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Browsing Health Sciences by UP Author "Theron, Anne Elisabeth"
Now showing items 1-9 of 9
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Janse van Vuuren, Rustelle; Visagie, M.H. (Michelle Helen); Theron, Anne Elisabeth; Joubert, Annie M. (SpringerOpen, 2015-12)Cancer is a complex disease since it is adaptive in such a way that it can promote proliferation and invasion by means of an overactive cell cycle and in turn cellular division which is targeted by antimitotic drugs that ...
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Verwey, M.; Nolte, Elsie Magdalena; Joubert, Annie M.; Theron, Anne Elisabeth (BioMed Central, 2016-12-08)BACKGROUND : Autophagy can either be protective and confer survival to stressed cells, or it can contribute to cell death. The antimitotic drug 2-ethyl-3-O-sulpamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) is an in ...
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Theron, Andre P.; Brisighelli, Giulia; Theron, Anne Elisabeth; Leva, Ernesto; Numanoglu, Alp (Springer, 2015-08)PURPOSE : Aim of study was to evaluate the differences in incidence and presentation of anorectal malformations (ARMs) between selected Pediatric Surgery Divisions in the Republic of South Africa (ZAR) and Italy. METHODS ...
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Nel, Marcel; Joubert, Anna Margaretha; Dohle, Wolfgang; Potter, Barry V.L.; Theron, Anne Elisabeth (Dove Medical Press, 2018)BACKGROUND : A and B rings of the steroidal microtubule disruptor, 2-methoxyestradiol, and its analogs can be mimicked with a tetrahydroisoquinoline (THIQ) core. THIQs are cytotoxic agents with potential anticancer activities. ...
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Theron, Anne Elisabeth; Nolte, Elsie M.; Lafanechere, Laurence; Joubert, Annie M. (BioMed Central, 2013-08-27)BACKGROUND: 2-Methoxyestradiol has been shown to induce both autophagy and apoptosis in various carcinogenic cell lines. Although a promising anti-cancer agent, it has poor bioavailability and rapid in vivo metabolism ...
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Theron, Anne Elisabeth; Visagie, M.H. (Michelle Helen); Mqoco, T.V. (Thandi Vuyelwa); Stander, Andre; Prudent, Renaud; Lafanechere, Laurence; Joubert, Annie M. (Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)Using a novel synthesised sulphamoylated 2-methoxyestradiol analogue, C19, two types of cell death, namely apoptosis and autophagy, were demonstrated in vitro when cervical cancer HeLa cells were exposed to this compound.
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Theron, Anne Elisabeth; Prudent, Renaud; Nolte, Elsie M.; Van den Bout, Jan Iman; Punchoo, Rivak; Marais, Sumari; Du Toit, Peet J.; Hlophe, Yvette Nkondo; Van Papendorp, D.H. (Dirk Hermanus), 1949-; Lafanechere, Laurence; Joubert, Annie M. (Springer, 2015-02)PURPOSE : 2-Methoxyestradiol (2ME) is a promising anticancer agent that disrupts the integrity and dynamics of the spindle network. In order to overcome the pharmacokinetic constraints of this compound, a panel of ...
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Hendricks, Rushdi; Davids, Malika; Khalfey, Hoosain; Landman, Hilda J; Theron, Anne Elisabeth; Engela, Eugene; Dheda, Keertan (Medknow Publications, 2019)The gold standard of treatment for obstructive sleep apnea (OSA) is continuous positive airway pressure (CPAP). However, more than a third of patients have such difficulty with its chronic use such that they seek other ...
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Visagie, M.H. (Michelle Helen); Theron, Anne Elisabeth; Mqoco, T.V. (Thandi Vuyelwa); Vieira, Warren Antonio; Prudent, Renaud; Martinez, Anne; Lafanechere, Laurence; Joubert, Annie M. (Public Library of Science, 2013-09-05)2-Methoxyestradiol (2ME2) is a naturally occurring estradiol metabolite which possesses antiproliferative, antiangiogenic and antitumor properties. However, due to its limited biological accessibility, synthetic analogues ...
Now showing items 1-9 of 9