Browsing Health Sciences by Subject "G protein-coupled receptor (GPCR)"

Browsing Health Sciences by Subject "G protein-coupled receptor (GPCR)"

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  • Pharmacoperones for misfolded gonadotropin receptors 
    Newton, Claire L.; Anderson, Ross Calley (Springer, 2018)
    The gonadotropin receptors (luteinising hormone receptor; LHR and follicle-stimulating hormone receptor; FSHR) are G protein-coupled receptors (GPCRs) that play an important role in the endocrine control of reproduction. ...
  • Rescue of cell surface expression and signaling of mutant follicle-stimulating hormone receptors 
    Hanyroup, Sharika; Anderson, Ross Calley; Nataraja, Selvaraj; Yu, Henry N.; Millar, Robert P.; Newton, Claire L. (Oxford University Press, 2021-12)
    Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many cause receptor misfolding and failure to reach the cell surface. Pharmacological chaperones are cell-permeant small molecules that engage ...