Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites
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Date
Authors
Niemand, Jandeli
Burger, Pieter Buys
Verlinden, Bianca K.
Reader, Janette
Joubert, Annie M.
Kaiser, Annette
Louw, Abraham Izak
Kirk, Kiaran
Phanstiel IV, Otto
Birkholtz, Lyn-Marie
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract
Anthracene-polyamine conjugates inhibit the in vitro proliferation of the
intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in
the nM-μM range. The compounds are taken up into the intraerythrocytic parasite
where they arrest the parasite cell-cycle. Both the anthracene and polyamine
components of the conjugates play a role in their antiplasmodial effect.
Description
Keywords
Malaria, Plasmodium falciparum, Spermidine, Putrescine, Anthracene
Sustainable Development Goals
Citation
Niemand, J, Burger, P, Verlinden, BK, Reader, J, Joubert, AM, Kaiser, A, Louw, AI, Kirk, K, Phanstiel IV, O & Birkholtz, LM 2013, 'Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites', Antimicrobial Agents and Chemotherapy, vol. 57, no. 6, pp. 2874-2877.