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Browsing Health Sciences by UP Author "Tintinger, Gregory Ronald"
Now showing items 1-20 of 41
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Nel, Jan Gert; Tintinger, Gregory Ronald (MDPI Publishing, 2020-12)This study probed the di erential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 50-diphosphate (ADP, 100 mol L1) ...
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Joseph, Darren; Tintinger, Gregory Ronald; Ker, James A.; Pannell, N. (South African Medical Association NPC, 2021)The therapy of autoimmune rheumatological conditions has undergone significant changes with the introduction of biologic antiinflammatory agents including cytokine antagonists and agents that interfere with the function ...
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Repsold, Lisa; Pool, Roger; Karodia, Mohammed; Tintinger, Gregory Ronald; Becker, Piet J.; Joubert, Anna Margaretha (Wiley, 2021-06)Chronic myeloid leukaemia (CML) is a malignancy of the haematopoietic stem cells. The first line of treatment for CML, especially in developing countries, remains the first-generation tyrosine kinase inhibitor, Imatinib. ...
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Anderson, Ronald; Tintinger, Gregory Ronald; Cockeran, Riana; Potjo, Moliehi; Feldman, Charles (Molecular Diversity Preservation International, 2010-05)In general antibiotics interact cooperatively with host defences, weakening and decreasing the virulence of microbial pathogens, thereby increasing vulnerability to phagocytosis and eradication by the intrinsic antimicrobial ...
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Durandt, Chrisna; Tintinger, Gregory Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014-03)The clinical relevance of the anti-inflammatory properties of beta-2 agonists remains contentious possibly due to differences in their molecular structures and agonist activities. The current study has compared the effects ...
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Cockeran, Riana; Mutepe, Ndiafhi Daphney; Theron, Annette J.; Tintinger, Gregory Ronald; Steel, Helen C.; Stivaktas, Paraskevi Irene; Richards, Guy A.; Feldman, Charles; Anderson, Ronald (Oxford University Press, 2012)OBJECTIVES: Tigecycline is the prototype of the recently introduced, intravenously administered glycylcycline class of antibiotics, developed in response to the increasing problem of antibiotic resistance in Gram-positi ...
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Cigarette smoke condensate attenuates phorbol ester-mediated neutrophil extracellular trap formation Bokaba, Refilwe Philadelphia; Anderson, Ronald; Theron, Annette J.; Tintinger, Gregory Ronald (Makerere University Medical School, 2017-09)BACKGROUND : Neutrophil extracellular traps (NETs) constitute a network of chromatin fibres containing histone and antimicrobial peptides that are released by activated neutrophils. NETs protect the host against infection ...
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Ally, Mahmood Moosa Tar Mahomed; Hodkinson, Bridget; Meyer, Pieter Willem Adriaan; Musenge, Eustasius; Tintinger, Gregory Ronald; Tikly, Mohammed; Anderson, Ronald (BioMed Central, 2015-05-29)BACKGROUND : To measure circulating anti-citrullinated peptide antibodies (ACPA) and cytokines pre- and 6 months post-therapy as a strategy to predict and optimize responses to traditional disease-modifying antirheumatic ...
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Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
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Hendricks, Candice Laverne; Herd, Candice Lee; Nel, Marcel; Tintinger, Gregory Ronald; Pepper, Michael Sean (Frontiers Media, 2021-02-19)The pandemic caused by SARS-CoV-2 has infected more than 94 million people worldwide (as of 17 January 2020). Severe disease is believed to be secondary to the cytokine release syndrome (CRS or “cytokine storm”) which ...
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Theron, Annette J.; Steel, Helen C.; Tintinger, Gregory Ronald; Gravett, Cornelia M.; Anderson, Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014)Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, ...
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Mayaphi, Simnikiwe Horatious; Brauer, Marieke; Morobadi, Daniel M.; Mazanderani, Ahmad Haeri; Mafuyeka, Rendani T.; Olorunju, Steve A.S.; Tintinger, Gregory Ronald; Stoltz, Anton Carel (Public Library of Science, 2014-04-03)BACKGROUND : Cytomegalovirus (CMV) infection is associated with severe diseases in immunosuppressed patients; however, there is a lack of data for pre-emptive therapy in patients with HIV/AIDS. METHOD : This was a ...
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Abdullah, Fareed; Myers, J.; Basu, Debashis; Tintinger, Gregory; Ueckermann, Veronica; Mathebula, M.; Ramlall, R.; Spoor, S.; De Villiers, T.; Van der Walt, Z.; Cloete, Jeane; Soma-Pillay, Priya; Rheeder, Paul; Paruk, Fathima; Engelbrecht, Adel; Lalloo, Vidya; Myburg, M.; Kistan, J.; Van Hougenhouck-Tulleken, W.G. (Wesley); Boswell, Michael T.; Gray, G.; Welch, R.; Blumberg, Lucille Hellen; Jassat, W. (Elsevier, 2022-03)INTRODUCTION : The coronavirus disease 2019 (COVID-19) first reported in Wuhan, China in December 2019 is a global pandemic that is threatening the health and wellbeing of people worldwide. To date there have been more ...
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Mayaphi, Simnikiwe Horatious; Martin, Desmond J.; Quinn, Thomas C.; Laeyendecker, Oliver; Olorunju, Steve A.S.; Tintinger, Gregory Ronald; Stoltz, Anton Carel (Public Library of Science, 2016-10-20)BACKGROUND: Two thirds of the world's new HIV infections are in sub-Saharan Africa. Acute HIV infection (AHI) is the time of virus acquisition until the appearance of HIV antibodies. Early HIV infection, which includes ...
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Madzime, Morris; Theron, Annette J.; Anderson, Ronald; Tintinger, Gregory; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Nel, Jan Gert; Feldman, Charles; Rossouw, Theresa M. (Taylor and Francis, 2022)Please read abstract in the article.
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Richards, Guy A.; Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (MDPI Publishing, 2018-05-14)Dabigatran is an oral direct thrombin inhibitor, and rivaroxaban, a factor Xa inhibitor. Dabigatran has been implicated in the etiology of acute coronary syndromes and as these occur following inflammatory changes in the ...
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Theron, Annette J.; Feldman, Charles; Richards, Guy A.; Tintinger, Gregory Ronald; Anderson, Ronald (AME Publishing Company, 2019-12)Although the usage of electronic (e)-cigarettes (EC) and similar devices has gained in popularity as an apparent smoking cessation strategy, serious concerns are emerging in relation to both the efficacy of this strategy, ...
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Kwofie, Luyanda Laura Illicia; Rapoport, Bernardo Leon; Fickl, Heidi; Meyer, Pieter Willem Adriaan; Rheeder, Paul; Hlope, H.; Anderson, Ronald; Tintinger, Gregory Ronald (Springer, 2012-04)The soluble Triggering Receptor Expressed on Myeloid cells 1 (sTREM-1) is a useful marker of infection in patients with sepsis, but has not been adequately evaluated in patients with chemotherapy-associated febrile ...
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Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (2012-04-16)In trace amounts, some heavy metals are essential for optimum health, while exposure to others, which are non-essential, presents the potential hazard of acute or chronic organ toxicity. Cadmium, mercury, lead, ...
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Anderson, Ronald; Tintinger, Gregory Ronald; Feldman, Charles (AOSIS Open Journals, 2014-01)Chronic inflammation of both infective and non-infective origin has been implicated in the aetiology of approximately 30% of all human epithelial malignancies. The primary carcinogens are reactive oxygen species (ROS) ...
Now showing items 1-20 of 41