• Cultivated hawthorn (Crataegus pinnatifida var. major) genome sheds light on the evolution of Maleae (apple tribe) 

  Zhang, Ticao; Qiao, Qin; Du, Xiao; Zhang, Xiao; Hou, Yali; Wei, Xin; Sun, Chao; Zhang, Rengang; Yun, Quanzheng; Crabbe, M. James C.; Van de Peer, Yves; Dong, Wenxuan (Wiley, 2022-08)

  Cultivated hawthorn (Crataegus pinnatifida var. major) is an important medicinal and edible plant with a long history of use for health protection in China. Herein, we provide a de novo chromosomelevel genome sequence ...
• The neighborhood of the spike gene Is a hotspot for modular intertypic homologous and nonhomologous recombination in coronavirus genomes 

  Nikolaidis, Marios; Markoulatos, Panayotis; Van de Peer, Yves; Oliver, Stephen G.; Amoutzias, Grigorios D. (Oxford University Press, 2022-01)

  Coronaviruses (CoVs) have very large RNA viral genomes with a distinct genomic architecture of core and accessory open reading frames (ORFs). It is of utmost importance to understand their patterns and limits of homologous ...
• Evolution of isoform-level gene expression patterns across tissues during lotus species divergence 

  Zhang, Yue; Yang, Xingyu; Van de Peer, Yves; Chen, Jinming; Marchal, Kathleen; Shi, Tao (Wiley, 2022-11)

  Both gene duplication and alternative splicing (AS) drive the functional diversity of gene products in plants, yet the relative contributions of the two key mechanisms to the evolution of gene function are largely unclear. ...
• In vitro dual activity of Aloe marlothii roots and its chemical constituents against Plasmodium falciparum asexual and sexual stage parasites 

  Mianda, S.M.; Invernizzi, Luke; Van der Watt, Mariette Elizabeth; Reader, Janette; Moyo, Phanankosi; Birkholtz, Lyn-Marie; Maharaj, Vinesh J. (Elsevier, 2022-10)

  Please abstract in the article.
• New transmission-selective antimalarial agents through hit-to-lead optimization of 2-([1,1 '-Biphenyl]-4-carboxamido)benzoic acid derivatives 

  Reader, Janette; Opperman, Daniel; Van der Watt, Mariette Elizabeth; Theron, Anjo; Leshabane, Meta Kgaogelo; Da Rocha, Michelle; Turner, Jonathan; Garrabrant, Kathleen; Pina, Ivett; Mills, Catherine; Woster, Patrick M.; Birkholtz, Lyn-Marie (Wiley, 2022-11)

  Malaria elimination requires multipronged approaches, including the application of antimalarial drugs able to block humanto- mosquito transmission of malaria parasites. The transmissible gametocytes of Plasmodium ...
• syntenet : an R/Bioconductor package for the inference and analysis of synteny networks 

  Almeida-Silva, Fabricio; Zhao, Tao; Ullrich, Kristian K.; Schranz, M. Eric; Van de Peer, Yves (Oxford University Press, 2023-01)

  Interpreting and visualizing synteny relationships across several genomes is a challenging task. We previously proposed a network-based approach for better visualization and interpretation of large-scale microsynteny ...
• By blood or by choice? On relational autonomy and the familial ties that bind us 

  Van Wyk, Tanya (Stellenbosch University, Faculty of Theology, 2022)

  This article explores the range of the construct “family” in light of the author’s experience of how the death of a congregation-member exposed the strength, persistence and immovability of the construct, “family”. Despite ...
• Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model 

  Mambwe, Dickson; Korkor, Constance M.; Mabhula, Amanda; Ngqumba, Zama; Cloete, Cleavon; Kumar, Malkeet; Barros, Paula Ladeia; Leshabane, Meta Kgaogelo; Coertzen, Dina; Taylor, Dale; Gibhard, Liezl; Njoroge, Mathew; Lawrence, Nina; Reader, Janette; Moreira, Diogo Rodrigo; Birkholtz, Lyn-Marie; Wittlin, Sergio; Egan, Timothy J.; Chibale, Kelly (American Chemical Society, 2022-12)

  Please read abstract in the article.
• Population genetics of a lethally managed medium-sized predator 

  Slater, K.; De Jager, Deon; Van Wyk, A.M.; Dalton, Desire Lee; Kropff, Anna S.; Du Preez, Ilse (Wiley, 2022-09)

  Globally, levels of human–wildlife conflict are increasing as a direct consequence of the expansion of people into natural areas resulting in competition with wildlife for food and other resources. By being forced into ...
• The genome of homosporous maidenhair fern sheds light on the euphyllophyte evolution and defences 

  Fang, Yuhan; Qin, Xing; Liao, Qinggang; Du, Ran; Luo, Xizhi; Zhou, Qian; Li, Zhen; Chen, Hengchi; Jin, Wanting; Yuan, Yaning; Sun, Pengbo; Zhang, Rui; Zhang, Jiao; Wang, Li; Cheng, Shifeng; Yang, Xueyong; Yan, Yuehong; Zhang, Xingtan; Zhang, Zhonghua; Bai, Shunong; Van de Peer, Yves; Lucas, William John; Huang, Sanwen; Yan, Jianbin (Nature Research, 2022-09)

  Euphyllophytes encompass almost all extant plants, including two sister clades, ferns and seed plants. Decoding genomes of ferns is the key to deep insight into the origin of euphyllophytes and the evolution of seed plants. ...
• Chromosome-scale assembly of the Moringa oleifera Lam. genome uncovers polyploid history and evolution of secondary metabolism pathways through tandem duplication 

  Chang, Jiyang; Marczuk-Rojas, Juan Pablo; Waterman, Carrie; Garcia-Llanos, Armando; Chen, Shiyu; Ma, Xiao; Hulse-Kemp, Amanda; Van Deynze, Allen; Van de Peer, Yves; Carretero-Paulet, Lorenzo (Wiley Open Access, 2022-09)

  The African Orphan Crops Consortium (AOCC) selected the highly nutritious, fast growing and drought tolerant tree crop moringa (Moringa oleifera Lam.) as one of the first of 101 plant species to have its genome sequenced ...
• Evolutionary history and pan-genome dynamics of strawberry (Fragaria spp.) 

  Qiao, Qin; Edger, Patrick P.; Xue, Li; Qiong, La; Lu, Jie; Zhang, Yichen; Cao, Qiang; Yocca, Alan E.; Platts, Adrian E.; Knapp, Steven J.; Van Montagu, Marc; Van de Peer, Yves; Lei, Jiajun; Zhang, Ticao (National Academy of Sciences, 2021-10)

  Strawberry (Fragaria spp.) has emerged as a model system for various fundamental and applied research in recent years. In total, the genomes of five different species have been sequenced over the past 10 y. Here, we report ...
• Endemic persistence of a highly contagious pathogen : foot-and-mouth disease in its wildlife host 

  Jolles, Anna; Gorsich, Erin; Gubbins, Simon; Beechler, Brianna; Buss, Peter Erik; Juleff, Nick; De Klerk-Lorist, Lin-Mari; Maree, Francois Frederick; Perez-Martin, Eva; Van Schalkwyk, Ockert Louis; Scott, Katherine; Zhang, Fuquan; Medlock, Jan; Charleston, Bryan (American Association for the Advancement of Science, 2021-09)

  Extremely contagious pathogens are a global biosecurity threat because of their high burden of morbidity and mortality, as well as their capacity for fast-moving epidemics that are difficult to quell. Understanding the ...
• The genome of hibiscus hamabo reveals its adaptation to saline and waterlogged habitat 

  Wang, Zhiquan; Xue, Jia-Yu; Hu, Shuai-Ya; Zhang, Fengjiao; Yu, Ranran; Chen, Dijun; Van de Peer, Yves; Jiang, Jiafu; Song, Aiping; Ni, Longjie; Hua, Jianfeng; Lu, Zhiguo; Yu, Chaoguang; Yin, Yunlong; Gu, Chunsun (Oxford University Press, 2022-03-23)

  Hibiscus hamabo is a semi-mangrove species with strong tolerance to salt and waterlogging stress. However, the molecular basis and mechanisms that underlie this strong adaptability to harsh environments remain poorly ...
• MicroRNA-mediated post-transcriptional regulation of Pinus pinaster response and resistance to pinewood nematode 

  Modesto, Ines; Inacio, Vera; Van de Peer, Yves; Miguel, Celia (Nature Research, 2022-03-25)

  Pine wilt disease (PWD), caused by the parasitic nematode Bursaphelenchus xylophilus, or pinewood nematode (PWN), is a serious threat to pine forests in Europe. Pinus pinaster is highly susceptible to the disease and it ...
• Adapt or die : targeting unique transmission-stage biology for malaria elimination 

  Van der Watt, Mariette Elizabeth; Reader, Janette; Birkholtz, Lyn-Marie (Frontiers Media S.A., 2022-06-09)

  Plasmodium parasites have a complex life cycle that includes development in the human host as well as the Anopheles vector. Successful transmission of the parasite between its host and vector therefore requires the ...
• SNP detection in Pinus pinaster transcriptome and association with resistance to pinewood nematode 

  Modesto, Ines; Inacio, Vera; Novikova, Polina; Carrasquinho, Isabel; Van de Peer, Yves; Miguel, Celia (MDPI, 2022-06-17)

  Pinewood nematode (PWN, Bursaphelenchus xylophilus) is the causal agent of pine wilt disease (PWD), which severely affects Pinus pinaster stands in southwestern Europe. Despite the high susceptibility of P. pinaster, ...
• Genomic and metabolomic analyses of the marine fungus Emericellopsis cladophorae: insights into saltwater adaptability mechanisms and its biosynthetic potential 

  Goncalves, Micael; Hilario, Sandra; Van de Peer, Yves; Esteves, Ana; Alves, Artur (MDPI, 2022-01)

  The genus Emericellopsis is found in terrestrial, but mainly in marine, environments with a worldwide distribution. Although Emericellopsis has been recognized as an important source of bioactive compounds, the range of ...
• The artemiside-artemisox-artemisone-m1 tetrad : efficacies against blood stage p. falciparum parasites, dmpk properties, and the case for artemiside 

  Gibhard, Liezl; Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Birkholtz, Lyn-Marie; Wong, Ho Ning; Batty, Kevin T.; Haynes, Richard K.; Wiesner, Lubbe (MDPI, 2021-12-03)

  Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside ...
• Genome-wide analysis of butterfly bush (Buddleja alternifolia) in three uplands provides insights into biogeography, demography and speciation 

  Ma, Yong-Peng; Liao, Rong-Li; Zhang, Ren-Gang; Yun, Quan-Zheng; Olmstead, Richard G.; Chau, John H.; Milne, Richard I.; Van de Peer, Yves; Sun, Wei-Bang (Wiley, 2021-11)

  Understanding processes that generate and maintain large disjunctions within plant species can provide valuable insights into plant diversity and speciation. The butterfly bush Buddleja alternifolia has an unusual disjunct ...

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