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Browsing Research Articles (Physiology) by Author "Mabeta, Peaceful Lucy"
Now showing items 1-10 of 10
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Mabeta, Peaceful Lucy; Pepper, Michael Sean (Elsevier, 2015-02)Herein, we describe the effects of Taxol on endothelioma cell growth and migration in vitro and on vascular tumor growth in vivo. The effects of Taxol on endothelioma cell growth were determined using the crystal violet ...
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Forcados, Gilead Ebiegberi; James, Dorcas Bolanle; Scoltz, Wihan; Mabeta, Peaceful Lucy (Springer, 2021-06)Vitex doniana leaves are used in traditional medicine systems for the treatment of inflammatory-related disorders and breast cancer in West Africa. However, there is a dearth of scientific evidence on the effectiveness of ...
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Mabeta, Peaceful Lucy; Pepper, Michael Sean (Springer, 2012-03)BACKGROUND: Hemangiomas are benign vascular tumors that are characterised by excessive angiogenesis. While there is no definitive treatment for these tumors, several angiogenesis inhibitors, including bleomycin, have ...
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Mabeta, Peaceful Lucy; Pavic, Kristina; Zorc, Branka (De Gruyter Open, 2018-09)In our previous paper, we showed that three primaquine-cinnamic acid conjugates composed of primaquine (PQ) residue and cinnamic acid derivatives (CADs) bound directly by an amide linkage (1) or through an acylsemicarbazide ...
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Helena, Jolene Michelle; Joubert, Anna Margaretha; Mabeta, Peaceful Lucy; Coetzee, Magdalena; Lakier, Roy; Mercier, Anne Elisabeth (MDPI, 2021-08-17)2-Ethyl-3-O-sulfamoyl-estra-1,3,5(10)16-tetraene (ESE-16) is an in silico-designed estradiol analogue which has improved the parent compound’s efficacy in anti-cancer studies. In this proofof- concept study, the potential ...
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Mabeta, Peaceful Lucy; Hull, Rodney; Dlamini, Zodwa (MDPI, 2022-01-15)Angiogenesis is one of the hallmarks of cancer, and the establishment of new blood vessels is vital to allow for a tumour to grow beyond 1–2 mm in size. The angiogenic switch is the term given to the point where the ...
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Oncosuppressors and oncogenes : role in haemangioma genesis and potential for therapeutic targeting Mabeta, Peaceful Lucy (MDPI, 2018-04)Genetic lesions in proto-oncogenes result in the perturbation of angiogenesis, the formation of neovessels from a pre-existing microvasculature. Similarly, the subversion of tumor suppressor genes promotes tumor vascularization. ...
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Mabeta, Peaceful Lucy (Elsevier, 2020-07)Melanoma is the most aggressive form of skin cancer. Malignant melanoma in particular has a poor prognosis and although treatment has improved, drug resistance continues to be a challenge. Angiogenesis, the formation of ...
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Scholtz, Wihan; Mabeta, Peaceful Lucy (University of South Bohemia in České Budějovice, 2020-12-07)Sunitinib malate is a small molecule that targets multiple receptor tyrosine kinases and blocks their activity. Receptors targeted by sunitinib are implicated in tumor vascularization and are overexpressed by vascular ...
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Mabeta, Peaceful Lucy; Steenkamp, Vanessa (MDPI, 2022-12)The vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor (VEGFR) axis is indispensable in the process of angiogenesis and has been implicated as a key driver of tumor vascularization. ...
Now showing items 1-10 of 10