Abstract:
INTRODUCTION: Antimicrobial resistance (AMR) constitutes a significant threat to global health and food
security, typically associated with high morbidity and mortality rate. The high burden of infectious diseases coupled with the weak health systems in most countries of Africa magnifies
the risk of increasing AMR and its consequences thereof. This scoping review will be aimed
at mapping the evidence on interventions used to prevent and manage antimicrobial resistance in Africa, guided by the “One Health” concept.
METHODS: We will consider interventions targeting multiple sectors such as health care systems, the
agricultural and veterinary sectors. The outcomes to be considered include reduction of
AMR decreased morbidity and mortality due to infectious diseases, increased awareness
for rational use of antimicrobials and reduced antibiotic consumption. We will include all
types of studies regardless of study designs conducted within the context of the WHO African region. Studies will be excluded if they are not conducted in Africa and if they are literature reviews, only describing the concept of AMR without mentioning interventions.
We will include studies identified through a comprehensive search of peer-reviewed and
grey literature databases. In addition, we will search the reference lists of included studies
and relevant reviews. Finally, we plan to do a citation search for included studies. Findings of this review will be narratively synthesized.
