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Browsing Research Articles (Biochemistry) by UP Author "Verlinden, Bianca K."
Now showing items 1-5 of 5
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Niemand, Jandeli; Burger, Pieter Buys; Verlinden, Bianca K.; Reader, Janette; Joubert, Annie M.; Kaiser, Annette; Louw, Abraham Izak; Kirk, Kiaran; Phanstiel IV, Otto; Birkholtz, Lyn-Marie (American Society for Microbiology, 2013-06)Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in the nM-μM range. The compounds are taken up into the ...
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Verlinden, Bianca K.; Niemand, Jandeli; Snyman, Janette; Sharma, Shirv K.; Beattie, Ross J.; Woster, Partick M.; Birkholtz, Lyn-Marie (American Chemical Society, 2011-10)A series of alkylated (bis)urea and (bis)thiourea polyamine analogues were synthesized and screened for antimalarial activity against chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. All ...
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Van Biljon, Riette Andele; Niemand, Jandeli; Clark, Katherine; Verlinden, Bianca K.; Abrie, Clarissa; Von Gruning, Hilde; Smidt, Werner; Smit, Annel; Reader, Janette; Painter, Heather; Llinas, Manuel; Doerig, Christian; Birkholtz, Lyn-Marie (Nature Publishing Group, 2018-11-08)The life cycle of the malaria parasite Plasmodium falciparum is tightly regulated, oscillating between stages of intense proliferation and quiescence. Cyclic 48-hour asexual replication of Plasmodium is markedly different ...
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Verlinden, Bianca K.; De Beer, Marna; Pachaiyappan, Boobalan; Besaans, Ethan Wade; Anday, Warren A.; Reader, Janette; Niemand, Jandeli; Van Biljon, Riette Andele; Guy, Kiplin; Egan, Timothy; Woster, Patrick M.; Birkholtz, Lyn-Marie (Elsevier, 2015-08)A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated in vitro for their antiplasmodial activity. Altering the carbon backbone and terminal substituents ...
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Verlinden, Bianca K.; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Taylor and Francis, 2016-02)INTRODUCTION : Currently, widely used antimalarial drugs have a limited clinical lifespan due to parasite resistance development. With resistance continuously rising, antimalarial drug discovery requires strategies to ...
Now showing items 1-5 of 5