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Browsing Research Articles (Genetics) by UP Author "Reader, Janette"
Now showing items 1-20 of 23
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Van der Watt, Mariette Elizabeth; Reader, Janette; Birkholtz, Lyn-Marie (Frontiers Media S.A., 2022-06-09)Plasmodium parasites have a complex life cycle that includes development in the human host as well as the Anopheles vector. Successful transmission of the parasite between its host and vector therefore requires the ...
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Olivier, Tania; Loots, Leigh; Kok, Michelle; De Villiers, Marianne; Reader, Janette; Birkholtz, Lyn-Marie; Arnott, Gareth E.; De Villiers, Katherine A. (Wiley, 2022-05)Please read abstract in the article.
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Dziwornu, Godwin Akpeko; Coertzen, Dina; Leshabane, Meta Kgaogelo; Korkor, Constance M.; Cloete, Cleavon K.; Njoroge, Mathew; Gibhard, Liezl; Lawrence, Nina; Reader, Janette; Van der Watt, Mariette Elizabeth; Wittlin, Sergio; Birkholtz, Lyn-Marie; Chibale, Kelly (American Chemical Society, 2021-04)A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains at the C2 position, which possess dual asexual blood and sexual stage activities, is presented. Structure–activity ...
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Gibhard, Liezl; Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Birkholtz, Lyn-Marie; Wong, Ho Ning; Batty, Kevin T.; Haynes, Richard K.; Wiesner, Lubbe (MDPI, 2021-12-03)Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside ...
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Leshabane, Meta Kgaogelo; Dziwornu, Godwin Akpeko; Coertzen, Dina; Reader, Janette; Moyo, Phanankosi; Van der Watt, Mariette Elizabeth; Chisanga, Kelly; Nsanzubuhoro, Consolata; Ferger, Richard; Erlank, Erica; Venter, Nelius; Koekemoer, Lizette; Chibale, Kelly; Birkholtz, Lyn-Marie (American Chemical Society, 2021-03)The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are ...
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Niemand, Jandeli; Van Biljon, Riette Andele; Van der Watt, Mariette Elizabeth; Van Heerden, Ashleigh; Reader, Janette; Van Wyk, Roelof Daniel Jacobus; Orchard, Lindsey M.; Chibale, Kelly; Llinas, Manuel; Birkholtz, Lyn-Marie (American Chemical Society, 2021-09)Please read abstract in the article.
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Von Gruning, Hilde; Coradin, Mariel; Mendoza, Mariel R.; Reader, Janette; Sidoli, Simone; Garcia, Benjamin A.; Birkholtz, Lyn-Marie (Elsevier, 2022-03)Histone posttranslational modifications (PTMs) frequently co-occur on the same chromatin domains or even in the same molecule. It is now established that these “histone codes” are the result of cross talk between enzymes ...
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Maharaj, Surina; Ekoka, Elodie; Erlank, Erica; Nardini, Luisa; Reader, Janette; Birkholtz, Lyn-Marie; Koekemoer, Lizette L. (BMC, 2022-03)BACKGROUND : Malaria is a devastating disease, transmitted by female Anopheles mosquitoes infected with Plasmodium parasites. Current insecticide-based strategies exist to control the spread of malaria by targeting vectors. ...
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Coetzee, Nanika; Von Gruning, Hilde; Opperman, Daniel; Van der Watt, Mariette Elizabeth; Reader, Janette; Birkholtz, Lyn-Marie (Nature Publishing Group, 2020-02-11)The epigenome of the malaria parasite, Plasmodium falciparum, is associated with regulation of various essential processes in the parasite including control of proliferation during asexual development as well as control ...
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Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Leshabane, Meta Kgaogelo; Langeveld, Henrico; Cheuka, Peter M.; Dziwornu, Godwin Akpeko; Chibale, Kelly; Birkholtz, Lyn-Marie (Taylor and Francis, 2021)The effectiveness of current antimalarial therapies that cure patients of the pathogenic asexual blood stages is rapidly declining due to the spread of antimalarial drug resistance. This requires the development of novel ...
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Connacher, Jessica I.; Josling, Gabrielle A.; Orchard, Lindsey M.; Reader, Janette; Llinas, Manuel; Birkholtz, Lyn-Marie (BMC, 2021-04)BACKGROUND : The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional ...
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Van Biljon, Riette Andele; Van Wyk, Roelof Daniel Jacobus; Painter, Heather J.; Orchard, Lindsey; Reader, Janette; Niemand, Jandeli; Llinas, Manuel; Birkholtz, Lyn-Marie (BioMed Central, 2019-12)BACKGROUND : Malaria pathogenesis relies on sexual gametocyte forms of the malaria parasite to be transmitted between the infected human and the mosquito host but the molecular mechanisms controlling gametocytogenesis ...
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Van Biljon, Riette Andele; Niemand, Jandeli; Clark, Katherine; Verlinden, Bianca K.; Abrie, Clarissa; Von Gruning, Hilde; Smidt, Werner; Smit, Annel; Reader, Janette; Painter, Heather; Llinas, Manuel; Doerig, Christian; Birkholtz, Lyn-Marie (Nature Publishing Group, 2018-11-08)The life cycle of the malaria parasite Plasmodium falciparum is tightly regulated, oscillating between stages of intense proliferation and quiescence. Cyclic 48-hour asexual replication of Plasmodium is markedly different ...
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Reader, Janette; Van der Watt, Mariette Elizabeth; Taylor, Dale; Le Manach, Claire; Mittal, Nimisha; Ottilie, Sabine; Theron, Anjo; Moyo, Phanankosi; Erlank, Erica; Nardini, Luisa; Venter, Nelius; Lauterbach, Sonja; Bezuidenhout, Belinda; Horatscheck, Andre; Van Heerden, Ashleigh; Spillman, Natalie J.; Cowell, Anne N.; Connacher, Jessica I.; Opperman, Daniel; Orchard, Lindsey M.; Llinas, Manuel; Istvan, Eva S.; Goldberg, Daniel E.; Boyle, Grant A.; Calvo, David; Mancama, Dalu; Coetzer, Theresa L.; Winzeler, Elizabeth A.; Duffy, James; Koekemoer, Lizette L.; Basarab, Gregory; Chibale, Kelly; Birkholtz, Lyn-Marie (Nature Publishing Group, 2021-01)Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic ...
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Moyo, Phanankosi; Shamburger, William; Van der Watt, Mariette Elizabeth; Reader, Janette; De Sousa, Ana Carolina C.; Egan, Timothy J.; Maharaj, Vinesh J.; Bringmann, Gerhard; Birkholtz, Lyn-Marie (Elsevier, 2020-08)The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic asexual and sexual Plasmodium falciparum parasites is of utmost importance to achieve the ambitious goal of malaria elimination. Here, ...
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Cheuka, Peter Mubanga; Centani, Luyanda; Arendse, Lauren B.; Fienberg, Stephen; Wambua, Lynn; Renga, Shoneeze S.; Dziwornu, Godwin Akpeko; Kumar, Malkeet; Lawrence, Nina; Taylor, Dale; Wittlin, Sergio; Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Birkholtz, Lyn-Marie; Chibale, Kelly (American Chemical Society, 2021-01)Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation ...
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Reader, Janette; Opperman, Daniel; Van der Watt, Mariette Elizabeth; Theron, Anjo; Leshabane, Meta Kgaogelo; Da Rocha, Michelle; Turner, Jonathan; Garrabrant, Kathleen; Pina, Ivett; Mills, Catherine; Woster, Patrick M.; Birkholtz, Lyn-Marie (Wiley, 2022-11)Malaria elimination requires multipronged approaches, including the application of antimalarial drugs able to block humanto- mosquito transmission of malaria parasites. The transmissible gametocytes of Plasmodium ...
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Mambwe, Dickson; Korkor, Constance M.; Mabhula, Amanda; Ngqumba, Zama; Cloete, Cleavon; Kumar, Malkeet; Barros, Paula Ladeia; Leshabane, Meta Kgaogelo; Coertzen, Dina; Taylor, Dale; Gibhard, Liezl; Njoroge, Mathew; Lawrence, Nina; Reader, Janette; Moreira, Diogo Rodrigo; Birkholtz, Lyn-Marie; Wittlin, Sergio; Egan, Timothy J.; Chibale, Kelly (American Chemical Society, 2022-12)Please read abstract in the article.
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Wong, Ho Ning; Padin-Irizarry, Vivian; Van der Watt, Mariette Elizabeth; Reader, Janette; Liebenberg, Wilna; Wiesner, Lubbe; Smith, Peter; Eribez, Korina; Winzeler, Elizabeth A.; Kyle, Dennis E.; Birkholtz, Lyn-Marie; Coertzen, Dina; Haynes, Richard K. (Frontiers Media, 2020-01-10)We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives ...
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Abacha, Yabalu Z.; Forkuo, Arnold Donkor; Gbedema, Stephen Y.; Mittal, Nimisha; Ottilie, Sabine; Rocamora, Frances; Winzeler, Elizabeth A.; Van Schalkwyk, Donelly A.; Kelly, John M.; Taylor, Martin C.; Reader, Janette; Birkholtz, Lyn-Marie; Lisgarten, David R.; Cockcroft, Jeremy K.; Lisgarten, John N.; Palmer, Rex A.; Talbert, Rosemary C.; Shnyder, Steven D.; Wright, Colin W. (Frontiers Media, 2022-04)The prospect of eradicating malaria continues to be challenging in the face of increasing parasite resistance to antimalarial drugs so that novel antimalarials active against asexual, sexual, and liver-stage malaria parasites ...
Now showing items 1-20 of 23