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Browsing Research Articles (Biochemistry) by UP Author "Louw, Abraham Izak"
Now showing items 1-20 of 21
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Niemand, Jandeli; Burger, Pieter Buys; Verlinden, Bianca K.; Reader, Janette; Joubert, Annie M.; Kaiser, Annette; Louw, Abraham Izak; Kirk, Kiaran; Phanstiel IV, Otto; Birkholtz, Lyn-Marie (American Society for Microbiology, 2013-06)Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in the nM-μM range. The compounds are taken up into the ...
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Moyo, Phanankosi; Kunyane, Phaladi; Selepe, Mamoalosi A.; Eloff, Jacobus Nicolaas; Niemand, Jandeli; Louw, Abraham Izak; Maharaj, Vinesh J.; Birkholtz, Lyn-Marie (BioMed Central, 2019-03-08)BACKGROUND : Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of different sources of drugs in search of ...
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Williams, Marni; Sprenger, Janina; Human, Esmare; Al-Karadaghic, Salem; Persson, Lo; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Elsevier B.V., 2011)Plasmodium falciparum like other organisms is dependent on polyamines for proliferation. Polyamine biosynthesis in these parasites is regulated by a unique bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase ...
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Williams, Marni; Louw, Abraham Izak; Birkholtz, Lyn-Marie (BioMed Central, 2007-05)BACKGROUND: The increasing emergence of Plasmodium falciparum parasites resistant to most of the cost-effective drugs has necessitated the identification of novel leads and drug targets. Parasitespecific inserts in enzymes ...
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Goble, Jessica L.; Johnson, Hailey; De Ridder, Jaco; Stephens, Linda L.; Louw, Abraham Izak; Blatch, Gregory L.; Boshoff, Aileen (Bentham Science Publisher, 2013)Plasmodium falciparum 1–deoxy–D–xylulose–5–phosphate reductoisomerase (PfDXR) is a key enzyme in the synthesis of isoprenoids in the malaria parasite, using a pathway that is absent in the human host. This enzyme is ...
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Birkholtz, Lyn-Marie; Van Brummelen, A.C. (Anna Catharina); Clark, Katherine; Niemand, Jandeli; Marechal, Eric; Llinas, M.; Louw, Abraham Izak (Elsevier, 2008-02)Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics ...
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Reeksting, S.B. (Shaun Bernard); Muller, Ingrid B.; Burger, Pieter Buys; Burgos, Emmanuel S.; Salmon, Laurent; Louw, Abraham Izak; Birkholtz, Lyn-Marie; Wrenger, Carsten (Portland Press on behalf of the Biochemical Society, 2013)Malaria tropica is a devastating infectious disease caused by Plasmodium falciparum. This parasite synthesizes vitamin B6 de novo via the pyridoxal 5-phosphate (PLP) synthase enzymatic complex consisting of PfPdx1 and ...
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Clark, Katherine; Niemand, Jandeli; Reeksting, S.B. (Shaun Bernard); Smit, Salome; Van Brummelen, A.C. (Anna Catharina); Williams, Marni; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Springer, 2010-02)Inhibition of polyamine biosynthesis and/or the perturbation of polyamine functionality have been exploited with success against parasitic diseases such as Trypanosoma infections. However, when the classical polyamine ...
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Birkholtz, Lyn-Marie; Blatch, Gregory; Coetzer, Theresa L.; Hoppe, Heinrich C.; Human, Esmare; Morris, Elizabeth J.; Ngcete, Zoleka; Oldfield, Lyndon; Roth, Robyn; Shonhai, Addmore; Stephens, Linda L.; Louw, Abraham Izak (BioMed Central, 2008)Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread resistance of Plasmodium parasites to the cost-effective chloroquine ...
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Birkholtz, Lyn-Marie; Bastien, Olivier; Wells, Gordon; Grando, Delphine; Joubert, Fourie; Kasam, Vinod; Zimmermann, Marc; Ortet, Philippe; Jacq, Nicolas; Saidani, Nadia; Roy, Sylvaine; Hofmann-Apitius, Martin; Breton, Vincent; Louw, Abraham Izak; Marechal, Eric (BioMed Central, 2006-11)The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term, by the necessity to ...
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Law, Philip J.; Claudel-Renard, Clotilde; Joubert, Fourie; Louw, Abraham Izak; Berger, David Kenneth (BioMed Central, 2008)BACKGROUND: Microarray technology makes it possible to identify changes in gene expression of an organism, under various conditions. Data mining is thus essential for deducing significant biological information such as the ...
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Moyo, Phanankosi; Mugumbate, Grace; Eloff, Jacobus Nicolaas; Louw, Abraham Izak; Maharaj, Vinesh J.; Birkholtz, Lyn-Marie (MDPI Publishing, 2020-09-17)The ability to block human-to-mosquito and mosquito-to-human transmission of Plasmodium parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a ...
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Burger, Pieter Buys; Williams, Marni; Sprenger, Janina; Reeksting, S.B. (Shaun Bernard); Botha, M.E. (Mariette); Muller, Ingrid B.; Joubert, Fourie; Birkholtz, Lyn-Marie; Louw, Abraham Izak (BioMed Central, 2015-02-05)BACKGROUND : Plasmodium falciparum is the most pathogenic of the human malaria parasite species and a major cause of death in Africa. It’s resistance to most of the current drugs accentuates the pressing need for ...
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Le Roux, Dina; Burger, Pieter Buys; Niemand, Jandeli; Grobler, Anne; Urbán, Patricia; Fernàndez-Busquets, Xavier; Barker, Robert H.; Serrano, Adelfa; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Elsevier, 2014-04)S-adenosyl-L-methionine decarboxylase (AdoMetDC) in the polyamine biosynthesis pathway has been identified as a suitable drug target in Plasmodium falciparum parasites, which causes the most lethal form of malaria. ...
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Becker, John V.W.; Mtwisha, Linda; Crampton, Bridget Genevieve; Stoychev, Stoyan H.; Van Brummelen, Anna Catharina; Reeksting, Shaun Bernard; Louw, Abraham Izak; Birkholtz, Lyn-Marie; Mancama, Dalu (BioMed Central, 2010-04)BACKGROUND: Plasmodium falciparum, the causative agent of severe human malaria, has evolved to become resistant to previously successful antimalarial chemotherapies, most notably chloroquine and the antifolates. The ...
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Birkholtz, Lyn-Marie; Williams, Marni; Niemand, Jandeli; Louw, Abraham Izak; Persson, Lo; Heby, Olle (Portland Press on behalf of the Biochemical Society, 2011-04-21)New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness, Chagas’ disease, leishmaniasis and malaria. Enzymes in polyamine biosynthesis and thiol ...
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Niemand, Jandeli; Louw, Abraham Izak; Birkholtz, Lyn-Marie; Kirk, K. (Elsevier, 2012-09)Polyamines and the enzymes involved in their biosynthesis are present at high levels in rapidly proliferating cells, including cancer cells and protozoan parasites. Inhibition of polyamine biosynthesis in asexual blood-stage ...
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Niemand, Jandeli; Birkholtz, Lyn-Marie; Louw, Abraham Izak; Kirk, K. (BioMed Central, 2010-10)Polyamines are present at high levels in proliferating cells, including cancerous cells and protozoan parasites and the inhibition of their synthesis has been exploited in antiproliferative strategies. Inhibition of the ...
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Smit, Salome; Stoychev, Stoyan H.; Louw, Abraham Izak; Birkholtz, Lyn-Marie (American Chemical Society, 2010-03)Two-dimensional gel electrophoresis (2-DE) is one of the most commonly used technologies to obtain a snapshot of the proteome at any specific time. However, its application to study the Plasmodial (malaria parasite) proteome ...
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Verlinden, Bianca K.; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Taylor and Francis, 2016-02)INTRODUCTION : Currently, widely used antimalarial drugs have a limited clinical lifespan due to parasite resistance development. With resistance continuously rising, antimalarial drug discovery requires strategies to ...
Now showing items 1-20 of 21