dc.contributor.author |
Mosana, Mmahiine
|
|
dc.contributor.author |
Ayeleso, Ademola
|
|
dc.contributor.author |
Nyakudya, Trevor Tapiwa
|
|
dc.contributor.author |
Erlwanger, Kennedy
|
|
dc.contributor.author |
Mukwevho, Emmanuel
|
|
dc.date.accessioned |
2021-07-05T09:50:01Z |
|
dc.date.available |
2021-07-05T09:50:01Z |
|
dc.date.issued |
2020 |
|
dc.description.abstract |
The effect of neonatal oral supplementation of oleanolic acid (OA) on peroxisome proliferator-activated
receptor gamma
(PPARγ)-1 on glucose homeostasis in high fructose-fed
rats was investigated. Rat pups (7 days old) were randomly assigned to and
randomly administered with control (Distilled water, DW), OA (60 mg/kg), metformin (MET, 500 mg/kg), high fructose solution
(HFS, 20% w/v), OA + HFS, MET + HFS, and treated till postnatal day (PND) 14. The pups were weaned onto a standard diet
on PND 21 up to PND 111 and terminated on PND 112. Glucose derivatives and gene expressions of PPARγ-1 and glucose
transporter type 4 (Glut-4) in the skeletal muscles were determined by using reverse transcription-quantitative
polymerase chain
reaction and gas chromatography-mass
spectrometry, respectively. HFS significantly lowered glucose concentration and showed
the propensity to suppress the expression of PPARγ-1, but not significantly. OA and MET alone significantly increased PPARγ-1
and Glut-4 expressions. There was no significant difference between the OA and OA + HFS for PPARγ-1 and Glut-4 expressions,
although OA expressions were always higher than that of the OA + HFS group. An elevated level of glucose-6-phosphate
was
observed in OA, MET, and OA + HFS groups. Ribose-5-phosphate
was significantly higher in OA and MET groups than the
control. Ribose-5-phosphate
was also significantly high in OA-treated
group compared with OA + HFS. It is concluded that the
neonatal supplementation with OA could help to improve the activity of PPARγ in reducing the burden of metabolic diseases. |
en_ZA |
dc.description.department |
Physiology |
en_ZA |
dc.description.librarian |
am2021 |
en_ZA |
dc.description.sponsorship |
The National Research Foundation of South Africa, University of the Witwatersrand, University of Johannesburg and the North West University, South Africa. |
en_ZA |
dc.description.uri |
https://journals.sagepub.com/home/npx |
en_ZA |
dc.identifier.citation |
Mosana, M., Ayeleso, A., Nyakudya, T. et al. 2020, 'Potential protective effects of neonatal supplementation with oleanolic acid on peroxisome proliferator-activated receptor gamma (PPARγ)-ligand dependent regulation of glucose homeostasis in high fructose-fed rats', Natural Product Communications, vol. 15, no. 3, pp. 1-7. |
en_ZA |
dc.identifier.issn |
1934-578X (print) |
|
dc.identifier.issn |
1555-9475 (online) |
|
dc.identifier.other |
10.1177/1934578X20913747 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/80722 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Natural Product |
en_ZA |
dc.rights |
© The Author(s) 2020.
Creative Commons Non Commercial CC BY-NC:
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial
4.0 License. |
en_ZA |
dc.subject |
Obesity |
en_ZA |
dc.subject |
Oleanolic acid |
en_ZA |
dc.subject |
High fructose |
en_ZA |
dc.subject |
Metabolic diseases |
en_ZA |
dc.subject |
Neonatal oral supplementation |
en_ZA |
dc.subject |
Peroxisome proliferator-activated receptor gamma (PPARγ)-1 |
en_ZA |
dc.title |
Potential protective effects of neonatal supplementation with oleanolic acid on peroxisome proliferator-activated receptor gamma (PPARγ)-ligand dependent regulation of glucose homeostasis in high fructose-fed rats |
en_ZA |
dc.type |
Article |
en_ZA |