Immune-mediated inflammatory disorders include a clinically diverse group of conditions sharing similar pathogenic mechanisms.
Conditions such as rheumatoid arthritis, psoriasis, spondyloarthropathy, inflammatory bowel disease and connective tissue
diseases are characterised by immune dysregulation and chronic inflammation. This review will focus immuno-pathogenic
mechanisms, aspects of early disease, co-morbidity and therapy in rheumatoid arthritis.