Medical Virology: Recent submissions

Now showing items 1-20 of 436

Advances in understanding bat infection dynamics across biological scales

Sanchez, Cecilia A.; Phelps, Kendra L.; Frank, Hannah K.; Geldenhuys, Marike; Griffiths, Megan E.; Jones, Devin N.; Kettenburg, Gwenddolen; Lunn, Tamika J.; Moreno, Kelsey R.; Mortlock, Marinda; Vicente-Santos, Amanda; Viquez-R, Luis R.; Kading, Rebekah C.; Markotter, Wanda; Reeder, DeeAnn M.; Olival, Kevin J. (Royal Society Publishing, 2024-03)

Over the past two decades, research on bat-associated microbes such as viruses, bacteria and fungi has dramatically increased. Here, we synthesize themes from a conference symposium focused on advances in the research of ...
Epidemiology and aetiology of moderate to severe diarrhoea in hospitalised patients ≥5 years old living with HIV in South Africa, 2018- 2021 : a case-control analysis

Johnstone, Siobhan; Erasmus, Linda; Thomas, Juno; Groome, Michelle J.; Du Plessis, Nicolette Marie; Avenant, Theunis Johannes; De Villiers, Maryke; Page, N.A. (Nicola) (Public Library of Science, 2023-09-08)

Diarrhoea is a recognised complication of HIV-infection, yet there are limited local aetiological data in this high-risk group. These data are important for informing public health interventions and updating diagnostic ...
Identification and molecular characterization of Shamonda virus in an aborted goat fetus in South Africa

Van der Walt, Miné; Rakaki, Matshepo E.; MacIntyre, Caitlin; Mendes, Adriano; Junglen, Sandra; Theron, Cherise; Anthony, Tasneem; O’Dell, Nicolize; Venter, Marietjie (MDPI, 2023-08)

Viruses in the Orthobunyavirus genus, Peribunyaviridae family, are associated with encephalitis, birth defects and fatalities in animals, and some are zoonotic. Molecular diagnostic investigations of animals with ...
Divergent Hantavirus in Somali shrews (Crocidura somalica) in the semi-arid North Rift, Kenya

Omoga, Dorcus C.A.; Tchouassi, David P.; Venter, Marietjie; Ogola, Edwin; Rotich, Gilbert; Muthoni, Joseph N.; Ondifu, Dickens O.; Torto, Baldwyn; Junglen, Sandra; Sang, Rosemary (MDPI, 2023-05-07)

Hantaviruses are zoonotic rodent-borne viruses that are known to infect humans and cause various symptoms of disease, including hemorrhagic fever with renal and cardiopulmonary syndromes. They have a segmented single-stranded, ...
Developing African arbovirus networks and capacity strengthening in arbovirus surveillance and response : findings from a virtual workshop

Braack, Leo; Wulandhari, Shobiechah A.; Chanda, Emmanuel; Fouque, Florence; Merle, Corinne S.; Nwangwu, Udoka; Velayudhan, Raman; Venter, Marietjie; Yahouedo, A. Gildas; Lines, Jo; Aung, Poe Poe; Chan, Kallista; Abeku, Tarakegn A.; Tibenderana, James; Clarke, Sian E. (BMC, 2023-04-14)

This meeting report presents the key findings and discussion points of a 3-h virtual workshop, held on 21 September 2022, and organized by the “Resilience Against Future Threats through Vector Control (RAFT)” research ...
Characterization of mosquito host-biting networks of potential Rift Valley fever virus vectors in north-eastern KwaZulu-Natal province, South Africa

Makhanthisa, Takalani Irene; Guarido, Milehna M.; Kemp, Alan; Weyer, Jacqueline; Rostal, Melinda K.; Karesh, William B.; Thompson, P.N. (Peter N.) (BMC, 2024-08)

BACKGROUND : Rift Valley fever virus (RVFV) is a zoonotic mosquito-borne virus with serious implications for livestock health, human health, and the economy in Africa, and is suspected to be endemic in north-eastern ...
Coding-complete genome of human alphaherpesvirus 1 isolated from a case of fulminant hepatitis

Viljoen, Natalie; Burt, Felicity; Weyer, Jacqueline (American Society for Microbiology, 2023-10)

We report the coding-complete genome sequence of human alphaherpesvirus 1 (HHV1) isolated from a previously healthy 64-year-old male with fulminant hepatitis, a rare presentation of a common viral agent. The sequence is ...
The values and risks of an intergovernmental Panel for One Health to strengthen pandemic prevention, preparedness, and response

Hobeika, Alexandre; Stauffer, Maxime Henri Tibault; Dub, Timothee; Van Bortel, Wim; Beniston, Martin; Bukachi, Salome; Burci, Gian Luca; Crump, Lisa; Markotter, Wanda; Sepe, Ludovico Pasquale; Placella, Enrichetta; Roche, Benjamin; Thiongane, Oumy; Wang, Zhanyun; Guerin, Frederique; Van Kleef, Esther (Elsevier, 2023-08)

The COVID-19 pandemic has shown the need for better global governance of pandemic prevention, preparedness, and response (PPR) and has emphasised the importance of organised knowledge production and uptake. In this ...
Reported antibiotic use among patients in the multicenter ANDEMIA infectious diseases surveillance study in sub-Saharan Africa

Wieters, Imke; Johnstone, Siobhan; Makiala-Mandanda, Sheila; Poda, Armel; Akoua-Koffi, Chantal; Abu Sin, Muna; Eckmanns, Tim; Galeone, Valentina; Kabore, Firmin; Kahwata, François; Leendertz, Fabian H.; Mputu, Benoit; Ouedraogo, Abdoul-Salam; Page, N.A.; Schink, Susanne B.; Toure, Fidele; Traoré, Adjaratou; Venter, Marietjie; Vietor, Ann Christin; Schubert, Grit; Tomczyk, Sara (BMC, 2024-01)

BACKGROUND: Exposure to antibiotics has been shown to be one of the drivers of antimicrobial resistance (AMR) and is critical to address when planning and implementing strategies for combatting AMR. However, data on ...
Now is the time to set up formal forums for clinical advice with emerging and zoonotic infections : a shared experience

Woolley, Stephen D.; Nel, Jeremy; Weyer, Jacqueline; Neary, Anne; Blumberg, Lucille Hellen; Beadsworth, Michael B.J. (Elsevier, 2024-07)

No abstract available.
Diversity of enteroviruses in cerebrospinal fluid specimens collected from hospitalised patients in the private and public sector in South Africa

Janse van Rensburg, Megan; Mans, Janet; Mafuyeka, Rendani T.; Strydom, Kathy-Anne; Myburgh, Marcelle; Van Zyl, Walda B. (Wiley, 2024-03)

Enteroviruses cause a wide range of neurological illnesses such as encephalitis, meningitis, and acute flaccid paralysis. Two types of enteroviruses, echovirus E4 and E9, have recently been detected in South Africa and are ...
Prevention of zoonotic spillover : from relying on response to reducing the risk at source

Markotter, Wanda; Mettenleiter, Thomas C.; Adisasmito, Wiku B.; Almuhairi, Salama; Behravesh, Casey Barton; Bilivogui, Pepe; Bukachi, Salome A.; Casas, Natalia; Becerra, Natalia Cediel; Charron, Dominique F.; Chaudhary, Abhishek; Zanella, Janice R. Ciacci; Cunningham, Andrew A.; Dar, Osman; Debnath, Nitish; Dungu, Baptiste; Farag, Elmoubasher; Gao, George F.; Hayman, David T.S.; Khaitsa, Margaret; Koopmans, Marion P.G.; Machalaba, Catherine; Mackenzie, John S.; Morand, Serge; Smolenskiy, Vyacheslav; Zhou, Lei (Public Library of Science, 2023-10-05)

BACKGROUND AND CONTEXT : The devastating impact of Coronavirus Disease 2019 (COVID-19) on human health globally has prompted extensive discussions on how to better prepare for and safeguard against the next pandemic. ...
Variations in small-scale movements of, Rousettus aegyptiacus, a Marburg virus reservoir across a seasonal gradient

Wood, Matthew Roger; De Vries, J.L.; Epstein, Jonathan H.; Markotter, Wanda (BMC, 2023-07-18)

BACKGROUND : Bats are increasingly being recognized as important hosts for viruses, some of which are zoonotic and carry the potential for spillover within human and livestock populations. Biosurveillance studies focused on ...
Southern Africa's great escarpment as an amphitheater of climate-driven diversification and a buffer against future climate change in bats

Taylor, Peter J.; Kearney, Teresa C.; Clark, Vincent Ralph; Howard, Alexandra; Mdluli, Monday V.; Markotter, Wanda; Geldenhuys, Marike; Richards, Leigh R.; Rakotoarivelo, Andrinajoro R.; Watson, Johan; Balona, Julio; Monadjem, Ara (Wiley, 2024-06)

Hosting 1460 plant and 126 vertebrate endemic species, the Great Escarpment (hereafter, Escarpment) forms a semi-circular “amphitheater” of mountains girdling southern Africa from arid west to temperate east. Since arid ...
A rabies-related lyssavirus from a Nycticeinops schlieffeni bat with neurological signs, South Africa

Viljoen, Natalie; Ismail, Arshad; Weyer, Jacqueline; Markotter, Wanda (American Society for Microbiology, 2023-11)

We report the coding-complete sequence of a lyssavirus, provisionally designated Phala bat lyssavirus (PBLV), characterized using a metagenomics approach. PBLV was identified in a Nycticeinops schlieffeni bat that exhibited ...
mAb therapy controls CNS-resident lyssavirus infection via a CD4 T cell-dependent mechanism

Mastraccio, Kate E.; Huaman, Celeste; Coggins, Si’Ana A.; Clouse, Caitlyn; Rader, Madeline; Yan, Lianying; Mandal, Pratyusha; Hussain, Imran; Ahmed, Anwar E.; Ho, Trung; Feasley, Austin; Vu, Bang K.; Smith, Ina L.; Markotter, Wanda; Weir, Dawn L; Laing, Eric D.; Broder, Christopher C; Schaefer, Brian C. (Springer, 2023-09-20)

Infections with rabies virus (RABV) and related lyssaviruses are uniformly fatal once virus accesses the central nervous system (CNS) and causes disease signs. Current immunotherapies are thus focused on the early, ...
Survey of West Nile and Banzi viruses in mosquitoes, South Africa, 2011–2018

MacIntyre, Caitlin; Guarido, Milehna M.; Riddin, Megan A.; Johnson, Todd; Braack, L.E.O.; Schrama, Maarten; Gorsich, Erin; Almeida, Antonio Paulo Gouveia; Venter, Marietjie (Centers for Disease Control and Prevention, 2023-01)

We collected >40,000 mosquitoes from 5 provinces in South Africa during 2011–2018 and screened for zoonotic flaviviruses. We detected West Nile virus in mosquitoes from conservation and periurban sites and potential new ...
Detection of neutralizing antibodies in COVID-19 patients from Steve Biko Academic Hospital Complex : a pilot study

Kgatle, Mankgopo; Chalwe, Joseph Musonda; Van der Westhuizen, Donald; Xu, Shuting; Damane, Botle Precious; Mathebela, Precious; Ueckermann, Veronica; Mayaphi, Simnikiwe; Rodrigues, Hosana Gomes; Moura-Alves, Pedro; Ndlovu, Honest; Mzizi, Yonwaba; Zongo, Lusanda; Hairwadzi, Henry; Vorster, Mariza; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-07-03)

A correlation between neutralization activity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and protection against coronavirus disease 2019 (COVID-19) has been demonstrated by several ...
The role of wastewater-based epidemiology for SARS-CoV-2 in developing countries : cumulative evidence from South Africa supports sentinel site surveillance to guide public health decision-making

Iwu-Jaja, Chinwe Juliana; Ndlovu, Nkosenhle Lindo; Rachida, Said; Yousif, Mukhlid; Taukobong, Setshaba; Macheke, Mokgaetji; Mhlanga, Laurette; Van Schalkwyk, Cari; Pulliam, Juliet R.C.; Moultrie, Tom; Le Roux, Wouter; Schaefer, Lisa; Pocock, Gina; Coetzee, Leanne Z.; Mans, Janet; Bux, Faizal; Pillay, Leanne; De Villiers, Dariah; Du Toit, A.P.; Jambo, Don; Gomba, Annancietar; Groenink, Shaun; Madgewick, Neil; Van der Walt, Martie; Mutshembele, Awelani; Berkowitz, Natascha; Suchard, Melinda S.; McCarthy, Kerrigan M. (Elsevier, 2023-12)

The uptake of wastewater-based epidemiology (WBE) for SARS-CoV-2 as a complementary tool for monitoring population-level epidemiological features of the COVID-19 pandemic in low-and-middle-income countries (LMICs) is low. ...
Validation of ASCL1 and LHX8 methylation analysis as primary cervical cancer screening strategy in South African women with human immunodeficiency virus

Vink, Frederique J.; Meijer, Chris J.L.M.; Lissenberg-Witte, Birgit I.; Visser, Cathy; Duin, Sylvia; Snyman, Leon Cornelius; Richter, Karin Louise; Van der Merwe, Frederick H.; Botha, Matthys H.; Steenbergen, Renske D.M.; Dreyer, Greta (Oxford University Press, 2023-02-01)

BACKGROUND : Compared with women who are human immunodeficiency virus (HIV) negative, women with human immunodeficiency virus (WWH) have a higher human papillomavirus (HPV) prevalence and increased cervical cancer ...

Now showing items 1-20 of 436

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