dc.contributor.author |
Birkholtz, Lyn-Marie
|
|
dc.contributor.author |
Williams, Marni
|
|
dc.contributor.author |
Niemand, Jandeli
|
|
dc.contributor.author |
Louw, Abraham Izak
|
|
dc.contributor.author |
Persson, Lo
|
|
dc.contributor.author |
Heby, Olle
|
|
dc.date.accessioned |
2011-10-11T07:10:36Z |
|
dc.date.available |
2011-10-11T07:10:36Z |
|
dc.date.issued |
2011-04-21 |
|
dc.description.abstract |
New drugs are urgently needed for the treatment of tropical
and subtropical parasitic diseases, such as African sleeping
sickness, Chagas’ disease, leishmaniasis and malaria. Enzymes
in polyamine biosynthesis and thiol metabolism, as well as
polyamine transporters, are potential drug targets within these
organisms. In the present review, the current knowledge of unique
properties of polyamine metabolism in these parasites is outlined.
These properties include prozyme regulation of AdoMetDC (Sadenosylmethionine
decarboxylase) activity in trypanosomatids,
co-expression of ODC (ornithine decarboxylase) and AdoMetDC
activities in a single protein in plasmodia, and formation of
trypanothione, a unique compound linking polyamine and thiol
metabolism in trypanosomatids. Particularly interesting features
within polyamine metabolism in these parasites are highlighted
for their potential in selective therapeutic strategies. |
en |
dc.description.sponsorship |
This work was supported by a collaborative research exchange grant between the South
African National Research Foundation (NRF) and the Swedish International Development
Cooperation Agency (SIDA, Swedish Research Links Programme). J.N., M.W., A.I.L.
and L.B. are members of the South African Malaria Initiative (http://www.sami.org.za ) .
Support was also obtained from the European Cooperation on Science and Technology
[grant number COST-CM0801] (to L.P. and O.H.) and the Royal Physiographic Society in
Lund (to O.H.). |
en_US |
dc.description.uri |
http://www.biochemj.org/bj/default.htm |
en_US |
dc.identifier.citation |
Birkholtz, LM, Williams, M, Niemand, J, Louw, AI, Persson, L, & Heby, O 2011, 'Polyamine homoeostasis as a drug target in pathogenic protozoa : peculiarities and possibilities', Biochemical Journal, vol. 438, no. 2, pp. 229-244. |
en |
dc.identifier.issn |
0264-6021 (print) |
|
dc.identifier.issn |
1470-8728 (online) |
|
dc.identifier.other |
10.1042/BJ20110362 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/17421 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Portland Press on behalf of the Biochemical Society |
en_US |
dc.rights |
© 2011 The Author(s). The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence. |
en |
dc.subject |
α-difluoromethylornithine |
en |
dc.subject |
S-adenosylmethionine decarboxylase (AdoMetDC) |
en |
dc.subject |
Spermidine synthase |
en |
dc.subject.lcsh |
Leishmania -- Treatment |
en |
dc.subject.lcsh |
Malaria -- Treatment |
en |
dc.subject.lcsh |
African trypanosomiasis -- Treatment |
en |
dc.subject.lcsh |
Chagas' disease -- Treatment |
en |
dc.subject.lcsh |
Trypanosoma |
en |
dc.subject.lcsh |
Ornithine decarboxylase |
en |
dc.subject.lcsh |
Polyamines |
en |
dc.subject.lcsh |
Adenosylmethionine |
en |
dc.subject.lcsh |
Protozoa, Pathogenic |
en |
dc.title |
Polyamine homoeostasis as a drug target in pathogenic protozoa : peculiarities and possibilities |
en |
dc.type |
Article |
en |