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Browsing Research Articles (Physiology) by Subject "Dichloroacetate (DCA)"

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Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways

Stander, Xiao Xing; Stander, Barend Andre; Joubert, Annie M. (Karger, 2015-04)

BACKGROUND : C9, a newly in silico-designed inhibitor of microtubule dynamics induces G2/M arrest culminating in apoptosis. Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase, an enzyme that promotes pyruvate ...

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