Browsing Research Articles (Physiology) by Author "Van der Westhuizen, Carl Johan"

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Binding pose analysis of hydroxyethylamine based β-secretase inhibitors and application thereof to the design and synthesis of novel indeno[1,2-b]indole based inhibitors

Van der Westhuizen, Carl Johan; Van Greunen, D.G. (Divan); Cordier, Werner; Nell, Margo Judith; Steenkamp, Vanessa; Stander, Andre; Panayides, Jenny-Lee; Riley, Darren L. (ARKAT, 2020-04)

β-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer’s disease, and transition-state isosteres such as hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors. A computational ...
A cytotoxic bis(1,2,3-triazol-5-ylidene)carbazolide gold(III) complex targets DNA by partial intercalation

Van der Westhuizen, Danielle; Slabber, Cathryn A.; Fernandes, Manuel A.; Joubert, Daniel Francois; Kleinhans, George; Van der Westhuizen, Carl Johan; Stander, Andre; Munro, Orde; Bezuidenhout, Daniela Ina (Wiley, 2021-06)

The syntheses of bis(triazolium)carbazole precursors and their corresponding coinage metal (Au, Ag) complexes are reported. For alkylated triazolium salts, di- or tetranuclear complexes with bridging ligands were isolated, ...

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