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Browsing Research Articles (Medical Microbiology) by Subject "Canonical variant"

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Emergence of canonical and non-canonical genomic variants following in vitro exposure of clinical Mycobacterium tuberculosis strains to bedaquiline or clofazimine

Ismail, Nazir Ahmed; Dippenaar, Anzaan; Warren, R.M.; Peters, Remco P.H.; Omar, Shaheed V. (American Society for Microbiology, 2023-04)

In Mycobacterium tuberculosis, bedaquiline and clofazimine resistance occurs primarily through Rv0678 variants, a gene encoding a repressor protein that regulates mmpS5/mmpL5 efflux pump gene expression. Despite the shared ...

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