Browsing Research Articles (Physiology) by Subject "Hemangioma"

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Inhibition of hemangioma development in a syngeneic mouse model correlates with bcl-2 suppression and the inhibition of Akt kinase activity

Mabeta, Peaceful Lucy; Pepper, Michael Sean (Springer, 2012-03)

BACKGROUND: Hemangiomas are benign vascular tumors that are characterised by excessive angiogenesis. While there is no definitive treatment for these tumors, several angiogenesis inhibitors, including bleomycin, have ...
Oncosuppressors and oncogenes : role in haemangioma genesis and potential for therapeutic targeting

Mabeta, Peaceful Lucy (MDPI, 2018-04)

Genetic lesions in proto-oncogenes result in the perturbation of angiogenesis, the formation of neovessels from a pre-existing microvasculature. Similarly, the subversion of tumor suppressor genes promotes tumor vascularization. ...
Sunitinib malate inhibits hemangioma cell growth and migration by suppressing focal adhesion kinase signaling

Scholtz, Wihan; Mabeta, Peaceful Lucy (University of South Bohemia in České Budějovice, 2020-12-07)

Sunitinib malate is a small molecule that targets multiple receptor tyrosine kinases and blocks their activity. Receptors targeted by sunitinib are implicated in tumor vascularization and are overexpressed by vascular ...

Now showing items 1-3 of 3

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