Browsing Research Articles (Medical Microbiology) by Author "Niemann, Stefan"

Browsing Research Articles (Medical Microbiology) by Author "Niemann, Stefan"

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  • Drug-resistance mechanisms and tuberculosis drugs 
    Ismail, Nazir Ahmed; Koser, Claudio U.; Javid, Babak; Ellington, Matthew J.; Feveriegel, Silke; Niemann, Stefan; Brown, Nicolas M.; Burman, William J.; Abubakar, Ibrahim; Moore, David; Peacock, Sharon J.; Torok, M.Estee; Liddel, Kathleen (Elsevier, 2015-01)
    Bedaquiline and delamanid, novel classes of anti-tuberculosis drugs, have been recently approved for the treatment of multidrug-resistant tuberculosis. Antimicrobial resistance invariably follows the introduction of ...
  • Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study 
    Zignol, Matteo; Cabibbe, Andrea Maurizio; Dean, Anna S.; Glaziou, Philippe; Alikhanova, Natavan; Ama, Cecilia; Andres, Sonke; Barbova, Anna; Borbe-Reyes, Angeli; Chin, Daniel P.; Cirillo, Daniela Maria; Colvin, Charlotte; Dadu, Andrei; Dreyer, Andries; Driesen, Michele; Gilpin, Christopher; Hasan, Rumina; Hasan, Zahra; Hoffner, Sven; Hussain, Alamdar; Ismail, Nazir Ahmed; Kamal, S.M. Mostofa; Khanzada, Faisal Masood; Kimerling, Michael; Kohl, Thomas Andreas; Mansjo, Mikael; Miotto, Paolo; Mukadi, Ya Diul; Mvusi, Lindiwe; Niemann, Stefan; Omar, Shaheed Vally; Rigouts, Leen; Schito, Marco; Sela, Ivita; Seyfaddinova, Mehriban; Skenders, Girts; Skrahina, Alena; Tahseen, Sabira; Wells, William A.; Zhurilo, Alexander; Weyer, Karin; Floyd, Katherine; Raviglione, Mario C. (Elsevier, 2018-06)
    BACKGROUND : In many countries, regular monitoring of the emergence of resistance to anti-tuberculosis drugs is hampered by the limitations of phenotypic testing for drug susceptibility. We therefore evaluated the use ...
  • MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era 
    Beckert, Patrick; Sanchez-Padilla, Elisabeth; Merker, Matthias; Dreyer, Viola; Kohl, Thomas A.; Utpatel, Christian; Köser, Claudio U.; Barilar, Ivan; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Klopper, Marisa; Warren, Robin M.; Hoffmann, Harald; Maphalala, Gugu; Ardizzoni, Elisa; De Jong, Bouke C.; Kerschberger, Bernhard; Schramm, Birgit; Andres, Sonke; Kranzer, Katharina; Maurer, Florian P.; Bonnet, Maryline; Niemann, Stefan (BioMed Central, 2020-12)
    BACKGROUND: Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening ...
  • Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones : results from a multicountry surveillance project 
    Zignol, Matteo; Dean, Anna S.; Alikhanova, Natavan; Andres, Sonke; Cabibbe, Andrea Maurizio; Cirillo, Daniela Maria; Dadu, Andrei; Dreyer, Andries; Driesen, Michèle; Gilpin, Christopher; Hasan, Rumina; Hasan, Zahra; Hoffner, Sven; Husain, Ashaque; Hussain, Alamdar; Ismail, Nazir Ahmed; Kamal, Mostofa; Mansjo, Mikael; Mvusi, Lindiwe; Niemann, Stefan; Omar, Shaheed Vally; Qadeer, Ejaz; Rigouts, Leen; Ruesch-Gerdes, Sabine; Schito, Marco; Seyfaddinova, Mehriban; Skrahina, Alena; Tahseen, Sabira; Wells, William A.; Mukadi, Ya Diul; Kimerling, Michael; Floyd, Katherine; Weyer, Karin; Raviglione, Mario C. (Elsevier, 2016-10)
    BACKGROUND : Pyrazinamide and fluoroquinolones are essential antituberculosis drugs in new rifampicin-sparing regimens. However, little information about the extent of resistance to these drugs at the population level is ...
  • Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis 
    Bradley, Phelim; Gordon, N. Claire; Walker, Timothy M.; Dunn, Laura; Heys, Simon; Huang, Bill; Earle, Sarah; Pankhurst, Louise J.; Anson, Luke; De Cesare, Mariateresa; Piazza, Paolo; Votintseva, Antonina A.; Golubchik, Tanya; Wilson, Daniel J.; Wyllie, David H.; Diel, Ronald; Niemann, Stefan; Feuerriegel, Silke; Kohl, Thomas A.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Smith, E. Grace; Buck, David; McVean, Gil; Walker, A. Sarah; Peto, Tim E.A.; Crook, Derrick W.; Iqbal, Zamin (Nature Publishing Group, 2015-12-21)
    The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug resistance in clinical samples, and improvements in global surveillance. Here we show how de Bruijn graph representation of ...
  • Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance : a retrospective cohort study 
    Ismail, Nazir Ahmed; Omar, Shaheed Vally; Walker, Timothy M.; Kohl, Thomas A.; Hedge, Jessica; Elias, Carlos Del Ojo; Bradley, Phelim; Iqbal, Zamin; Feuerriegel, Silke; Niehaus, Katherine E.; Wilson, Daniel J.; Clifton, David A.; Kapatai, Georgia; Ip, Camilla L.C.; Bowden, Rory; Drobniewski, Francis A.; Allix-Béguec, Caroline; Gaudin, Cyril; Parkhill, Julian; Diel, Roland; Supply, Philip; Crook, Derrick W.; Smith, E. Grace; Walker, A. Sarah; Niemann, Stefan; Peto, Tim E. A.; Davies, J.; Crichton, C.; Acharya, M.; Madrid-Marquez, Eyre, D.; Wyllie, D.; Golubchik, T.; Munang, M. (Elsevier, 2015-10)
    BACKGROUND : Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis. Phenotypic drugsusceptibility testing is slow and expensive, and commercial genotypic assays screen only common resistanced ...