Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites

dc.contributor.authorNiemand, Jandeli
dc.contributor.authorBurger, Pieter Buys
dc.contributor.authorVerlinden, Bianca K.
dc.contributor.authorReader, Janette
dc.contributor.authorJoubert, Annie M.
dc.contributor.authorKaiser, Annette
dc.contributor.authorLouw, Abraham Izak
dc.contributor.authorKirk, Kiaran
dc.contributor.authorPhanstiel IV, Otto
dc.contributor.authorBirkholtz, Lyn-Marie
dc.contributor.emaillynmarie.birkholtz@up.ac.zaen_US
dc.date.accessioned2013-10-02T07:04:24Z
dc.date.available2013-10-02T07:04:24Z
dc.date.issued2013-06
dc.description.abstractAnthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in the nM-μM range. The compounds are taken up into the intraerythrocytic parasite where they arrest the parasite cell-cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.en_US
dc.description.librarianhb2013en_US
dc.description.sponsorshipJN was supported by the Carl and Emily Fuchs foundation, AusAID, the Ernst and Ethel Eriksen Trust, UP Mentorship Programme and the Claude Leon Foundation. This work was supported by the South African Medical Research Council, the South African National Research Foundation KISC programme (UID 67444), and the Australian National Health and Medical Research Council [Grant no. 525428 to KK].en_US
dc.description.urihttp://aac.asm.orgen_US
dc.identifier.citationNiemand, J, Burger, P, Verlinden, BK, Reader, J, Joubert, AM, Kaiser, A, Louw, AI, Kirk, K, Phanstiel IV, O & Birkholtz, LM 2013, 'Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites', Antimicrobial Agents and Chemotherapy, vol. 57, no. 6, pp. 2874-2877.en_US
dc.identifier.issn0066-4804 (print)
dc.identifier.issn1098-6596 (online)
dc.identifier.other10.1128/AAC.00106-13
dc.identifier.urihttp://hdl.handle.net/2263/31871
dc.language.isoenen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.rights© 2013, American Society for Microbiology. All Rights Reserved.en_US
dc.subjectMalariaen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectSpermidineen_US
dc.subjectPutrescineen_US
dc.subjectAnthraceneen_US
dc.titleAnthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasitesen_US
dc.typePostprint Articleen_US

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