Browsing Health Sciences by Type "Postprint Article"

Browsing Health Sciences by Type "Postprint Article"

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  • 1,4,7-Triazacyclononane restores the activity of β-lactam antibiotics against metallo-β-lactamase-producing Enterobacteriaceae : exploration of potential metallo-β-lactamase inhibitors 
    Somboro, Anou M.; Amoako, Daniel G.; Osei Sekyere, John; Kumalo, Hezekiel M.; Khan, René; Bester, Linda A.; Essack, Sabiha Y. (American Society for Microbiology, 2019-02)
    Metallo-β-lactamase (MBL)-producing Enterobacteriaceae are of grave clinical concern, particularly as there are no metallo-β-lactamase inhibitors approved for clinical use. The discovery and development of MBL inhibitors ...
  • The 1/4/6x24 campaign to cure tuberculosis quickly 
    McKenna, Lindsay; Frick, Mike; Angami, Ketholelie; Dubula, Vuyiseka; Furin, Jennifer; Harrington, Mark; Hausler, Harry; Heitkamp, Petra; Herrera, Rosa; Lynch, Sharonann; Mitnick, Carole D.; Moses, Gloriah Kerubo; Ndjeka, Norbert; Nyang'wa, Bern-Thomas; Palazuelos, Lindsay; Ulysse, Patrick; Pai, Madhukar (Springer, 2023-01)
    The “right of everyone to enjoy the benefits of scientific progress and its applications,” also known as the right to science, is enshrined in the Universal Declaration of Human Rights and international human rights law. ...
  • A 10-year audit of burns at Kalafong Hospital 
    Eyal, A.S.; Kemp, M.; Luvhengo, T. (Elsevier, 2007-05)
    Kalafong Hospital is a secondary hospital situated to the west of Pretoria. It serves as the regional burns centre for Gauteng province north of the Jukskei river. It mainly serves a poor population. This is a retrospective ...
  • A 10-year audit of pregnancies affected by diabetic ketoacidosis at the Pretoria Academic Complex 
    Maseko, Ncamsile F.; Van Zyl, Danie G.; Adam, Sumaiya (Wiley, 2022-09)
    BACKGROUND : Diabetic ketoacidosis (DKA) during pregnancy is associated with increased rates of maternal and perinatal mortality and morbidity. DKA management guidelines are designed to ensure optimal management and minimize ...
  • 17-beta-estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines 
    Visagie, M.H. (Michelle Helen); Birkholtz, Lyn-Marie; Joubert, Annie M. (Wiley, 2014)
    Microtubules are important targets when studying potential anticancer agents since disturbance of these microtubule dynamics results in cell cycle arrest and cell death. 2-Methoxyestradiol is a naturally occurring metabolite ...
  • 18F-FDG PET/CT as a noninvasive biomarker for assessing adequacy of treatment and predicting relapse in patients treated for pulmonary tuberculosis 
    Lawal, Ismaheel Opeyemi; Fourie, Bernard P.; Mathebula, Matsontso; Moagi, Ingrid; Lengana, Thabo; Moeketsi, Nontando; Nchabeleng, Maphoshane; Hatherill, Mark; Sathekge, Mike Machaba (Society of Nuclear Medicine, 2020-03)
    Microbial culture is the gold standard for determining the effectiveness of tuberculosis treatment. End-of-treatment (EOT) 18F-FDG PET/CT findings are variable among patients with negative microbial culture results after ...
  • 18F-FDG-PET/CT imaging of uterine cervical cancer recurrence in women with and without HIV infection 
    Lawal, Ismaheel Opeyemi; Ololade, Kehinde; Popoola, Gbenga O.; Ankrah, Alfred O.; Vorster, Mariza; Maes, Alex; Mokgoro, N.P. (Neo); Van de Wiele, Christophe; Sathekge, Mike Machaba (Edizioni Minerva Medica, 2022-03)
    BACKGROUND : To compare the rate, time and, pattern of recurrence of cervical cancer between patients with and without HIV infection and to determine factors predicting cervical cancer recurrence in patients evaluated by ...
  • 2-Methoxyestradiol-bis-sulfamate induces apoptosis and autophagy in a tumorigenic breast epithelial cell line 
    Visagie, M.H. (Michelle Helen); Joubert, Annie M. (Springer, 2011-11)
    In anticancer research where the focus is on finding agents that induces cell death while leaving nontumorigenic cells less affected, a novel 2-methoxyestradiol derivative has come forth. 2-Methoxyestradiol-bis-sulfam ...
  • 2023 updated MASCC/ESMO consensus recommendations: controlling nausea and vomiting with chemotherapy of low or minimal emetic potential 
    Olver, Ian; Clark-Snow, Rebecca; Ruhlmann, Christina H.; Garcia-del-Barrio, Maria-Angeles; Schwartzberg, Lee; Rapoport, Bernardo Leon; Jahn, Franziska (Springer, 2024-01)
    PURPOSE : Review the literature to update the MASCC guidelines from 2016 for controlling nausea and vomiting with systemic cancer treatment of low and minimal emetic potential. METHODS : A working group performed a ...
  • 3-Methylglutaconic aciduria-lessons from 50 genes and 977 patients 
    Wortmann, Saskia B.; Kluijtmans, Leo A. J.; Rodenburg, Richard J.; Sass, Jörn Oliver; Nouws, Jessica; Van Kaauwen, Edwin P.; Kleefstra, Tjitske; Tranebjaerg, Lisbeth; De Vries, Maaike C.; Isohanni, Pirjo; Walter, Katharina; Alkuraya, Fowzan S.; Smuts, Izelle; Reinecke, Carolus J.; Van der Westhuizen, Francois Hendrikus; Thorburn, David; Smeitink, Jan A.M.; Morava, Eva; Wevers, Ron A. (Springer, 2013-11)
    Elevated urinary excretion of 3-methylglutaconic acid is considered rare in patients suspected of a metabolic disorder. In 3-methylglutaconyl-CoA hydratase deficiency (mutations in AUH), it derives from leucine degradation. ...
  • [68 Ga]Ga-FAPI versus [18F]F-FDG in malignant melanoma: complementary or counterpoint? 
    Mokoala, Kgomotso M.G.; Emil, Novruzov; Lawal, Ismaheel Opeyemi; Antke, Christina; Giesel, Frederik L.; Sathekge, Mike Machaba (Springer, 2022-06)
    No abstract available.
  • [68Ga]Ga-NODAGAZOL uptake in atherosclerotic plaques correlates with the cardiovascular risk profile of patients 
    Ndlovu, Honest; Lawal, Ismaheel Opeyemi; Popoola, Gbenga O.; Brits, Bradley; Mokoala, Kgomotso M.G.; Maserumule, Letjie; Hlongwa, K.; Mahapane, Johncy; Davis, Cindy; Sathekge, Mike Machaba (Springer, 2022-07)
    Please read abstract in the article.
  • Aberrant function of the C-terminal tail of HIST1H1E accelerates cellular senescence and causes premature aging 
    Flex, Elisabetta; Martinelli, Simone; Van Dijck, Anke; Ciolfi, Andrea; Cecchetti, Serena; Coluzzi, Elisa; Pannone, Luca; Andreoli, Cristina; Radio, Francesca Clementina; Pizzi, Simone; Carpentieri, Giovanna; Bruselles, Allessandro; Catanzaro, Giuseppina; Pedace, Lucia; Miele, Evelina; Carcarino, Elena; Ge, Xiaoyan; Chijiwa, Chieko; Lewis, M.E. Suzanne; Meuwissen, Marije; Kenis, Sandra; Van der Aa, Nathalie; Larson, Austin; Brown, Kathleen; Wasserstein, Melissa P.; Skotko, Brian G.; Begtrup, Amber; Person, Richard; Karayiorgou, Maria; Roos, J.L. (Johannes Louw); Van Gassen, Koen L.; Koopmans, Marije; Bijlsma, Emilia K.; Santen, Gijs W.E.; Barge-Schaapveld, Daniela Q.C.M.; Ruivenkamp, Claudia A.L.; Hoffer, Mariette J.V.; Lalani, Seema R.; Streff, Haley; Craigen, William J.; Graham, Brett H.; Van den Elzen, Annette P.M.; Kamphuis, Daan J.; Ounap, Katrin; Reinson, Karit; Pajusalu, Sander; Wojcik, Monica H.; Viberti, Clara; Di Gaetano, Cornelia; Bertini, Enrico; Petrucci, Simona; De Luca, Alessandro; Rota, Rossella; Ferretti, Elisabetta; Matullo, Giuseppe; Dallapiccola, Bruno; Sgura, Antonella; Walkiewicz, Magdalena; Kooy, R. Frank; Tartaglia, Marco (Elsevier, 2019-09)
    Histones mediate dynamic packaging of nuclear DNA in chromatin, a process that is precisely controlled to guarantee efficient compaction of the genome and proper chromosomal segregation during cell division and to accomplish ...
  • Aberrant synthesis of ATP synthase resulting from a novel deletion in mitochondrial DNA in an African patient with progressive external ophthalmoplegia 
    Van der Westhuizen, Francois Hendrikus; Smet, Joel; Levanets, Oksana; Meissner-Roloff, Madelein; Louw, Roan; Van Coster, Rudy; Smuts, Izelle (Springer, 2010-01)
    A young, adult, African male patient presented with progressive proximal muscle weakness, external ophthalmoplegia and ptosis, as well as cardiac conduction abnormalities resembling Kearns–Sayre syndrome (KSS). Magnetic ...
  • Aberrant vascular anatomy associated with artifactual focal avidity in the liver on PSMA PET 
    Lawal, Ismaheel Opeyemi; Pectasides, Melina; Parihar, Ashwin Singh; Shah, Hardik U.; Halkar, Raghuveer K.; Jani, Ashesh B.; Schuster, David M. (Lippincott Williams and Wilkins, 2023-09)
    68Ga–prostate-specific membrane antigen (PSMA) PET/CT is a valuable tool for staging and restaging of prostate cancer. Prostate-specific membrane antigen expression is not specific to prostate cancer, as it is expressed ...
  • The ability of three African herbal remedies to offer protection against an in vitro model of Parkinson’s disease 
    Lepule, Keagile Hilda; Cordier, Werner; Steenkamp, Paul; Nell, Margo Judith; Steenkamp, Vanessa (Elsevier, 2019-11)
    Parkinson’s disease, characterised by loss of dopaminergic neurons in the substantia nigra of the brain, is attributed to oxidative stress and mitochondrial dysfunction. As no cure is available, and dopamine-replacement ...
  • Acceptance and insight : incapacity to give informed consent 
    Van Staden, C.W. (Werdie) (Wolters Kluwer Lippincott Williams & Wilkins, 2009-11)
    PURPOSE OF REVIEW: To highlight areas for potential refinement in assessments of capacity to give informed consent. RECENT FINDINGS: The clinical assessment of the patient's capacity to give informed consent may be informed ...
  • Accuracy and reliability of measurements obtained from computed tomography 3D volume rendered images 
    Stull, Kyra Elizabeth; Tise, Meredith L.; Ali, Zabiullah; Fowler, David R. (Elsevier, 2014-05)
    Forensic pathologists commonly use computed tomography (CT) images to assist in determining the cause and manner of death as well as for mass disaster operations. Even though the design of the CT machine does not inherently ...
  • Accuracy of bone SPECT/CT for identifying hardware loosening in patients who underwent lumbar fusion with pedicle screws 
    Hudyana, Hendrah; Maes, Alex; Vandenberghe, Thierry; Fidlers, Luc; Sathekge, Mike Machaba; Nicolai, Daniel; Van de Wiele, Christophe (Springer, 2016-02)
    BACKGROUND : The aim of this retrospective study was to evaluate the accuracy of bone SPECT (single photon emission computed tomography)/CT (computed tomography) in diagnosing loosening of fixation material in patients ...
  • The accuracy of topographical and shape analysis using three-dimensional surface scanning compared to micro-computed tomography 
    Ridel, A.F. (Alison); Bothma, Nomshado Pearl; Liebenberg, Leandi; Oettle, Anna Catherina; L'Abbe, Ericka Noelle (Elsevier, 2023-09)
    The high number of unidentified bodies recorded in South Africa annually, combined with substantial heterogeneity within the population, necessitates that innovative forensic analysis methods be developed that incorporate ...