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Browsing Health Sciences by UP Author "Porchet, Hervé"
Now showing items 1-6 of 6
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Porchet, Hervé; Vidal, Virginie; Kornmann, Gabrielle; Malpass, Sam; Curtin, Francois (Elsevier, 2019-09)PURPOSE : Temelimab/GNbAC1 is a humanized immunoglobulin G4 monoclonal antibody antagonist of the human endogenous retrovirus W envelope protein, which is associated with multiple sclerosis (MS) pathophysiology and possibly ...
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Curtin, Francois; Bernard, Corinne; Levet, Sandrine; Perron, Hervé; Porchet, Hervé; Medina, Julie; Malpass, Sam; Lloyd, David; Simpson, Richard (Wiley, 2018-09)We describe a newly identified therapeutic target for type 1 diabetes (T1D): an envelope protein of endogenous retroviral origin, human endogenous retrovirus W envelope (HERV‐W‐Env). HERV‐W‐Env was found to be detected in ...
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Derfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; Rasenack, Maria; Matthey, Alain; Du Pasquier, Renaud; Schluep, Myriam; Desmeules, Jules; Lang, Alois B.; Perron, Hervé; Faucard, Raphael; Porchet, Hervé; Hartung, Hans-Peter; Kappos, Ludwig; Lalive, Patrice H. (Sage, 2015-06)BACKGROUND : GNbAC1 is an immunoglobulin (IgG4) humanised monoclonal antibody against multiple sclerosis-associated retrovirus (MSRV)-Env, a protein of endogenous retroviral origin, expressed in multiple sclerosis (MS) ...
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Derfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; Rasenack, Maria; Matthey, Alain; Du Pasquier, Renaud; Schluep, Myriam; Desmeules, Jules; Lang, Alois B.; Perron, Hervé; Faucard, Raphael; Porchet, Hervé; Hartung, Hans-Peter; Kappos, Ludwig; Lalive, Patrice H. (Elsevier, 2015-08)GNbAC1 is a humanized monoclonal antibody targeting MSRV-Env, an endogenous retroviral protein, which is expressed inmultiple sclerosis (MS) lesions, is pro-inflammatory and inhibits oligodendrocyte precursor cell ...
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Curtin, François; Perron, Hervé; Kromminga, Arno; Porchet, Hervé; Lang, Alois B. (Taylor and Francis, 2015-01)Monoclonal antibodies (mAbs) play an increasing important role in the therapeutic armamentarium against multiple sclerosis (MS), an inflammatory and degenerative disorder of the central nervous system. Most of the mAbs ...
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Curtin, F.; Bernard, C.; Porchet, Hervé; Levet, S.; Medina, J.; Perron, H.; Oates, S.; Lloyd, D.; Simpson, R. (Wiley, 2018)AIMS : Human endogenous retroviruses (HERVs) elements, remnants of ancestral viral genomic insertions, are emerging targets in several autoimmune diseases. In type 1 diabetes (T1D) patients, the envelope protein of HERV-W ...
Now showing items 1-6 of 6