Anthracene-polyamine conjugates inhibit the in vitro proliferation of the
intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in
the nM-μM range. The compounds are taken up into the intraerythrocytic parasite
where they arrest the parasite cell-cycle. Both the anthracene and polyamine
components of the conjugates play a role in their antiplasmodial effect.
