Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites

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Authors

Niemand, Jandeli
Burger, Pieter Buys
Verlinden, Bianca K.
Reader, Janette
Joubert, Annie M.
Kaiser, Annette
Louw, Abraham Izak
Kirk, Kiaran
Phanstiel IV, Otto
Birkholtz, Lyn-Marie

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Microbiology

Abstract

Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in the nM-μM range. The compounds are taken up into the intraerythrocytic parasite where they arrest the parasite cell-cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.

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Keywords

Malaria, Plasmodium falciparum, Spermidine, Putrescine, Anthracene

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Citation

Niemand, J, Burger, P, Verlinden, BK, Reader, J, Joubert, AM, Kaiser, A, Louw, AI, Kirk, K, Phanstiel IV, O & Birkholtz, LM 2013, 'Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites', Antimicrobial Agents and Chemotherapy, vol. 57, no. 6, pp. 2874-2877.