemiology and spread of an uncommon genotype 
    Verbeeck, J.; Peigue-Lafeuille, H.; Ross, R.S.; Abergel, A.; Nevens, Frederik; Van der Merwe, Schalk Willem; Van Ranst, Marc; Henquell, C. (Elsevier, 2008-02)
  • Helicobacter pylori and gastric cancer 
    Fritz, Elongo Lekunze; Van der Merwe, Schalk Willem (Health and Medical Publishing Group, 2009-05)
    Gastric cancer is one of the most common forms of cancer worldwide, with an estimated 930 000 new cases diagnosed each year. It is thought to be more prevalent in men than in women. In South Africa the latest cancer ...
  • Hemangiomas - current therapeutic strategies 
    Mabeta, Peaceful Lucy; Pepper, Michael Sean (UBC Press, 2011-07)
    Hemangiomas are benign neoplasms of the vasculature frequently encountered in children. Several studies have shown that these tumors are characterized by excessive angiogenesis. Although benign, the lesions can present ...
  • Heterogeneity of cell therapy products 
    Wolmarans, Elize; Mellet, Juanita; Ambele, Melvin Anyasi; Durandt, Chrisna; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    Cellular therapy has become a billion-dollar industry and is set to become one of the therapeutic pillars of healthcare in the 21st century. Adult stem cells, which include haematopoietic stem and progenitor cells (HSPCs) ...
  • Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations 
    Ambele, Melvin Anyasi; Pepper, Michael Sean; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus (Wiley, 2019-05)
    BACKGROUND : Oral field cancerization describes a multifocal development process involving many cells at once in response to prolong exposure to carcinogens. This case demonstrated differential p16 expression in different ...
  • High mobility group box 1 in human cancer 
    Rapoport, Bernardo Leon; Steel, Helen C.; Theron, Annette J.; Heyman, Liezl; Smit, Teresa; Ramdas, Yastira; Anderson, Ronald (MDPI, 2020-07)
    High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in maintaining genomic structure and function. ...
  • Histopathology and genotyping in infectious spondylitis of HIV- and HIV+ patients 
    Danaviah, S.; Govender, S.; Cassol, Sharon (Lippincott Williams and Wilkins, 2007-07)
    Approximately 2 million South Africans are HIV/TB coinfected, and many develop skeletal disease. The resurgence of spinal tuberculosis, including atypical forms, is due largely to HIV-associated immune suppression. We ...
  • HIV and haematopoiesis 
    Durandt, Chrisna; Potgieter, J.C.; Mellet, Juanita; Herd, Candice Lee; Khoosal, R.; Nel, Jan Gert; Rossouw, Theresa M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-09)
    Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and ...
  • HIV as a cause of immune activation and immunosenescence 
    Sokoya, T.; Steel, Helen C.; Nieuwoudt, M.; Rossouw, Theresa M. (Hindawi Publishing, 2017)
    Systemic immune activation has emerged as an essential component of the immunopathogenesis of HIV. It not only leads to faster disease progression, but also to accelerated decline of overall immune competence. HIV-associated ...
  • HIV drug resistance levels in adults failing first-line antiretroviral therapy in an urban and a rural setting in South Africa 
    Rossouw, Theresa M.; Nieuwoudt, Martin; Manasa, Justen; Malherbe, Glen Pierre; Lessells, Richard J.; Pillay, Sureshnee; Danaviah, Siva; Mahasha, Phetole; Van Dyk, Gisela; De Oliveira, Tulio (Wiley, 2017-02)
    OBJECTIVES : Urban and rural HIV treatment programmes face different challenges in the long-term management of patients. There are few studies comparing drug resistance profiles in patients accessing treatment through these ...
  • HIV management in practice : South Africa has the largest HIV epidemic in the world and it is therefore imperative that all health 
    Rossouw, Theresa M. (Health and Medical Publishing Group, 2011-05)
    This article briefly reviews the new South African HIV treatment guidelines for adults and adolescents, children and pregnant women. It focuses on the timing of the initiation of antiretroviral treatment and argues for ...
  • HIV-associated bacterial pneumonia 
    Feldman, Charles; Anderson, Ronald (Elsevier, 2013-06)
    NiO/activated carbon (AC) composites were successfully synthesized via a hydrothermal reflux process as an electrode material for carbon monoxide (CO) gas sensor application. The X-ray diffraction (XRD) analysis was used ...