Browsing Research Articles (Microbiology and Plant Pathology) by Author "Orchard, Lindsey M."

Browsing Research Articles (Microbiology and Plant Pathology) by Author "Orchard, Lindsey M."

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  • Chemogenomic fingerprints associated with stage-specific gametocytocidal compound action against human malaria parasites 
    Niemand, Jandeli; Van Biljon, Riette Andele; Van der Watt, Mariette Elizabeth; Van Heerden, Ashleigh; Reader, Janette; Van Wyk, Roelof Daniel Jacobus; Orchard, Lindsey M.; Chibale, Kelly; Llinas, Manuel; Birkholtz, Lyn-Marie (American Chemical Society, 2021-09)
    Please read abstract in the article.
  • H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum 
    Connacher, Jessica I.; Josling, Gabrielle A.; Orchard, Lindsey M.; Reader, Janette; Llinas, Manuel; Birkholtz, Lyn-Marie (BMC, 2021-04)
    BACKGROUND : The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional ...
  • Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box 
    Reader, Janette; Van der Watt, Mariette Elizabeth; Taylor, Dale; Le Manach, Claire; Mittal, Nimisha; Ottilie, Sabine; Theron, Anjo; Moyo, Phanankosi; Erlank, Erica; Nardini, Luisa; Venter, Nelius; Lauterbach, Sonja; Bezuidenhout, Belinda; Horatscheck, Andre; Van Heerden, Ashleigh; Spillman, Natalie J.; Cowell, Anne N.; Connacher, Jessica I.; Opperman, Daniel; Orchard, Lindsey M.; Llinas, Manuel; Istvan, Eva S.; Goldberg, Daniel E.; Boyle, Grant A.; Calvo, David; Mancama, Dalu; Coetzer, Theresa L.; Winzeler, Elizabeth A.; Duffy, James; Koekemoer, Lizette L.; Basarab, Gregory; Chibale, Kelly; Birkholtz, Lyn-Marie (Nature Publishing Group, 2021-01)
    Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic ...