Botes, Mandie; Jurgens, Tamarin; Riahi, Zohreh; Visagie, M.H. (Michelle Helen); Janse van Vuuren, Rustelle; Joubert, Annie M.; Van den Bout, Jan Iman(BioMed Central, 2018-11-19)
BACKGROUND : 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties
in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical application. ...
Janse van Vuuren, Rustelle; Botes, Mandie; Jurgens, Tamarin; Joubert, Annie M.; Van den Bout, Jan Iman(BioMed Central, 2019-01-03)
BACKGROUND : The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have
been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis. In ...
