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Browsing Research Articles (Physiology) by UP Author "Repsold, Lisa"
Now showing items 1-8 of 8
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Repsold, Lisa; Pool, Roger; Karodia, Mohammed; Tintinger, Gregory Ronald; Becker, Piet J.; Joubert, Anna Margaretha (Wiley, 2021-06)Chronic myeloid leukaemia (CML) is a malignancy of the haematopoietic stem cells. The first line of treatment for CML, especially in developing countries, remains the first-generation tyrosine kinase inhibitor, Imatinib. ...
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Repsold, Lisa; Joubert, Annie M. (Hindawi Publishing Corporation, 2018-01-03)Erythrocytes play an important role in oxygen and carbon dioxide transport. Although erythrocytes possess no nucleus or mitochondria, they fulfil severalmetabolic activities namely, the Embden-Meyerhof pathway, as well ...
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Repsold, Lisa; Pretorius, Etheresia; Joubert, Annie M. (BioMed Central, 2014-06-07)BACKGROUND: 2-Methoxyestradiol is known to have antitumour and antiproliferative action in vitro and in vivo. However, when 2-methoxyestradiol is orally administered, it is rapidly oxidized by the enzyme 17β-hydroxyster ...
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Repsold, Lisa; Pretorius, Etheresia; Joubert, Annie M. (BioMed Central, 2016-07-15)BACKGROUND : Platelets are known contributors to the vascularization, metastasis and growth of tumors. Upon their interaction with cancer cells they are activated resulting in degranulation and release of constituents. ...
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Repsold, Lisa; Pretorius, Etheresia; Joubert, Annie M. (Cambridge University Press, 2015-12)Angiogenesis is a closely controlled biological process that takes place during fetal development of blood vessels and wound healing, and includes the development of new blood vessels from preexisting blood vessels. Tumor ...
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Repsold, Lisa; Pool, Roger; Karodia, Mohammed; Tintinger, Gregory Ronald; Joubert, Anna Margaretha (Wiley, 2022-06)Chronic myeloid leukemia (CML) is a myeloproliferative disease and the first line treatment is through the administration of Imatinib, a first generation tyrosine kinase inhibitor. Thrombocytosis and bleeding irregularities ...
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Repsold, Lisa; Pool, Roger; Karodia, Mohammed; Tintinger, Gregory Ronald; Joubert, Annie M. (BioMed Central, 2017-10-10)Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related ...
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Repsold, Lisa; Mqoco, T.V. (Thandi Vuyelwa); Wolmarans, Elize; Nkandeu, Sandra; Theron, Joji; Piorkowski, Tomek; Du Toit, Peet J.; Van Papendorp, D.H. (Dirk Hermanus), 1949-; Joubert, Annie M. (BioMed Central, 2014-09)BACKGROUND : Novel, in silico-designed anticancer compounds were synthesized in our laboratory namely, 2-ethyl-3-Osulphamoyl- estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) and 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene ...
Now showing items 1-8 of 8